Amaç: Proton pompa inhibitörleri Helicobacter pylori kolonizasyonunu önemli ölçüde azaltarak aktivitesinde ve inflamasyonda azalma sağlar. Proton pompası inhibitörü tedavisinden 28 gün sonra başlatılan eradikasyonun ve proton pompası inhibitörü tedavisiyle eş zamanlı başlatılan eradikasyonun Helicobacter pylori tedavi başarı oranlarına etkisini araştırdık.
Gereç ve Yöntemler: Araştırma, üçüncü basamak tedavi merkezi olan hastanemizde gerçekleştirildi; burada çalışma grubundaki 42 hastaya 28 gün boyunca oral lansoprazol tedavisi ve ardından eradikasyon tedavisi verildi, kontrol grubundaki 41 hastaya ise her iki tedavi aynı anda verildi. Eradikasyon başarısı Helicobacter pylori poliklonal antijen dışkı testi kullanılarak değerlendirildi.
Bulgular: Çalışmamıza yaşları 8 ile 18 arasında değişen ve Helicobacter pylori pozitif olan toplam 83 katılımcı dahil edildi. Katılımcıların ortalama yaşı 15.14±2.01’di. Helicobacter pylori iyileşme oranı çalışma grubunda %92.9, kontrol grubunda ise %92.7 olarak bulundu. Helicobacter pylori’nin eradikasyonu açısından iki grup arasında anlamlı bir fark gözlenmedi (p=0.976).
Sonuç: Çocuklarda modifiye proton pompa inhibitörü kullanımı ile Helicobacter pylori tedavisi başarı oranlarında anlamlı bir fark bulunamadı.
Objective: Proton pump inhibitors significantly reduce Helicobacter pylori colonization and provide recovery in its activity and inflammation. We investigated; the effects of eradication initiated 28 days after proton pump inhibitor treatment and eradication initiated simultaneously with proton pump inhibitor treatment, on treatment success rates of Helicobacter pylori.
Material and Methods: The study took place at our tertiary care hospital, where 42 patients in the study group were given oral lansoprazole treatment for 28 days followed by eradication treatment and 41 patients in the control group were given both treatments simultaneously. Eradication success was monitored using Helicobacter pylori polyclonal antigen stool tests.
Results: A total of 83 participants, aged between 8 and 18 years, tested positive for Helicobacter pylori. The mean age of the participants was 15.14 ± 2.01 years. The Helicobacter pylori cure rate was found to be 92.9% in the study group and 92.7% in the control group. There were no significant differences observed between the two groups in terms of eradicating Helicobacter pylori (p=0.976).
Conclusion: We found no significant differences in Helicobacter pylori treatment success rates with modified proton pump inhibitor usage in children.
Primary Language | English |
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Subjects | Clinical Sciences (Other) |
Journal Section | ORIGINAL ARTICLES |
Authors | |
Early Pub Date | May 23, 2024 |
Publication Date | September 24, 2024 |
Submission Date | February 23, 2024 |
Acceptance Date | April 24, 2024 |
Published in Issue | Year 2024 Volume: 18 Issue: 5 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 6 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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