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İlk Komplike Febril Nöbet İle Gelen Hastalarda Klinik Bulgular ve EEG İle İlişkisi

Year 2021, Volume: 15 Issue: 6, 465 - 469, 26.11.2021
https://doi.org/10.12956/tchd.750635

Abstract

Amaç: Bu çalışmada hastanemize ilk komplike febril nöbet (FN) ile gelen hastaların dosya kayıtlarından demografik ve klinik bilgileri ile elektroensefalografi (EEG) özellikleri incelenerek EEG’de epileptik aktivite olup olmaması ile diğer kriterler arasında bir bağlantı olup olmadığını araştırmayı amaçladık.


Gereç ve Yöntemler
: Hatay Mustafa Kemal Üniversitesi Tıp Fakültesi Çocuk Nöroloji Polikliniği’ne 01/10/2019 – 01/05/2020 tarihleri arasında febril nöbet ile başvuran 256 hastanın dosyaları taranarak komplike olanların dosya bilgileri toplanıldı. EEG patolojisi olan ve olmayan iki grup demografik, klinik ve kranial görüntüleme özellikleri açısından karşılaştırıldı.


Bulgular:
Çalışmaya 25 hasta dahil edildi. Yaş ortalaması 26.4 ay olan 25 hastanın %60’ı erkekti, 15 (%60) hastanın nöbeti aynı gün içinde tekrarlamış, 16 (%64) hastanın nöbeti uzamış (>15 dakika), 2 hastanın nöbeti de fokal olarak izlenmiş. Hastaların %92’sinde jeneralize tonik klonik nöbet izlenirken, 2 (%8) hastada fokal nöbet meydana gelmişti. EEG traseleri incelendiği zaman 6 (%24) hastanın trasesinde interiktal epileptik deşarj mevcuttu. EEG’de interiktal epileptik deşarj saptanan hastaların tamamında deşarjlar fokal yerleşimliydi. EEG’ de interiktal epileptik deşarj saptanan grupta en sık görülen nöbet tipi (5/6) jeneralize nöbetlerdi. Komplike olma kriterlerine bakıldığında ise EEG’de interiktal epileptik deşarj olan hastalarda özellikle uzamış nöbetin daha sık (5/6) (%83.3) görüldüğünü tespit ettik.


Sonuç:
Çalışmamız özellikle ilk komplike FN şikayeti ile gelen hastaların yaklaşık ¼’ünde EEG’de interiktal epileptik deşarj (İED) saptandı. Bu hastalarda ise fokal interiktal epileptiform deşarjların ön planda olduğu görüldü. En sık komplike olma özelliği uzamış nöbetlerdi. EEG’de İED olan grupta en sık nöbet tipi ise jeneralize nöbetlerdi. EEG bozukluğu ile aile öyküsü ve nöbet özellikleri açısında herhangi bir bağlantı bulamadı. Bu nedenle ilk komplike FN ile gelen hastaların tamamına EEG çekilmesi önerilir.

References

  • 1 Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics 2008; 121:1281-6
  • 2 Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. I—Prevalence and recurrence in the first five years of life. Br Med J (Clin Res Ed). 1985;290(6478):1307–1310.
  • 3 Knudsen FU. Febrile seizures: treatment and outcome. Brain Dev 1996;18:438-49
  • 4 Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37: 126-33.
  • 5 Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Febrile Seizures. Pediatrics 1996;97:769-72.
  • 6 Whelan H, Harmelink M, Chou E, Sallowm D, Khan N, Patil R, Sannagowdara K, Kim JH, Chen WL, Khalil S, Bajic I, Keval A, Greydanus D. Complex febrile seizures-A systematic review. Dis Mon. 2017 Jan;63(1):5-23. doi: 10.1016/j.disamonth.2016.12.001. Epub 2017 Jan 12. Review
  • 7 Baumann RJ, Duffner PK. Treatment of children with simple febrile seizures: the AAP practice parameter. American Academy of Pediatrics. Pediatr Neurol. 2000;23:11-17.
  • 8 Harini C, Nagarajan E, Kimia AA, de Carvalho RM, An S, Bergin AM, Takeoka M, Pearl PL, Loddenkemper T. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov;52(Pt A):200-4. doi: 10.1016/j.yebeh.2015.09.003. Epub 2015 Oct
  • 9 Capovilla G,MastrangeloM, Romeo A, Vigevano F. Recommendation for the management of ‘‘febrile seizures’’: Ad Hoc Task Force of LICE Guidelines Commission. Epilepsia. 2009;50 Suppl 1:2-6.
  • 10 Nordli DR, Moshe SL, Shinnar S. The role of EEG in febrile status epilepticus (FSE). Brain Dev. 2010;32:37-41.
  • 11 Wo SB, Lee JH, Lee YJ, Sung TJ, Lee KH, Kim SK. Risk for developing epilepsy and epileptiform discharges on EEG in patients with febrile seizures. Brain Dev. 2013;35:307-311.

Clinical Findings and Their Relationship with EEG in Patients with the First Complicated Febrile Seizure

Year 2021, Volume: 15 Issue: 6, 465 - 469, 26.11.2021
https://doi.org/10.12956/tchd.750635

Abstract

Objective: In this study, we aimed to investigate whether there is a connection between the pathological EEG result and other criteria by examining the datas and electroencephalography (EEG) features of the patients who admitted to our hospital with the first complicated febrile seizure (FN).

Material and Methods: The datas of 256 patients who were admitted to Hatay Mustafa Kemal University Faculty of Medicine, Child Neurology Clinic with febrile seizures between 01/10/2019 - 01/05/2020 were collected. Two groups with and without EEG pathology were compared in terms of demographic, clinical, and cranial imaging features.

Results: 25 patients were included in the study. 60% of 25 patients with a mean age of 26.4 months were male, 15 (60%) patients had seizures repeated on the same day, 16 (64%) patients had prolonged seizures (> 15 minutes), and 2 patients’ seizures were observed focally. While 92% of the patients were followed by generalized tonic-clonic seizures, 2 (8%) patients had focal seizures. When the EEG traces were examined, 6 (24%) patients had a defect in their trace. Focal discharges were observed in all patients with disorder in EEG. The most common seizure type (5/6) in the group with EEG disorder was generalized seizures. Considering the complication criteria, we found that especially prolonged seizures were observed more frequently (5/6) (83.3%) in patients with EEG disorder.

Conclusion: Our study showed that focal interictal epileptiform discharges were the primary feature of EEG in patients with the first complicated FN complaint, and the most common complication was prolonged seizures. In the group with EEG disorder, the most common seizure type was generalized seizure, and the most common complication was prolonged seizures. He was not able to find any connection between EEG disorder and family history and seizure characteristics. For this reason, it is recommended that all patients who come with the first complicated FN should receive EEG.

References

  • 1 Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics 2008; 121:1281-6
  • 2 Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. I—Prevalence and recurrence in the first five years of life. Br Med J (Clin Res Ed). 1985;290(6478):1307–1310.
  • 3 Knudsen FU. Febrile seizures: treatment and outcome. Brain Dev 1996;18:438-49
  • 4 Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37: 126-33.
  • 5 Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Febrile Seizures. Pediatrics 1996;97:769-72.
  • 6 Whelan H, Harmelink M, Chou E, Sallowm D, Khan N, Patil R, Sannagowdara K, Kim JH, Chen WL, Khalil S, Bajic I, Keval A, Greydanus D. Complex febrile seizures-A systematic review. Dis Mon. 2017 Jan;63(1):5-23. doi: 10.1016/j.disamonth.2016.12.001. Epub 2017 Jan 12. Review
  • 7 Baumann RJ, Duffner PK. Treatment of children with simple febrile seizures: the AAP practice parameter. American Academy of Pediatrics. Pediatr Neurol. 2000;23:11-17.
  • 8 Harini C, Nagarajan E, Kimia AA, de Carvalho RM, An S, Bergin AM, Takeoka M, Pearl PL, Loddenkemper T. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov;52(Pt A):200-4. doi: 10.1016/j.yebeh.2015.09.003. Epub 2015 Oct
  • 9 Capovilla G,MastrangeloM, Romeo A, Vigevano F. Recommendation for the management of ‘‘febrile seizures’’: Ad Hoc Task Force of LICE Guidelines Commission. Epilepsia. 2009;50 Suppl 1:2-6.
  • 10 Nordli DR, Moshe SL, Shinnar S. The role of EEG in febrile status epilepticus (FSE). Brain Dev. 2010;32:37-41.
  • 11 Wo SB, Lee JH, Lee YJ, Sung TJ, Lee KH, Kim SK. Risk for developing epilepsy and epileptiform discharges on EEG in patients with febrile seizures. Brain Dev. 2013;35:307-311.
There are 11 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section ORIGINAL ARTICLES
Authors

Yılmaz Akbaş 0000-0003-3919-4685

Nuh Yılmaz 0000-0002-8538-1783

Publication Date November 26, 2021
Submission Date June 11, 2020
Published in Issue Year 2021 Volume: 15 Issue: 6

Cite

Vancouver Akbaş Y, Yılmaz N. İlk Komplike Febril Nöbet İle Gelen Hastalarda Klinik Bulgular ve EEG İle İlişkisi. Türkiye Çocuk Hast Derg. 2021;15(6):465-9.


The publication language of Turkish Journal of Pediatric Disease is English.


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