Abstract
Phenytoin is an antiepileptic agent that has been in clinical use for approximately 80 years, particularly due to its antiepileptic and antineuralgic activity and antiarrhythmic effects. Phenytoin has also become increasingly widely used in recent years in various clinical applications, including wound healing, migraine, dizziness, myocardial infarction, bipolar disorder, various types of ulcer, and burns. Vertigo/dizziness is frequently seen in children. Numerous causes play a role in the etiology of vertigo/dizziness. Antiepileptic drugs (particularly carbamazepine and diphenylhydantoin) are also known to give rise to vertigo/dizziness. There are no specific studies concerning the treatment of vertigo/dizziness in childhood, and treatment is reported to involve treatment of the underlying etiology.
References
- Dilber B, Aydın ZGG, Yeşilbaş O, Sağ E, Aksoy NK, Gündoğmuş F, et al. Neurological Manifestations of Pediatric Acute COVID Infections: A Single Center Experience. Journal of Tropical Pediatrics 2021;67(3):1-9.
- Asadi-Pooya AA. Seizures associated with coronavirus infections. Seizure 2020;79(July):49–52.
- Fırat O, Yalçın N, Demirkan K. COVID-19 & antiepileptic drugs: Should we pay attention? Seizure 2020 Aug;80:240-241.
- Abou-Khalil BW. Antiepileptic Drugs. Continuum (Minneap Minn) 2016 Feb;22(1 Epilepsy):132-56.
- Yaari Y, Selzer ME, Pincus JH. Phenytoin: mechanisms of its anticonvulsant action. Ann Neurol 1986;20(2):171-84.
- Patocka J, Wu Q, Nepovimova E, et al. Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology. Food Chem Toxicol 2020 Aug;142:111393.
- Keppel Hesselink JM, Kopsky DJ. Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. J Neurol 2017 Aug;264(8):1617-21.
- Keppel Hesselink JM, Kopsky DJ. Phenytoin: neuroprotection or neurotoxicity? Neurol Sci 2017 Jun;38(6):1137-41.
- Keppel Hesselink JM. Phenytoin repositioned in wound healing: clinical experience spanning 60 years. Drug Discov Today 2018 Feb;23(2):402-8.
- Russel G, Abu-Arafeh I. Paroxysmal vertigo in children- an epidemiological study. Int J Pediatr Otorhinolaryngol 1999;49(1):105–7.
- Various Vertigo Syndromes. In: Vertigo and Dizziness. Springer, London 2005 https://doi.org/10.1007/1-84628-081-8_6
Abstract
Fenitoin, özellikle antiepileptik, antinöraljik aktivitesi ve antiaritmik etkileri nedeniyle yaklaşık 80 yıldır klinik kullanımda olan bir antiepileptik ajandır. Fenitoin ayrıca son yıllarda yara iyileşmesi, migren, baş dönmesi, miyokard enfarktüsü, bipolar bozukluk, ülser türleri ve yanıklar dahil olmak üzere çeşitli klinik uygulamalarda giderek daha yaygın bir şekilde kullanılmaktadır. Çocuklarda baş dönmesi sıklıkla görülür. Baş dönmesi etyolojisinde çok sayıda neden rol oynamaktadır. Antiepileptik ilaçların da (özellikle karbamazepin ve difenilhidantoin) baş dönmesine neden olduğu bilinmektedir. Çocukluk çağında baş dönmesi tedavisi ile ilgili spesifik bir çalışma yoktur ve tedavinin altta yatan etyolojinin tedavisini içerdiği bildirilmektedir.
References
- Dilber B, Aydın ZGG, Yeşilbaş O, Sağ E, Aksoy NK, Gündoğmuş F, et al. Neurological Manifestations of Pediatric Acute COVID Infections: A Single Center Experience. Journal of Tropical Pediatrics 2021;67(3):1-9.
- Asadi-Pooya AA. Seizures associated with coronavirus infections. Seizure 2020;79(July):49–52.
- Fırat O, Yalçın N, Demirkan K. COVID-19 & antiepileptic drugs: Should we pay attention? Seizure 2020 Aug;80:240-241.
- Abou-Khalil BW. Antiepileptic Drugs. Continuum (Minneap Minn) 2016 Feb;22(1 Epilepsy):132-56.
- Yaari Y, Selzer ME, Pincus JH. Phenytoin: mechanisms of its anticonvulsant action. Ann Neurol 1986;20(2):171-84.
- Patocka J, Wu Q, Nepovimova E, et al. Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology. Food Chem Toxicol 2020 Aug;142:111393.
- Keppel Hesselink JM, Kopsky DJ. Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. J Neurol 2017 Aug;264(8):1617-21.
- Keppel Hesselink JM, Kopsky DJ. Phenytoin: neuroprotection or neurotoxicity? Neurol Sci 2017 Jun;38(6):1137-41.
- Keppel Hesselink JM. Phenytoin repositioned in wound healing: clinical experience spanning 60 years. Drug Discov Today 2018 Feb;23(2):402-8.
- Russel G, Abu-Arafeh I. Paroxysmal vertigo in children- an epidemiological study. Int J Pediatr Otorhinolaryngol 1999;49(1):105–7.
- Various Vertigo Syndromes. In: Vertigo and Dizziness. Springer, London 2005 https://doi.org/10.1007/1-84628-081-8_6
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Letter to Editor |
| Authors | |
| Publication Date | January 28, 2022 |
| Submission Date | October 2, 2021 |
| Published in Issue | Year 2022 Volume: 16 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.