Tip 1 Diyabetes Mellituslu Hastalarda 25- Hidroksi Vitamin D Düzeyi ve Metabolik Kontrol Arasındaki İlişki
Abstract
Amaç: Diyabetes Mellitus, insülin sekresyonu, insülin etkisi veya her ikisindeki bozukluğa bağlı olarak gelişen kan şekeri
yüksekliği ile karakterize metabolik bozukluktur. Diyabet ilişkili komplikasyonlardan korunmak için metabolik kontrol takibi
glikolize hemoglobin A1C ile yapılmaktadır. 25-hidroksi vitamin D steroid yapıda bir hormon olup pankreasta insülin
salgılanmasında etkili olduğu bilinmektedir. Bu çalışma Tip 1 diyabetli çocuklarda D vitamini eksikliği sıklığının ve metabolik
kontrol ile ilişkisini araştırmak amacıyla yapılmıştır.
Gereç ve Yöntemler: Bu retrospektif çalışmada, tip 1 diyabetli 109 çocuk değerlendirildi. Serum 25-hidroksivitamin
D, hemoglobin A1C, tiroid fonksiyon testleri, kalsiyum, fosfor, magnezyum, parathormon ve alkalen fosfataz düzeyleri
ölçüldü. Hastalar vitamin D düzeyine göre eksik, yetersiz veya normal olarak 3 gruba ayrıldı.
Bulgular: Serum 25(OH)D düzeyleri, hastaların%31.8’inde eksik veya yetersiz saptandı. 25(OH)D düzeyi< 20 ng / mL
olan hasta grubunda parathormon ve alkalen fosfataz düzeyleri 25(OH)D düzeyi≥ 20 ng / mL olan gruba göre yüksek (p
<0.05) bulundu. Vitamin D düzeyi ile metabolik kontrol arasında anlamlı ilişki bulunamadı.
Sonuç: Sonuç olarak, Vitamin D eksikliği ile metabolik parametreler arasında anlamlı bir ilişki bulamamış olsak da, tip
1 diyabet gibi kronik bir hastalığı olanlarda 25(OH)D ve metabolitlerinin metabolik kontrol ile ilişkisi olsun ya da olmasın
sistemik etkileri göz önüne alınarak rutin bakılması gerektiğini düşünmekteyiz.
Keywords
References
- 1. American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes care 2003;26:5-20.
- 2. Kerner W, Brückel J. Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes 2014;122:384-6.
- 3. Satman İ. Diabetes Mellitus tanı ve izleminde yeni kriterler ve belirlenme gerekçeleri. Türkiye Klinikleri J Int Med Sci 2007;3:1-15.
- 4. Rewers M, Pihoker C, Donaghue K, Hanas R, Swift P, Kllingensmith GJ. Assessment and monitoring of glycemic control in children and adolescents with diabetes. Pediatr Diabetes 2007;8:408-18.
- 5. Adamczak DM, Nowak JK, Frydrychowicz M, Kaczmarek M, Sikora J. The role of toll‐like receptors and vitamin D in diabetes mellitus type 1–A review. Scand J Immunol 2014;80:75-84.
- 6. Collins ED, Norman AW. Vitamin D. In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ (eds). Handbook of Vitamins. 3rd ed. New York: Markel Dekker, 2001:51-114.
- 7. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia 2008;51:1391-8.
- 8. Mutlu A, Mutlu GY, Ozsu E, Cizmecioglu FM, Hatun S. Vitamin D deficiency in children and adolescents with type 1 diabetes. J Clin Res Pediatr Endocrinol 2011;3:179-83.
- 9. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48:1247-57.
- 10. Tunc O, Cetinkaya S, Kizilgun M, Aycan Z. Evaluation of the relation between vitamin D and insulin requirements and frequency of osteopenia/osteoporosis in childhood with type 1 diabetes. 49th Annual Meeting of the ESPE; 2010, Sep 22-25;Prague,Czech Republic.
- 11. Svoren BM, Volkening LK, Wood JR, Laffel LM. Significant vitamin D deficiency in youth with T1D mellitus. J Pediatr 2009;154:132-4.
- 12. Hamed EA, Faddan NH, Elhafeez HA, Sayed D. Parathormone– 25(OH)-vitamin D axis and bone status in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 2011;12:536–46.
- 13. Huynh T, Greer R, Nyunt O, Bowling F, Cowley D, Leong GM, et al. The association between ketoacidosis and 25(OH)-vitamin D3 levels at presentation in children with type 1 diabetes mellitus. Pediatr Diabetes 2009;10:38–43.
- 14. Carnevale V, Romagnoli E, D’Erasmo E. Skeletal involvement in patients with diabetes mellitus. Diabetes Metab Res Rev 2004;20:196–204.
Abstract
References
- 1. American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes care 2003;26:5-20.
- 2. Kerner W, Brückel J. Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes 2014;122:384-6.
- 3. Satman İ. Diabetes Mellitus tanı ve izleminde yeni kriterler ve belirlenme gerekçeleri. Türkiye Klinikleri J Int Med Sci 2007;3:1-15.
- 4. Rewers M, Pihoker C, Donaghue K, Hanas R, Swift P, Kllingensmith GJ. Assessment and monitoring of glycemic control in children and adolescents with diabetes. Pediatr Diabetes 2007;8:408-18.
- 5. Adamczak DM, Nowak JK, Frydrychowicz M, Kaczmarek M, Sikora J. The role of toll‐like receptors and vitamin D in diabetes mellitus type 1–A review. Scand J Immunol 2014;80:75-84.
- 6. Collins ED, Norman AW. Vitamin D. In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ (eds). Handbook of Vitamins. 3rd ed. New York: Markel Dekker, 2001:51-114.
- 7. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia 2008;51:1391-8.
- 8. Mutlu A, Mutlu GY, Ozsu E, Cizmecioglu FM, Hatun S. Vitamin D deficiency in children and adolescents with type 1 diabetes. J Clin Res Pediatr Endocrinol 2011;3:179-83.
- 9. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48:1247-57.
- 10. Tunc O, Cetinkaya S, Kizilgun M, Aycan Z. Evaluation of the relation between vitamin D and insulin requirements and frequency of osteopenia/osteoporosis in childhood with type 1 diabetes. 49th Annual Meeting of the ESPE; 2010, Sep 22-25;Prague,Czech Republic.
- 11. Svoren BM, Volkening LK, Wood JR, Laffel LM. Significant vitamin D deficiency in youth with T1D mellitus. J Pediatr 2009;154:132-4.
- 12. Hamed EA, Faddan NH, Elhafeez HA, Sayed D. Parathormone– 25(OH)-vitamin D axis and bone status in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 2011;12:536–46.
- 13. Huynh T, Greer R, Nyunt O, Bowling F, Cowley D, Leong GM, et al. The association between ketoacidosis and 25(OH)-vitamin D3 levels at presentation in children with type 1 diabetes mellitus. Pediatr Diabetes 2009;10:38–43.
- 14. Carnevale V, Romagnoli E, D’Erasmo E. Skeletal involvement in patients with diabetes mellitus. Diabetes Metab Res Rev 2004;20:196–204.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | ORIGINAL ARTICLES |
| Authors | |
| Publication Date | December 30, 2018 |
| Submission Date | September 26, 2017 |
| Published in Issue | Year 2018 Volume: 12 Issue: 4 |
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