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Year 2020, Volume: 14 Issue: 1, 2 - 6, 27.01.2020

Yaşar Topal , Hasan Delıktaş , Hatice Topal Mehmet Çetınkaya Can Naci Kocabaş

https://doi.org/10.12956/tchd.578335

Abstract

References

  • 1. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 1999;34(5):646–56.
  • 2. Darling R, Roughton F. The effect of methemoglobin on the equilibrium between oxygen and hemoglobin. Am J Physiol 1942; 137:56.
  • 3. Kane GC, Hoehn SM, Behrenbeck TR, Mulvagh SL. Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors. Arch Intern Med 2007; 167: 1977-82.
  • 4. Vasters FG, Eberhart LH, Koch T, P. Kranke, H. Wulf , A. M. Morin. Risk factors for prilocaine-induced methaemoglobinaemia following peripheral regional anaesthesia. Eur J Anaesthesiol 2006;23:760–5.
  • 5. Trapp L, Will J. Acquired Methemoglobinemia Revisited. Dent Clin N Am 2010; 54(4) :665–675
  • 6. Hegesh E, Hegesh J, Kaftory A. Congenital methemoglobinemia with a deficiency of cytochrome b5. N Engl J Med 1986; 314(12):757-61.
  • 7. Coleman MD, Coleman NA. Drug-induced methaemoglobinaemia. Treatment issues. Drug 
Saf 1996; 14(6):394-405
  • 8. Kreshak AA, Ly BT, Edwards WC, Carson SH. A 3-year-old boy with fever and oral lesions. Diagnosis: methemoglobinemia. Pediatr Ann 2009; 38: 613-16.
  • 9. Khan NA, Kruse JA. Methemoglobinemia induced by topical anesthesia: a case report and review. Am J Med Sci 1999; 318: 415-18.
  • 10. Goldfrank L, Flomenbaum N, Lewin N, Weisman R. Goldfrank’s Toxicologic Emergencies. 6th ed. Stamford, CT: Appleton & Lange; 1998 Mansouri A, Lurie AA. Concise review: methemoglobinemia. Am J Hematol 1993; 42: 7-12.
  • 11. Bronstein AC, Spyker DA, Cantilena LR, Rumack BH, Dart RC. 2011 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila) 2012; 50(10): 911-1164.
  • 12. Guay J. Methemoglobinemia related to local anesthetics: a summary of 242 episodes. Anesth Analg. 2009;108(3):837-45.
  • 13. Vallurupalli S, Manchanda S. Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures. Local Reg Anesth. 2011;4:25-8.
  • 14. Nishimura K. Methemoglobinemia due to local anesthetics. Osaka City Med J 1971;17:25–42.
  • 15. Ash-Bernal R, Wise R, Wright SM. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore). 2004;83(5):265-73
  • 16. Amr El-Husseini MD Nick Azarov MD. Is threshold for treatment of methemoglobinemia the same for all? A case report and literature review. American Journal of Emergency Medicine 2010; 28(6): 748.e5–748.
  • 17. Hall NM1, Jones FJ, Ainsworth CR, Fincher RK Methemoglobinemia in patients undergoing esophagogastroduodenoscopy: a randomized controlled trial. Mil Med. 2013;178(6):701-4.
  • 18. Aksu TA, Esen F, Dolunay S, Alıcıgüzel Y, Yücel G, Çalı Ş. Erytrocyte glucose-6-phosphate dehydrogenase deficiency in Antalya Province, Turkey: an epidemiologic and biochemical study. Am J Epidemiol 1990;131(6):1094-7
  • 19. Kinoshita A, Nakayama Y, Kitayama T, Tomita M. Simulation study of methemoglobin reduction in erythrocytes. Differential contributions of two pathways to tolerance to oxidative stress. FEBS J.2007;274(6):1449–1458.
  • 20. Law RM, Halpern S, Martins RF, Reich H, Innanen V, Ohlsson A. Measurement of methemoglobin after EMLA analgesia for newborn circumcision. Biol Neonate 1996; 70: 213-17.
  • 21. Taddio A, Ohlsson A, Einarson Tr, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics 1998; 101:E1
  • 22. Lehr J, Masters A, Pollack B. Benzocaine-induced methemoglobinemia in the pediatric population. 2012 ;27(5):583-8.
  • 23. Rechetzki KF, Henneberg R, da Silva PH, do Nascimento AJ. Reference values for methemoglobin concentrations in children. Rev Bras Hematol Hemoter. 2012. 34(1):14-6
  • 24. Hsieh H-S, Jaffe E. The metabolism of methemoglobin in human erythrocytes. In: Stugenor D, ed. The red blood cell. New York: Academic Press; 1975.

Investigation of methemoglobinemia incidence among children undergoing circumcision using prilocaine.

Year 2020, Volume: 14 Issue: 1, 2 - 6, 27.01.2020

Yaşar Topal , Hasan Delıktaş , Hatice Topal Mehmet Çetınkaya Can Naci Kocabaş

https://doi.org/10.12956/tchd.578335

Abstract

Introduction:Methemoglobinemia is a clinical entity characterized by substitution of ferrous iron (Fe++) in the hemoglobin structure by ferric iron that lacks oxygen carrying capacity. Acquired methemoglobinemia may occur due to oxidant substances and drugs, of which local anesthetics constitute an important group. In this study the incidence of prilocaine-induced methemoglobinemia was studied.

 

Materials and Method:This study was performed on children who presented to the urology department for circumcision. Methemoglobin levels were measured prior to and after prilocaine injection.

 

Results:The study enrolled 74 children aged 6 months to 12 years. Of the cases, 19.7% were found to have methemoglobinemia but none had symptoms. Mean preoperative and postoperative incidences of methemoglobinemia were 0.71% and 1.80%, respectively. Methemoglobin level was reduced as age of the patient increased.

 

Conclusion:The risk of methemoglobinemia should be considered with local anesthetic agents widely used in clinical practice, particularly in small age groups.


Giriş:Methemoglobinemi, hemoglobindeki  ferröz demirin (Fe++) yerini oksijen taşıma kapasitesi olmayan ferrik demirin (Fe+3) alması ile karakterize bir klinik durumdur. Edinsel methemoglobinemi, oksidan maddeler ve ilaçlara bağlı olarak ortaya çıkabilirken, lokal anestezikler ilaçlar arasında önemli bir grubu oluşturur. Bu çalışmada prilokaine bağlı methemoglobinemi sıklığı araştırılmıştır. 

Materyal Metod:Çalışma 2013 yılında üroloji polikliniğine sünnet amacıyla başvuran çocuklar arasında yapıldı. Prilokain öncesi ve sonrası methemoglobin düzeyleri araştırıldı. 

Bulgular:Çalışmaya yaşları 6 ay ile 12 yaş arasında değişen 74 çocuk dahil edildi. Olguların %19.7’sinde methemoglobinemi saptanırken semptomatik olan olgu saptanmadı. Methemoglobinemi ortalaması preoperatif %0.71, postoperatif  %1.80 olarak saptandı. Yaşın artışına parelel olarak methemoglobin düzeyinin azaldığı gözlendi.

Sonuçlar:Günlük pratikte sıklıkla kullanılan lokal anesteziklerin kullanımı ile özellikle küçük yaş grubunda methemoglobinemi riski göz önünde bulundurulmalıdır.

Keywords

Prilocaine methemoglobinemia circumcised children Prilokain methemoglobinemi

References

  • 1. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 1999;34(5):646–56.
  • 2. Darling R, Roughton F. The effect of methemoglobin on the equilibrium between oxygen and hemoglobin. Am J Physiol 1942; 137:56.
  • 3. Kane GC, Hoehn SM, Behrenbeck TR, Mulvagh SL. Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors. Arch Intern Med 2007; 167: 1977-82.
  • 4. Vasters FG, Eberhart LH, Koch T, P. Kranke, H. Wulf , A. M. Morin. Risk factors for prilocaine-induced methaemoglobinaemia following peripheral regional anaesthesia. Eur J Anaesthesiol 2006;23:760–5.
  • 5. Trapp L, Will J. Acquired Methemoglobinemia Revisited. Dent Clin N Am 2010; 54(4) :665–675
  • 6. Hegesh E, Hegesh J, Kaftory A. Congenital methemoglobinemia with a deficiency of cytochrome b5. N Engl J Med 1986; 314(12):757-61.
  • 7. Coleman MD, Coleman NA. Drug-induced methaemoglobinaemia. Treatment issues. Drug 
Saf 1996; 14(6):394-405
  • 8. Kreshak AA, Ly BT, Edwards WC, Carson SH. A 3-year-old boy with fever and oral lesions. Diagnosis: methemoglobinemia. Pediatr Ann 2009; 38: 613-16.
  • 9. Khan NA, Kruse JA. Methemoglobinemia induced by topical anesthesia: a case report and review. Am J Med Sci 1999; 318: 415-18.
  • 10. Goldfrank L, Flomenbaum N, Lewin N, Weisman R. Goldfrank’s Toxicologic Emergencies. 6th ed. Stamford, CT: Appleton & Lange; 1998 Mansouri A, Lurie AA. Concise review: methemoglobinemia. Am J Hematol 1993; 42: 7-12.
  • 11. Bronstein AC, Spyker DA, Cantilena LR, Rumack BH, Dart RC. 2011 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila) 2012; 50(10): 911-1164.
  • 12. Guay J. Methemoglobinemia related to local anesthetics: a summary of 242 episodes. Anesth Analg. 2009;108(3):837-45.
  • 13. Vallurupalli S, Manchanda S. Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures. Local Reg Anesth. 2011;4:25-8.
  • 14. Nishimura K. Methemoglobinemia due to local anesthetics. Osaka City Med J 1971;17:25–42.
  • 15. Ash-Bernal R, Wise R, Wright SM. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore). 2004;83(5):265-73
  • 16. Amr El-Husseini MD Nick Azarov MD. Is threshold for treatment of methemoglobinemia the same for all? A case report and literature review. American Journal of Emergency Medicine 2010; 28(6): 748.e5–748.
  • 17. Hall NM1, Jones FJ, Ainsworth CR, Fincher RK Methemoglobinemia in patients undergoing esophagogastroduodenoscopy: a randomized controlled trial. Mil Med. 2013;178(6):701-4.
  • 18. Aksu TA, Esen F, Dolunay S, Alıcıgüzel Y, Yücel G, Çalı Ş. Erytrocyte glucose-6-phosphate dehydrogenase deficiency in Antalya Province, Turkey: an epidemiologic and biochemical study. Am J Epidemiol 1990;131(6):1094-7
  • 19. Kinoshita A, Nakayama Y, Kitayama T, Tomita M. Simulation study of methemoglobin reduction in erythrocytes. Differential contributions of two pathways to tolerance to oxidative stress. FEBS J.2007;274(6):1449–1458.
  • 20. Law RM, Halpern S, Martins RF, Reich H, Innanen V, Ohlsson A. Measurement of methemoglobin after EMLA analgesia for newborn circumcision. Biol Neonate 1996; 70: 213-17.
  • 21. Taddio A, Ohlsson A, Einarson Tr, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics 1998; 101:E1
  • 22. Lehr J, Masters A, Pollack B. Benzocaine-induced methemoglobinemia in the pediatric population. 2012 ;27(5):583-8.
  • 23. Rechetzki KF, Henneberg R, da Silva PH, do Nascimento AJ. Reference values for methemoglobin concentrations in children. Rev Bras Hematol Hemoter. 2012. 34(1):14-6
  • 24. Hsieh H-S, Jaffe E. The metabolism of methemoglobin in human erythrocytes. In: Stugenor D, ed. The red blood cell. New York: Academic Press; 1975.
There are 24 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section ORIGINAL ARTICLES
Authors

Yaşar Topal 0000-0002-7059-4823

Hasan Delıktaş 0000-0002-0973-2318

Hatice Topal This is me 0000-0003-3226-0205

Mehmet Çetınkaya This is me 0000-0001-8395-646X

Can Naci Kocabaş 0000-0001-8859-7187

Publication Date January 27, 2020
Submission Date July 2, 2019
Published in Issue Year 2020 Volume: 14 Issue: 1

Cite

Vancouver Topal Y, Delıktaş H, Topal H, Çetınkaya M, Kocabaş CN. Investigation of methemoglobinemia incidence among children undergoing circumcision using prilocaine. Türkiye Çocuk Hast Derg. 2020;14(1):2-6.


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