Amaç: Yenidoğan ölümleri ve ağır morbiditelerini azaltan antenatal betametazon tedavisinin preterm bebeklerdeki serum tiroid hormonlarına etkisinin araştırılması amaçlanmıştır.
Gereç ve
Yöntemler: 2013-2019 yılları arasında doğan ve gebelik haftası 32 hafta ve altında olan ve çalışmaya alınma kriterlerini karşılayan toplam 156 bebek bu retrospektif çalışmaya alındı. Bebeklerin bilgilerine hastane kayıt sisteminden ulaşıldı. Bebekler hiç steroid almayan, tek doz alan ve tam doz alan olmak üzere üç gruba ayrıldı. Yaşamın 30. gününden önce bakılan tiroid fonksiyon testleri karşılaştırıldı.
Bulgular: Doğum haftası, doğum şekli, doğum ağırlığı, çoğul gebelik durumu, cinsiyet, anne yaşı, preeklampsi, erken membran rüptürü, koriyoamniyonit, annede tiroid hastalığı, bebeğin hastanede kalma süresi, tiroid testi örneklem zamanı, Apgar skoru, patent duktus arteriyozus, nekrotizan enterokolit, intraventriküler kanama, prematüre retinopatisi ve bronkopulmoner displazi oranı açısından her üç grup arasında fark saptanmadı. Tam doz steroid alanlarda surfaktan ihtiyacı anlamlı olarak düşüktü. Serum serbest tiroksin (sT4) ve tiroid uyarıcı hormon (TSH) düzeyleri açısından her üç grup arasında fark saptanmadı.
Sonuç: Bu çalışmada preterm bebeklerde antenatal betametazon profilaksisinin serum tiroid hormonlarına etkisinin olmadığı görülmüştür.
Objective: In this study, we aimed to investigate the effect of antenatal betamethasone treatment on serum thyroid hormones in preterm infants.
Material and Methods: A total of 156 babies born between 2013-2019 with gestational age of ≤32 weeks were included in this retrospective study. Information of the babies was accessed from the hospital records. Infants were divided into 3 groups according to betamethasone treatment: no treatment, partial dose, and complete dose. Thyroid function tests were compared between the groups before 30th days of life.
Results: There was no difference between the three groups in terms of gestational age, route of delivery, birth weight, rate of multiple pregnancy, gender, maternal age, premature rupture of membranes, chorioamnionitis, maternal thyroid disease, hospital stay, sampling time of serum thyroid hormones, Apgar score, patent ductus arteriosus, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity and bronchopulmonary dysplasia. The surfactant treatment was significantly low in the patients receiving complete dose of steroid. There was no difference between the three groups in terms of serum free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels.
Conclusion: It has been shown that antenatal betamethasone treatment has no effect on serum thyroid hormones in preterm infants.
Primary Language | Turkish |
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Subjects | Clinical Sciences |
Journal Section | ORIGINAL ARTICLES |
Authors | |
Publication Date | November 30, 2020 |
Submission Date | March 13, 2020 |
Published in Issue | Year 2020 Volume: 14 Issue: 6 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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