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Lösemili Çocuklarda SARS COV-2 Enfeksiyonu

Year 2020, COVID-19, 41 - 47, 24.07.2020
https://doi.org/10.12956/tchd.743711

Abstract

Şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2) tüm dünyada dikkatle ve kaygıyla izlenmektedir. Epidemiyolojik modeller, mevcut COVID-19 pandemisinin bir aşı ve / veya sürü bağışıklığı gelişene kadar birkaç ay hatta birkaç yıl süreceğini tahmin etmektedir. Çocuklarda COVID-19 enfeksiyonu genellikle hafif seyretmekle birlikte, özellikle bağışıklığı zayıflamış lösemili çocuklarda hayatı tehdit edebilir. Hematopoetik ve lenfoid kanserler tüm çocukluk çağı kanserlerinin yaklaşık % 40'ını oluşturmaktadır. Çocukluk çağı kanserlerinde ülkemizde beş yıllık sağkalım oranı % 70'e ve lösemi için bu oran % 80'e ulaşmıştır. COVID-19 salgını sırasında, lösemili çocuklarda, özellikle kemoterapi nedeniyle kemik iliğinin baskılandığı dönemde, COVID-19 enfeksiyonuna yakalanma riski yüksek olabilir. Altta yatan kanser türü, kanserin remisyon durumu veya kök hücre nakli yapılmış olması gibi faktörler de enfeksiyona cevabı etkileyebilir. Nötropenik ateşli hastalarda, standart ve kanıtlanmış tedavilerin yanı sıra, COVID 19 için şüpheli hastalarda olduğu gibi tüm testler ve tedaviler çok hızlı ve uygun bir şekilde uygulanmalıdır. Bu çabalar kanserli çocuklarımızın hayatta kalma oranını arttırmaya katkıda bulunacaktır. Kemoterapisi devam eden hastalarda SARS-CoV-2 enfeksiyonu ile ilgili verilerin yeterli olmaması nedeniyle, lösemili çocuklar gibi sistemik immünsüpresif tedavileri devam etmesi gereken hastalarda, immünosüpresif tedavinin azaltılması veya ertelenmesi gibi sorulara cevap aranmaktadır.
COVID-19'un dünya çapında hızla yayılması, hastalıktan korunmak için gerekli stratejilerin ve etkin tıbbi tedavilerin geliştirilmesiniı gerektirmektedir. Bu yazıda pandemi döneminde lösemili çocuklarda gelişebilecek COVID-19'un önlenmesi, tanı koyulması ve enfeksiyon geliştiğinde tedavi protokollerine yönelik literature dayalı uygun yaklaşımları derlemeye çalıştık.

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SARS COV-2 Infection in Children with Leukemia

Year 2020, COVID-19, 41 - 47, 24.07.2020
https://doi.org/10.12956/tchd.743711

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directed great attention and anxiety all over the world. Epidemiologic models predict that the current COVID-19 pandemic will last several months or even several years, until the development of a vaccine and/or herd immunity. Although the course of the infection is often not severe in children, it can be life threatening especially in immunocompromised children with leukemia. Hematopoietic and lymphoid cancers are accounting for approximately 40% of all childhood cancers. The five-year survival rate for childhood cancer has approached to 70% and more than 80% for leukemia in our country. During COVID pandemic, children with leukemia may also have COVID-19 infection, especially when their bone marrow is depressed due to chemotherapy. It is observed that factors such as the underlying type of cancer, status of remission, or having stem cell transplantation may affect the prognosis. As well as standard and proven treatments for febrile neutropenia, all tests and treatments should be applied very quickly and properly for COVID 19 as is all suspected patients. These efforts may contribute to increase the survival of our children with cancer. Given the absence of data to address concerns related to SARS-CoV-2 infection while on chemotherapy, questions are increasing about the approach for management of systemic immunosuppressive therapies, i.e. ceasing or reducing the immunosuppressive medications in children with leukemia.
The current rapid worldwide spread of COVID-19 necessitates identifying optimal preventive strategies and effective medical management. In this report, we tried to review appropriate literature-based approaches for prevention, diagnosis and management of treatment protocols for children with cancer during the pandemic period.

Project Number

yok

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There are 63 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section REVIEW
Authors

Arzu Yazal Erdem 0000-0003-1043-8471

Namık Yaşar Özbek 0000-0001-6857-0681

Project Number yok
Publication Date July 24, 2020
Submission Date May 28, 2020
Published in Issue Year 2020 COVID-19

Cite

Vancouver Yazal Erdem A, Özbek NY. SARS COV-2 Infection in Children with Leukemia. Türkiye Çocuk Hast Derg. 2020;14(COVID-19):41-7.


The publication language of Turkish Journal of Pediatric Disease is English.


Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.


The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.