Abstract
Valproik asit, epilepsi, duygudurum bozuklukları, migren profilaksisi gibi hastalıklarda yaygın olarak kullanılan bir ilaçtır. Terapötik aralığının dar olması ve kullanım endikasyonlarının genişliği sebebiyle valproik asit zehirlenmeleriyle sıkça karşılaşılmaktadır. Burada valproik asit zehirlenmesi olan ve hemodiyaliz ile tedavi edilen bir olgu bildirilmiştir. Bilinen hiçbir hastalığı olmayan 14 yaşındaki kız hasta intihar amaçlı valproik asit alma sebebiyle çocuk yoğun bakım birimine kabul edildi. Hastanın ilaç alımından üç saat sonra başvurusunda yapılan tetkiklerinde serum valproik asit seviyesi 347.8 μg/mL olarak saptandı. Kan gazında yüksek anyon açıklı metabolik asidoz ve laktat yüksekliği dikkati çekti. Metabolik asidozun kötü prognoza işaret etmesine istinaden, hastaya organ yetmezliği bulguları gelişmeden hemodiyaliz uygulandı. Dört saatlik hemodiyaliz sonrası hastanın uykuya meyili ortadan kayboldu, serum valproik asit seviyesi azalarak normal referans aralıklarına geldi. Hastanın metabolik asidozu düzeldi, laktat yüksekliği ortadan kalktı. Tedavi sonrası bulguları düzelen hasta salah ile taburcu edildi. Yüksek doz valproik asit zehirlenmesi olgularında hemodiyaliz tedavisi başarılı olabilir. Bu olguda yüksek doz valproik asit zehirlenmesi olan hastalarda organ yetmezliği bulguları gelişmeden yapılan hemodiyalizin etkili olabileceği gösterilmiştir.
Keywords
References
- 1. Sztajnkrycer MD. Valproic acid toxicity: Overview and management. J Toxicol Clin Toxicol 2002;40:789-801.
- 2. Al Aly Z, Yalamanchili P, Gonzalez E. Extracorporeal management of valproic acid toxicity: A case report and review of the literature. Semin Dial 2005;18:62-6.
- 3. Doyon S. Anticonvulsants. In: Goldfrank LR, Howland MA, Flomenbaum NE (eds). Goldfrank’s Toxicologic Emergencies. 9th ed. New York, NY: McGraw Hill, 2011:47-705,706.
- 4. Sikma MA, Mier JC, Meulenbelt J. Massive valproic acid overdose, a misleading case. Am J Emerg Med 2008;26:110.e3-6
Abstract
References
- 1. Sztajnkrycer MD. Valproic acid toxicity: Overview and management. J Toxicol Clin Toxicol 2002;40:789-801.
- 2. Al Aly Z, Yalamanchili P, Gonzalez E. Extracorporeal management of valproic acid toxicity: A case report and review of the literature. Semin Dial 2005;18:62-6.
- 3. Doyon S. Anticonvulsants. In: Goldfrank LR, Howland MA, Flomenbaum NE (eds). Goldfrank’s Toxicologic Emergencies. 9th ed. New York, NY: McGraw Hill, 2011:47-705,706.
- 4. Sikma MA, Mier JC, Meulenbelt J. Massive valproic acid overdose, a misleading case. Am J Emerg Med 2008;26:110.e3-6
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | CASE REPORTS |
| Authors | |
| Publication Date | July 30, 2019 |
| Submission Date | November 13, 2018 |
| Published in Issue | Year 2019 Volume: 13 Issue: 4 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.