Abstract
Giriş ve Amaç: Folik asit eksikliği, homozigot beta-talasemi hastalarında bilinen bir durumdur. Etkili olmayan eritropoezis nedeni ile sürekli transfüzyon yapılan beta-talasemi hastaları daha fazla folik aside ihtiyaç duyarlar. Buna karşın, talasemi hastalarında vitamin B12 eksikliği daha nadir görülmektedir. Talasemi majorde görülen mikrositoz, folik asit ve vitamin B12 eksikliğinin hematolojik bulgularını maskeleyebilir. Bu çalışmada beta-talasemi majör hastalarında vitamin B12 ve folik asit seviyelerini araştırmayı amaçladık. Yöntem: Talasemi major tanısı ile izlediğimiz 92 hastanın vitamin B12 ve folik asit düzeyi ölçüldü. Hiçbir hastaya son 1 yıl içinde vitamin B12 ve/veya folik asit verilmemişti. Sonuçlar: Talasemi major hastalarında vitamin B12, folik asit, vitamin B12 ve folik asit eksikliği birlikteliği sırası ile %13, %9.8, %2.2 oranında saptanmıştır. Sonuç: Ortalama eritrosit hacmi (MCV), talasemi major hastalarında vitamin B12 ve folik asit eksikliğini göstermede iyi bir parametre olmadığı düşünülmektedir.Talasemi major hastalarında vitamin B12 ve folik asit seviyelerinin belirli aralıklar ile ölçülmesini önermekteyiz.
Keywords
References
- Claster S, Wood JC, Noetzli L, Carson SM, Hofstra TC, Khanna R, Coates TD. Nutritional deficiencies in iron overloaded patients with hemoglobi- nopathies.Am J Hematol 2009;84:344-348.
- Tavil B, Sipahi T. Masked deficit of vitamin B12 in a Turkish girl with thalassemia. Pediatr Hematol Oncol. 2004;21:363-365.
- Mazzone A, Vezzoli M, Ottini E. Masked deficit of B 12 and folic acid in thalassemia Am J Hematol, 2001;67: 274.
Abstract
Objective: Homozygous beta thalassemia patients are known to have folic acid deficiency. Undertransfused patients with beta-thalassemia major may need more folic acid as they continue to have ineffective erytropoesis. In contrast, vitamin B12 deficiency is rare in patients with beta-thalassemia major. In thalassemic patients, microcytosis may mask the hematological finding of macrocytosis seen in folic acid and Vitamin B12 deficiecy. In this study, we investigated the levels of vitamin B12 and folic acid in patients with beta thalassemia major.Method: Plasma vitamin B12 and folic acid levels were determined in 92 thalassemia major patients. None had received folic acid and/or vitamin B12 supplementation in the last year.Results: We found that 13%, 9.8%, and 2.2% of thalassemic patients have in vitamin B12, folic acid, and both vitamin B12 and folic acid deficiency, respectively.Conclusion: Mean corpuscular volume (MCV) is not a good marker of folic acid ve vitamin B12 deficiency in talasemia major patients. We recommend that vitamin B12 and folic acid levels of thalassemia major patients should be measured periodically
Keywords
References
- Claster S, Wood JC, Noetzli L, Carson SM, Hofstra TC, Khanna R, Coates TD. Nutritional deficiencies in iron overloaded patients with hemoglobi- nopathies.Am J Hematol 2009;84:344-348.
- Tavil B, Sipahi T. Masked deficit of vitamin B12 in a Turkish girl with thalassemia. Pediatr Hematol Oncol. 2004;21:363-365.
- Mazzone A, Vezzoli M, Ottini E. Masked deficit of B 12 and folic acid in thalassemia Am J Hematol, 2001;67: 274.
Details
| Other ID | JA94HY39CT |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2010 |
| Submission Date | December 1, 2010 |
| Published in Issue | Year 2010 Volume: 4 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
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