COVID-19 Salgını Sırasında Doğuştan Bağışıklık Yetersizliği Olan Ergenlerde Psikososyal İşlevsellik

Year 2024, Volume: 18 Issue: 3, 166 - 173, 13.05.2024

Ayşe Gül Güven , Saliha Esenboğa Melis Pehlivantürk Kızılkan , Cihan Aslan , Ayşegül Akarsu Erdem Karabulut , Devrim Akdemir , Nuray Öksüz Kanbur , Deniz Ayvaz , İlhan Tezcan Orhan Derman

https://doi.org/10.12956/tchd.1374480

Abstract

Amaç: Bu çalışma, doğuştan bağışıklık yetersizliği olan ergenlerin psikososyal işlevleri üzerinde COVİD-19’un etkisini belirlemeyi amaçlamıştır.
Gereç ve Yöntemler: Bu çalışmaya 36 doğuştan bağışıklık yetersizlik hastası (18 hafif, 18 şiddetli) ve yaşları 10-17 arasında 18 sağlıklı kontrol dahil edildi. Ergenler ve onların ebeveynleri, kaygı ve depresyon semptomlarını ölçmek için Gözden Geçirilmiş Çocuk Kaygısı ve Depresyon Ölçeği’ni (RCADS) ve sosyal davranışları ve duygusal/davranışsal sorunları değerlendirmek için Güçler Güçlükler Anketi’ni (SDQ) doldurdu. Ek olarak, ergenler tarafından koronavirüs fobisinin düzeyini değerlendirmek amacıyla COVİD-19 Fobi Ölçeği (C19P-S) yanıtlandı.
Bulgular: SDQ’ya göre kontrol grubundaki ergenlerin duygusal puanları hafif/ağır hasta grubuna göre daha yüksekti. Ağır hasta grubunun emosyonel puanları hafif gruba göre daha yüksekti. RCADS ebeveyn ve ergen skorlarına göre, kontrol grubunun depresyon puanları ve ebeveynlerin sosyal fobi puanları hafif gruba göre anlamlı derecede yüksekti.
Sonuç: Bu çalışma sonuçlarına göre sağlıklı ergenlerin psikiyatrik belirti skorları, özellikle hafif doğuştan bağışıklık yetersizliği olan ergenlere göre daha yüksektir. Doğuştan bağışıklık yetersizlikli ergenlerin pandemiden önceki dönemde sağlıkla ilgili zorluklara maruz kalmalarının dayanıklılık geliştirmelerine yardımcı olduğunu düşünüyoruz. Pandeminin bu savunmasız ergen popülasyonunun ruh sağlığı üzerindeki uzun vadeli etkilerini değerlendirmek için uzun vadeli ve daha büyük çalışmalara ihtiyaç vardır.

Keywords

doğuştan gelen bağışıklık hataları, COVİD-19 Salgını, ruh sağlığı, ergenler

Psychosocial Functionality in Adolescents with Inborn Errors of Immunity During the COVID-19 Pandemic

Abstract

Objective: We aimed to determine the impact of COVID-19 on the psychosocial functioning of adolescents with inborn errors of immunity (IEI).
Material and Methods: Thirty-six patients with IEI (18 mild, 18 severe) and 18 healthy controls aged between 10 and 17 were included in this study. Adolescents and their caregivers completed the Revised Child Anxiety and Depression Scale (RCADS) to measure symptoms of anxiety and depression and the Strengths and Difficulties Questionnaire (SDQ) to assess prosocial behaviors and emotional/behavioral problems. Additionally, the COVID-19 Phobia Scale (C19P-S) was answered by adolescents to assess the level of coronavirus phobia.
Results: According to SDQ, emotional scores of the adolescents in the control group are higher than the mild/severe patient group. Emotional scores of the severe patient group are higher than the mild group. The RCADS parent- and adolescent-reported depression scores and parent-reported social phobia scores of the control group were significantly higher than the mild group.There were no statistically significant differences between the groups according to COVID-19 Phobia Scale.
Conclusion: The healthy adolescents had higher psychiatric symptom scores, especially than the adolescents with mild IEI. We suggest that being exposed to health-related challenges even before the pandemics in adolescents with IEI helped them develop psychological resilience. Longitudinal and larger studies are needed to evaluate the long-term effects of the pandemic on the mental health of this vulnerable adolescent population.

Keywords

inborn errors of immunity, COVID-19 Pandemic, mental health, adolescents.

References

• Ludvigsson JF. Systematic review of COVİD-19 in children show milder cases and better prognosis than adults. Acta Pediatr 2020; 109:1088-95.
• PCM Williams, AR Howard-Jones, P Hsu, Palasanthiran P, Gray PE, McMullan BJ, et al. SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings. Pathology 2020; 52:801-8.
• Williamson EJ, Walker AJ, Bhaskara K, Bacon S, Bates C, Morton CE, et al. OpenSAFELY: factors associated with COVID-19 death in 17 million patients. Nature 2020; 584:430-6.
• Meyts I, Bucciol G, I Quinti I, Neven B, Fischer A, Seoane E, et al. Coronavirus disease 2019 in patients with inborn errors of immunity: An international study. J Allergy Clin Immunol 2021;147:520-31.
• Esenboga S, Ocak M, Akarsu A, Bildik HN, Çağdaş D, Topeli A, et al. COVID-19 in Patients with Primary Immunodeficiency. Journal of Clin Immunol 2021;41:1515-22.
• Burhamah W, Alkhayyat A, Oroszlanyova M, Kenane A, Almansouri A, Behbehani M, et al. The psychological burden of the COVID-19 pandemic and associated lockdown measures: Experience from 4000 participants. J. Affect Disord 2020; 277:977-85.
• Lindoso L, Astley C, Bruni Queiroz L, Gualano B, Pereira RMR, Tannuri U, et al. Physical and mental health impacts during COVID-19 quarantine in adolescents with preexisting chronic immunocompromised conditions. J Pediatr 2022; 98: 350-61.
• Kuburovic NB, Pasic S, Susic G, Stevanovic D, Kuburovic V, Zdravkovic S, et al. Health-related quality of life, anxiety, and depressive symptoms in children with primary immunodeficiencies. Patient Prefer Adherence 2014; 8:323-30. Titman P, Allwood Z, Gilmour C, Malcolmson C, Duran-Persson C, Cale C, et al. Quality of Life in Children with Primary Antibody Deficiency. J Clin Immunol 2014;34:844-52.
• Suris JC, Michaud PA, Viner R. The adolescent with a chronic condition. Part I: developmental issues. Arch Dis Child 2004; 89: 938-42.
• Yılmaz Topal Ö, Metin A, Çöp E, Şenses Dinç G, Şükran Üneri Ö. Anxiety among the parents of pediatric patients receiving IVID therapy during COVID-19 Pandemic. Turkish J Pediatr Dis 2021; 63: 801-10.
• Akdağ B, Önder A, Gizli Çoban Ö, Kocacık Uygun DF, Sürer Adanır A, Erdem A, et al. Psychological State of Parents of Children with Primary Immunodeficiencies During the COVID-19 Pandemic. Pediatric Allergy Immunol Pulmonol 2022; 35:12-8.
• Seidel MG, Kindle G, Gathman B, Quinti I, Buckland M, van Montfrans J, et al. The European Society for Immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract 2019; 7: 1763-70.
• Chorpita BF, Yim L, Moffitt C, Umemoto AL, Francis ES. Assessment of symptoms of DSM-IV anxiety and depression in children: a Revised Child Anxiety and Depression Scale. Behav Res Ther 2000; 38: 835–55.
• Gormez V, Kılınçaslan A, Orengul AC, Ebesutani CE, Kaya İ, Ceri V, et al. Psychometric properties of the Turkish version of the Revised Child Anxiety and Depression Scale – Child Version in a clinical sample. Psychiatry Clin Psychopharmacol 2017; 27: 84-92.
• Goodman R. The Strengths and Difficulties Questionnaire: A research note. J Child Psychol Psychiatry 1997;38:581-6.
• Güvenir T, Özbek A, Baykara B, Arkar H, Şentürk B, İncekaş S. Psychometric Properties of the Turkish Version of The Strengths and Difficulties Questionnaire (SDQ) Turk J Child Adolesc Ment Health 2008;15: 65-74
• Arpaci İ, Karatas Ķ, Baloğlu M. The development and initial tests for the psychometric properties of the COVID-19 Phobia Scale (C19P-S). Pers Individ Dif 2020; 164: 110108.
• Cole TS, Jones L, Mc Grogan P, Pearce MS, Flood TJ, Cant AJ, et al. Emotional and behavioral difficulties in chronic granulomatosus disease. Arch Dis Child 2012; 97: 87.
• Kayan Ocakoğlu B, Edeer Karaca N, Ocakoğlu FT, Erermis S. Psychological burden of pediatric primary immunodeficency. Pediatr Int 2018; 60: 911-7.
• Piazza-Waggoner C, Adams CD, Cottrell L, Taylor BK, Wilson NW, Hogan MB. Child and caregiver psychosocial functioning in pediatric immunodeficiency disorders. Ann Allergy Asthma Immunol 2006; 96: 298-303.
• Kılıç AO, Uzun N, Akın F, Akıncı MA, Yazar A, Bozkurt Alan H, et al. The Effects of COVİD-19 pandemic on Mental Health in Children with Primary Immunodeficiency. Pediatr Pract Res 2022; 10: 83-8.
• Senkalfa BP, Sismanlar Eyuboglu T, Aslan AT, Ramaslı Gursoy T, Soysal AS, et al. Effect of the COVİD-19 pandemic on anxiety among children with cyctic fibrosis and their mothers. Pediatr Pulmonol 2020; 55: 2128-34.
• Melissa Bernstein, Betty Pfefferbaum. Posttraumatic Growth as a Response to Natural Disasters in Children and Adolescents. Curr Pschiatry Rep 2018; 20:37.
• Picoraro JA, Wormer WJ, Kazak AE, Feudtner C. Posttraumatic Growth İn Parents. J Palliat Med 2014;17:209-18.
• Constanzo ES, Ryff C, Singer BH. Psychosocial adjustment among cancer survivors: Findings from a national survey of health and well-being. Health Psychol 2009;28: 147-56.
• Rutter M. Implications of resilience concepts for scientific understanding. Ann N Y Acad Sci 2006; 1094: 1-12.
• Kemper TS, Gerhardstein R, Repper KK, Kistner JA. Mother-Child Agreement on Reports of Internalizing Symptoms Among Children Referred for Evaluation of ADHD. J Psychopathol Behav Assess 2003; 25: 239-49.
• Choudhury MS, Pimentel SS, Kendall PC. Childhood anxiety disorders: parent-child (dis)agreement using a structured interview for the DSM-IV. J Am Acad Child Adolesc Psychiatr 2003; 42: 957-63.
• Sourander A, Hestela L, Helenius H. Parent-adolescent agreement on emotional and behavioral problems. Soc. Psychiatr Epidemol 1999; 34: 657-63.