Research Article
BibTex RIS Cite

Malnutrition Status of Children with Celiac Disease

Year 2021, Volume: 15 Issue: 6, 526 - 530, 26.11.2021
https://doi.org/10.12956/tchd.847448

Abstract

Objective: In this study, we aimed to examine and evaluate the demographic data and malnutrition of patients we followed up with a diagnosis of CD.

Material and Methods: The files of 113 children aged between 2 and 18 years who were followed up with a diagnosis of CD from the Pediatric Gastroenterology Outpatient Clinic of our tertiary hospital were retrospectively analyzed. Diagnosis of CD; Patients with symptoms of the disease (abdominal pain, diarrhea, growth retardation, etc.), whose tissue transglutaminase values were positive, were examined by endoscopic method, and were classified according to the MARS classification, which was biopsied and made by the pathology clinic. The malnutrition status of these children was examined by looking at their calendar age, gender, weight and height, weight for age, weight for height, and body mass index (BMI). In addition, nutritional status was evaluated by looking at hemoglobin, ferritin, iron and vitamin B12 values.

Results: A total of 113 patients, 75 (66.4%) female and 38 (33.6%) male, who were diagnosed with CD and followed up were included in the study. When the weight values of the patients were examined, the 3rd percentile was 23%, the 3-10th percentile was 16.8%, the 10-25p was 16.8%, the 25-97th percentile was 41.6%, and the above 97th percentile was 1.8%. According to Gomez classification, mild malnutrition was 34.5%, moderate malnutrition 18.5% and heavy malnutrition 1.7%, weight for height was found to be mild 24.8%, moderate 3.5%, malnutrition, 16.8% according to BMI. Vitamin B12 deficiency was found 39%, low hemoglobin 22%, low ferritin 45% and iron deficiency 30%.

Conclusion: Malnutrition in CD continues to be an important problem. Malnutrition status in our study; Malnutrition was determined as 54.7% by weight for age, 28.3% for weight for height and 16.8% for BMI. Broader studies are required to minimize the negative effects of CD and related malnutrition in the world and in our country.

References

  • 1-Trancone R, Jabri B. Celiacdiseaseandglutensensitivity. J InternMed 2011;269:582-90.,Shahrooz R, Murray JA. Celiacdisease: newapproachestotherapy. AlimentPharmacolTher 2012; 35: 768–781
  • 2-Naiyana G, Hugh JF, Alan T. Celiacdisease: Prevalence, diagnosis,pathogenesisandtreatment World J Gastroenterol 2012;18):6036-59).
  • 3-Rampertab SD, Pooran N, Brar P, Singh P, Green PH. Trends in thepresentation of celiacdisease. Am J Med 2006; 119: 355.e9-14.
  • 4-Alleyne GAO, Hay RW, Picou DI, Stanfield J P & Whitehead R G. Protein-energyMalnutrition, FromeandLondon: Buttler&TannerLtd, 1979: 171- 4
  • 5-Grover Z, C Ee L. Protein energymalnutrition. Pediatr Clin North Am 2009;56:1055-58.
  • 6-Dipasquale V, Ugo Cucinotta U, Romano C. AcuteMalnutrition in Children: Pathophysiology, ClinicalEffectsandTreatment. Nutrients 2020;12:2413.
  • 7-Özdemir N, Çocuklarda tanıdan tedaviye demir eksikliği anemisi Türk Ped Arş 2015; 50: 11-9
  • 8-Waterlow JC. Classificationanddefinition of protein-caloriemalnutrition. BrMed J 1972;3:566-569. http://dx.doi.org/10.1136/bmj.3.5826.566 PMid:4627051 PMCid:1785878
  • 9-Waterlow JC, Buzina R, Keller W, Lane JM, Nichaman MZ, Tanner JM. Thepresentationanduse of heightandweightdataforcomparingthenutritionalstatus of groups of childrenundertheage of 10 years. Bull World Health Organ 1977;55:489-498. PMid:304391 PMCid:2366685
  • 10-Hill ID, Dirks MH, Liptak GS, Colletti, RB, Fasano, A, Guandalini, S. et al. Guidelineforthediagnosisandtreatment of celiacdisease in children: recommendations of theNorth AmericanSocietyforPediatricGastroenterology, HepatologyandNutrition. J Pediatr GastroenterolNutr 2005;40:1-19.
  • 11-Dalgic B, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A ve ark. TurkishCeliacStudyGroup. Prevalence of celiacdisease in healthyTurkishschoolchildren. Am J Gastroenterol 2011; 106: 1512-1517.
  • 12-Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB. Epidemiology of autoimmunediseases in Denmark. J Autoimmun. Epub 2007 Jun 19. PMID: 17582741; PMCID: PMC2717015.
  • 13-Kuloglu Z, Doganci T, Kansu A, Demirceken F, Duman M, Tutkak H, ve ark. HLA types in Turkish children with celiac disease. Turk JPediatr 2008;50: 515–20
  • 14-Emiroğlu HH, Emiroğlu E, Akbulut H, Eryılmaz A, Bayram RO, Yüksel A ve ark. Çölyak Hastalığı Tanısı ile İzlenen Çocuklarda Klinik Özellikler J CONTEMP MED 2017; 7(4): 333-339
  • 15-Castro-Antunes MM, Crovella S, Brandao LA, Guimaraes RL, Motta ME, Silva GA. Frequencydistribution of HLA DQ2 and DQ8 in celiac patients and first-degreerelatives in Recife, North eastern Brazil. Clinics (Sao Paulo) 2011;66: 227–31
  • 16-Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol 2001;96: 745-50
  • 17-Basturk A. Yılmaz R. Çölyak Hastalıklı Çocuk Hastalarımızın Retrospektif Olarak Değerlendirilmesi, Uludağ Üniversitesi Tıp Fakültesi Dergisi 42 (2-3) 79-82, 2016)
  • 18-Albayrak S, Doğan Y (2016). Çölyak Hastalığı Olan Çocukların Klinik Ve Laboratuvar Bulgularının Retrospektif Olarak Değerlendirilmesi 2016, Uzmanlık Tezi, Fırat Üniversitesi Tıp Fakültesi Çocuk Sağlığı Ve Hastalıkları Kliniği, Elazığ
  • 19-Mokhtari H, .Kuloğlu Z (2012). Çölyak Hastalığı Tanısı Alan Çocuklarda Şişmanlık Sıklığı Ve Glutensiz Diyetin Vücut Kitle İndeksine Etkisi Uzmanlık Tezi, Ankara Üniversitesi Tıp Fakültesi Çocuk Sağlığı Ve Hastalıkları Kliniği, Ankara

Çölyak Hastalığı Olan Çocukların Malnütrisyon Durumu

Year 2021, Volume: 15 Issue: 6, 526 - 530, 26.11.2021
https://doi.org/10.12956/tchd.847448

Abstract

Amaç: Bu çalışmada Çölyak Hastalığı (ÇH) tanısıyla izlediğimiz hastaların demografik verilerini ve malnütrisyon durumlarını inceleyip değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Üçüncü basamak hastanemizin Pediatrik Gastroenteroloji Polikliniğinden ÇH tanısı ile izlenen 2-18 yaş arasındaki 113 çocuk hastanın dosyaları retrospektif olarak incelendi. ÇH tanısı; hastalığa ait semptomları(karın ağrısı, ishal, malnütrüsyon vb) olan, doku transglutaminaz değerleri pozitif hastaların endoskopik yöntemle incelenip, biyopsi alınan ve patoloji kliniği tarafından yapılan MARS sınıflandırmasına göre konuldu.
Bu çocukların takvim yaşı, cinsiyet, ağırlık, boy değerlerine bakılarak yaşa göre ağırlık, boya göre ağırlık, vücut kitle indekslerine (VKI) bakılarak malnütrisyon durumlarına bakıldı. Ayrıca hemoglobin, ferritin, demir, vitamin B12 değerlerine bakılarak beslenme durumları değerlendirildi.


Bulgular:
Çalışmaya ÇH tanısı konulan ve takip edilen 75’i (%66.4) kız, 38’i (%33.6) erkek, toplam 113 hasta dâhil edildi. Hastaların yaşa göre ağırlık değerlerine bakıldığında 3 persentil altı %23.3-10 persentil arası %16.8, 10-25p %16.8, 25-97 persentil %41.6 ve 97 persentil üzeri %1.8 tespit edildi. Gomez sınıflamasına göre hafif malnütrüsyon %34.5, orta malnütrisyon %18.5 ve ağır malnütrisyon %1.7, boya göre ağırlık bakıldığında hafif %2 4.8, orta %3.5,malnütrisyon, VKİ göre %16.8 oranında zayıf olarak tespit edildi. Vitamin B12 eksikliği %39, hemoglobin düşüklüğü %22. ferritin düşüklüğü %45 ve demir eksikliği %30 tespit edildi.

Sonuç: ÇH’da ortaya çıkan malnütrisyon önemli bir sorun olmaya devam etmektedir. Çalışmamızda malnütrisyon durumu, yaşa göre ağırlık bakıldığında %54.7, boya göre ağırlık bakıldığında %28.3, VKI’ne göre %16.8 oranında malnütrisyon tespit edildi. Dünyada ve ülkemizde ÇH ve buna bağlı malnütrisyonun olumsuz etkilerini en aza indirmek için daha geniş çalışmalar yapmak gerekmektedir.

References

  • 1-Trancone R, Jabri B. Celiacdiseaseandglutensensitivity. J InternMed 2011;269:582-90.,Shahrooz R, Murray JA. Celiacdisease: newapproachestotherapy. AlimentPharmacolTher 2012; 35: 768–781
  • 2-Naiyana G, Hugh JF, Alan T. Celiacdisease: Prevalence, diagnosis,pathogenesisandtreatment World J Gastroenterol 2012;18):6036-59).
  • 3-Rampertab SD, Pooran N, Brar P, Singh P, Green PH. Trends in thepresentation of celiacdisease. Am J Med 2006; 119: 355.e9-14.
  • 4-Alleyne GAO, Hay RW, Picou DI, Stanfield J P & Whitehead R G. Protein-energyMalnutrition, FromeandLondon: Buttler&TannerLtd, 1979: 171- 4
  • 5-Grover Z, C Ee L. Protein energymalnutrition. Pediatr Clin North Am 2009;56:1055-58.
  • 6-Dipasquale V, Ugo Cucinotta U, Romano C. AcuteMalnutrition in Children: Pathophysiology, ClinicalEffectsandTreatment. Nutrients 2020;12:2413.
  • 7-Özdemir N, Çocuklarda tanıdan tedaviye demir eksikliği anemisi Türk Ped Arş 2015; 50: 11-9
  • 8-Waterlow JC. Classificationanddefinition of protein-caloriemalnutrition. BrMed J 1972;3:566-569. http://dx.doi.org/10.1136/bmj.3.5826.566 PMid:4627051 PMCid:1785878
  • 9-Waterlow JC, Buzina R, Keller W, Lane JM, Nichaman MZ, Tanner JM. Thepresentationanduse of heightandweightdataforcomparingthenutritionalstatus of groups of childrenundertheage of 10 years. Bull World Health Organ 1977;55:489-498. PMid:304391 PMCid:2366685
  • 10-Hill ID, Dirks MH, Liptak GS, Colletti, RB, Fasano, A, Guandalini, S. et al. Guidelineforthediagnosisandtreatment of celiacdisease in children: recommendations of theNorth AmericanSocietyforPediatricGastroenterology, HepatologyandNutrition. J Pediatr GastroenterolNutr 2005;40:1-19.
  • 11-Dalgic B, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A ve ark. TurkishCeliacStudyGroup. Prevalence of celiacdisease in healthyTurkishschoolchildren. Am J Gastroenterol 2011; 106: 1512-1517.
  • 12-Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB. Epidemiology of autoimmunediseases in Denmark. J Autoimmun. Epub 2007 Jun 19. PMID: 17582741; PMCID: PMC2717015.
  • 13-Kuloglu Z, Doganci T, Kansu A, Demirceken F, Duman M, Tutkak H, ve ark. HLA types in Turkish children with celiac disease. Turk JPediatr 2008;50: 515–20
  • 14-Emiroğlu HH, Emiroğlu E, Akbulut H, Eryılmaz A, Bayram RO, Yüksel A ve ark. Çölyak Hastalığı Tanısı ile İzlenen Çocuklarda Klinik Özellikler J CONTEMP MED 2017; 7(4): 333-339
  • 15-Castro-Antunes MM, Crovella S, Brandao LA, Guimaraes RL, Motta ME, Silva GA. Frequencydistribution of HLA DQ2 and DQ8 in celiac patients and first-degreerelatives in Recife, North eastern Brazil. Clinics (Sao Paulo) 2011;66: 227–31
  • 16-Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol 2001;96: 745-50
  • 17-Basturk A. Yılmaz R. Çölyak Hastalıklı Çocuk Hastalarımızın Retrospektif Olarak Değerlendirilmesi, Uludağ Üniversitesi Tıp Fakültesi Dergisi 42 (2-3) 79-82, 2016)
  • 18-Albayrak S, Doğan Y (2016). Çölyak Hastalığı Olan Çocukların Klinik Ve Laboratuvar Bulgularının Retrospektif Olarak Değerlendirilmesi 2016, Uzmanlık Tezi, Fırat Üniversitesi Tıp Fakültesi Çocuk Sağlığı Ve Hastalıkları Kliniği, Elazığ
  • 19-Mokhtari H, .Kuloğlu Z (2012). Çölyak Hastalığı Tanısı Alan Çocuklarda Şişmanlık Sıklığı Ve Glutensiz Diyetin Vücut Kitle İndeksine Etkisi Uzmanlık Tezi, Ankara Üniversitesi Tıp Fakültesi Çocuk Sağlığı Ve Hastalıkları Kliniği, Ankara
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section ORIGINAL ARTICLES
Authors

Haci Ballı 0000-0002-2879-8435

Selim Dereci 0000-0001-8689-3783

Abdulvahit Aşık 0000-0002-5508-1181

Publication Date November 26, 2021
Submission Date December 26, 2020
Published in Issue Year 2021 Volume: 15 Issue: 6

Cite

Vancouver Ballı H, Dereci S, Aşık A. Çölyak Hastalığı Olan Çocukların Malnütrisyon Durumu. Türkiye Çocuk Hast Derg. 2021;15(6):526-30.


The publication language of Turkish Journal of Pediatric Disease is English.


Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.


The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.