Abstract
Graves hastalığında radyoaktif iyot tedavisi (RIT) oldukça etkin, ucuz, kolay uygulanabilen ve güvenilir bir yöntem olmakla birlikte, çocukluk çağındaki kullanımı yaygın değildir. Bu çalışmada antitiroid ilaç tedavisine yanıt vermeyen 7 Graves olgusunda uygulanan RIT sunulacaktır. Çalışmaya 11-14 yaş arasında, 6' sı kız biri erkek 7 Graves olgusu alındı. Tüm olgulara ilk seçenek olarak antitiroid ilaç tedavisi (propiltiourasil 3-6 mg/kg/gün) başlandı. Yaklaşık 2-6 yıl tedavisi sürdürülen 6 olguda iyileşme olmaması, bir hastada ise ilaca bağlı hepatotoksisite gelişmesi nedeni ile RIT 10-15 mCi dozunda uygulandı. Tüm olgularda 3 ay içinde remisyon sağlanırken bir yıllık izlemlerinde relaps veya RIT' e bağlı herhangi bir komplikasyon görülmedi. Bu çalışma ile antitiroid ilaç tedavisine yanıt alınamayan veya ciddi yan etkisi görülen Graves hastalığında, çocuk ve adolesanlarda da RIT' nin etkin bir tedavi olduğu sonucuna varıldı.
Keywords
References
- Moll GW, Patel BR. Pediatric Graves' disease therapeutic options and experience with radioiodine at the University of Mississippi Medical Center; South Med Jo 1997; 90: 1017-1022.
- Rivkees SA, Sklar C, Freemark M. Clinical review gg: The management of Graves' disease in children, with special emphasis on radioiodine treatment. J Clin Endocrinol Metab 1998; 83: 3767-3776.
- efficacy and safety of radioactive iodine in treating young graves' patients. J Clin Endocrinol Metab 2004;89: 4229-4233.
- LaFranchi S, Mandel SH. Graves' disease in the neonatal period and childhood. In:Braverman LE, Utiger RD, editors. Werner and Ingbar's the thyroid. 7th ed. Philadelphia:Lippincott-Raven 1996, p1000-1008. 12.Bonnema SJ, Nielsen VE, Hegedus L. Long-term effects of radioiodine on thyroid function, size and patient satisfaction in non- toxic diffuse goitre. Eur J Endocrinol 2004;150: 439-445.
Abstract
Radioiodine therapy (RIT) is a safe and effective treatment option for management of childhood-onset Graves' disease. The aim of this study was to evaluate the efficacy of RIT in 7 childhood-onset Graves' patients who had relapsed following the initial medical therapy. The patients consisted of 6 females and 1 male whose ages ranged from 11 to 14 years. All patients received propylthiouracil (3-6 mg/kg/day) as the initial antithyroid drug therapy. During 2-6 years follow-up, 6 patients did not show remission and the remaining one patient developed toxic hepatitis due to the antithyroid drugs. RIT (10-15 mCi) were given following antithyroid drug therapy. Remission was achieved in all patients within 3 months. No complication related to RIT was observed during 1 year follow-up. Our data demonstrated that RIT is an effective and safe therapy for childhood-onset Graves' patients who has relapsed disease after initial medical therapy
Keywords
References
- Moll GW, Patel BR. Pediatric Graves' disease therapeutic options and experience with radioiodine at the University of Mississippi Medical Center; South Med Jo 1997; 90: 1017-1022.
- Rivkees SA, Sklar C, Freemark M. Clinical review gg: The management of Graves' disease in children, with special emphasis on radioiodine treatment. J Clin Endocrinol Metab 1998; 83: 3767-3776.
- efficacy and safety of radioactive iodine in treating young graves' patients. J Clin Endocrinol Metab 2004;89: 4229-4233.
- LaFranchi S, Mandel SH. Graves' disease in the neonatal period and childhood. In:Braverman LE, Utiger RD, editors. Werner and Ingbar's the thyroid. 7th ed. Philadelphia:Lippincott-Raven 1996, p1000-1008. 12.Bonnema SJ, Nielsen VE, Hegedus L. Long-term effects of radioiodine on thyroid function, size and patient satisfaction in non- toxic diffuse goitre. Eur J Endocrinol 2004;150: 439-445.
Details
| Other ID | JA49EY47SJ |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2007 |
| Submission Date | June 1, 2007 |
| Published in Issue | Year 2007 Volume: 1 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
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