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Evaluation of Secondary Dyslipidemia in Obese Children

Year 2024, Volume: 18 Issue: 6, 355 - 359, 18.11.2024
https://doi.org/10.12956/tchd.1447454

Abstract

Objective: This study was conducted to determine the frequency of dyslipidemia secondary to childhood obesity, a recently emerging clinical entity, and to compare serum lipid profiles in obese and non-obese children.

Material and Methods: After screening children with an obese appearance, a group of 119 obese children aged between 2 to 16 years with a body mass index above the 95th percentile and a control group of 124 children in a similar age range were compared in terms of serum lipid profile.

Results: An abnormal lipid profile was determined in 62.6% of obese children, and serum levels of total cholesterol and triglycerides were higher in this group. It was found that Childhood obesity was associated with higher levels of total cholesterol (44.5%), triglycerides (48.7%), LDL (38.7%), and lower levels of HDL (23.5%).

Conclusion: Obese children have a higher risk of secondary dyslipidemia and associated comorbidities. In order to prevent childhood obesity and its dangerous consequences, effective measures must be implemented in terms of screening, early diagnosis and appropriate treatment.

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References

  • Demiray G, Yorulmaz F. Obesity Management with A Public Health Perspective. Value Health Sci 2023;13:147-55.
  • Günöz H. Şişmanlık. Neyzi O, Ertuğrul T (Ed.). Pediyatri. 4th ed. İstanbul, Nobel Tıp Kitabevi 2010;1:251-7.
  • Esmer O. Somatotip yapıya uygun egzersizlerin obezite tedavisine etkileri. 1st ed. Ankara, Detay Yayıncılık, 2018.
  • Berberoğlu Z and Hocaoğlu Ç. Global Health Problem ‘Obesity’: A Current Review”. CBU-SBED 2021;8:543-52.
  • Gahagan S. Overweight and Obesity. in Nelson Textbook of Pediatrics. Kliegman RM, Geme ST, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Elsevier 2022:179-88.
  • Deleş B. Childhood Obesity. Hacettepe University Faculty of Health Sciences Journal 2019;6:17-31.
  • Apperley LJ, Blackburn J, Erlandson-Parry K, Gait L, Laing P, Senniappan S. Childhood obesity: A review of current and future management options. Clin Endocrinol (Oxf) 2022;96:288-301.
  • Radaelli G, Sausen G, Cesa CC, Portal VL, Pellanda LC. Secondary Dyslipidemia In Obese Children-Is There Evidence For Pharmacological Treatment?. Arq Bras Cardiol 2018;111:356-61.
  • Vehrs PR, Fellingham GW, McAferty A, Kelsey L. Trends in BMI Percentile and Body Fat Percentage in Children 12 to 17 Years of Age. Children (Basel) 2022;9:744.
  • Paoli M, Uzcátegui L, Zerpa Y, Gómez-Pérez R, Camacho N, Molina Z, et al. Obesity in schoolchildren from Merida, Venezuela: association with cardiovascular risk factors. Endocrinol Nutr 2009;56 :218–26.
  • Spinelli A, Buoncristiano M, Kovacs VA, Yngve A, Spiroski I, Obreja G, et al. Prevalence of Severe Obesity among Primary School Children in 21 European Countries. Obes Facts 2019;12:244-58.
  • Çatlı G, Büyükgebiz A. Çocuk ve ergenlerde obezite: Tanım ve Epidemiyoloji. Türkiye Klinikleri J Pediatr Sci 2015;11:7-21.
  • Akış N, Pala K, İrgil E, Aydın N, Aksu H. Overweight And Obesity Among 6- 14 Year- Aged Schoolchildren At Six Elementary Schools in Orhangazi-Bursa. Uludağ Tıp Derg 2003;29;17-20.
  • Yüce Hİ. Okul çocuklarında metabolik sendrom risk faktörü olarak obezite ve hipertansiyon taraması. İstanbul. (Yayımlanmamış uzmanlık tezi): T.C. Sağlık Bakanlığı Şişli Etfal Eğitim ve Araştırma Hastanesi 2007.
  • Alpcan A, Durmaz ŞA. Giant problem of our era: childhood obesity. TJCL 2015; 6:30-8.
  • Mulligan J. Standard definition of child overweight and obesity worldwide. Body mass index is harder to interpret in children than adults. BMJ 2000; 321: 1158.
  • Lambrinou CP, Androutsos O, Karaglani E, Cardon G, Huys N, Wikström K, et al. Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel 4 Diabetes-study school based component. BMC Endocr Disord 2020; 20:52.
  • Obezite ,TEMD, and Hipertansiyon Çalışma Grubu. “Obezite tanı ve tedavi kılavuzu 2019, 8. baskı.” Ankara, Türkiye Endokrinoloji ve Metabolizma Derneği 2019:59-62.
  • Brown T, Moore TH, Hooper L, Gao Y, Zayegh A, Ijaz S, et al. Interventions for preventing obesity in children. Cochrane Database Sys Rev 2019;7:CD001871.
  • Valerio G, Maffeis C, Saggese G, Ambruzzi MA, Balsamo A, Bellone S, et al. Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics. Ital J pediatr 2018; 44: 1-21.

Obez Çocuklarda Sekonder Dislipidemi Sıklığının Araştırılması

Year 2024, Volume: 18 Issue: 6, 355 - 359, 18.11.2024
https://doi.org/10.12956/tchd.1447454

Abstract

Amaç: Bu çalışma, çocukluk çağı obezitesine sekonder gelişen dislipideminin sıklığını belirlemek ve obez çocuklarla obez olmayan çocukların lipid profillerini karşılaştırmak amacıyla yapılmıştır.

Gereç ve Yöntemler: Obez görünümlü çocuklar taranarak saptanan, yaş aralığı 2-16 arasında ve vücut kitle indeksi 95. persentil eğrisi üzerinde olan 119 obez olgudan oluşan grup ve benzer yaş aralığındaki 124 olgudan oluşan kontrol grubu, serum lipid profili bakımından karşılaştırılmıştır.

Bulgular: Bulgularımıza göre anormal lipid profili obez çocuklarda %62.6 oranında saptandı ve total kolesterol ile trigliserid düzeyleri kontrol grubuna göre daha yüksekti. Çocuklarda obezite, total kolesterol yüksekliği (%44.5), trigliserid yüksekliği (%48.7), LDL yüksekliği (%38.7) ve HDL düşüklüğü (%23.5) ile ilişkili bulundu.

Sonuç: Obez çocuklar sekonder dislipidemi ve ilişkili hastalıklar açısından risk altındadır. Obezite ve dislipideminin komplikasyonlarını önlemek amacıyla çocukluk çağı obezitesine yönelik tarama, erken teşhis ve uygun tedavinin başlanması önem taşımaktadır.

References

  • Demiray G, Yorulmaz F. Obesity Management with A Public Health Perspective. Value Health Sci 2023;13:147-55.
  • Günöz H. Şişmanlık. Neyzi O, Ertuğrul T (Ed.). Pediyatri. 4th ed. İstanbul, Nobel Tıp Kitabevi 2010;1:251-7.
  • Esmer O. Somatotip yapıya uygun egzersizlerin obezite tedavisine etkileri. 1st ed. Ankara, Detay Yayıncılık, 2018.
  • Berberoğlu Z and Hocaoğlu Ç. Global Health Problem ‘Obesity’: A Current Review”. CBU-SBED 2021;8:543-52.
  • Gahagan S. Overweight and Obesity. in Nelson Textbook of Pediatrics. Kliegman RM, Geme ST, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Elsevier 2022:179-88.
  • Deleş B. Childhood Obesity. Hacettepe University Faculty of Health Sciences Journal 2019;6:17-31.
  • Apperley LJ, Blackburn J, Erlandson-Parry K, Gait L, Laing P, Senniappan S. Childhood obesity: A review of current and future management options. Clin Endocrinol (Oxf) 2022;96:288-301.
  • Radaelli G, Sausen G, Cesa CC, Portal VL, Pellanda LC. Secondary Dyslipidemia In Obese Children-Is There Evidence For Pharmacological Treatment?. Arq Bras Cardiol 2018;111:356-61.
  • Vehrs PR, Fellingham GW, McAferty A, Kelsey L. Trends in BMI Percentile and Body Fat Percentage in Children 12 to 17 Years of Age. Children (Basel) 2022;9:744.
  • Paoli M, Uzcátegui L, Zerpa Y, Gómez-Pérez R, Camacho N, Molina Z, et al. Obesity in schoolchildren from Merida, Venezuela: association with cardiovascular risk factors. Endocrinol Nutr 2009;56 :218–26.
  • Spinelli A, Buoncristiano M, Kovacs VA, Yngve A, Spiroski I, Obreja G, et al. Prevalence of Severe Obesity among Primary School Children in 21 European Countries. Obes Facts 2019;12:244-58.
  • Çatlı G, Büyükgebiz A. Çocuk ve ergenlerde obezite: Tanım ve Epidemiyoloji. Türkiye Klinikleri J Pediatr Sci 2015;11:7-21.
  • Akış N, Pala K, İrgil E, Aydın N, Aksu H. Overweight And Obesity Among 6- 14 Year- Aged Schoolchildren At Six Elementary Schools in Orhangazi-Bursa. Uludağ Tıp Derg 2003;29;17-20.
  • Yüce Hİ. Okul çocuklarında metabolik sendrom risk faktörü olarak obezite ve hipertansiyon taraması. İstanbul. (Yayımlanmamış uzmanlık tezi): T.C. Sağlık Bakanlığı Şişli Etfal Eğitim ve Araştırma Hastanesi 2007.
  • Alpcan A, Durmaz ŞA. Giant problem of our era: childhood obesity. TJCL 2015; 6:30-8.
  • Mulligan J. Standard definition of child overweight and obesity worldwide. Body mass index is harder to interpret in children than adults. BMJ 2000; 321: 1158.
  • Lambrinou CP, Androutsos O, Karaglani E, Cardon G, Huys N, Wikström K, et al. Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel 4 Diabetes-study school based component. BMC Endocr Disord 2020; 20:52.
  • Obezite ,TEMD, and Hipertansiyon Çalışma Grubu. “Obezite tanı ve tedavi kılavuzu 2019, 8. baskı.” Ankara, Türkiye Endokrinoloji ve Metabolizma Derneği 2019:59-62.
  • Brown T, Moore TH, Hooper L, Gao Y, Zayegh A, Ijaz S, et al. Interventions for preventing obesity in children. Cochrane Database Sys Rev 2019;7:CD001871.
  • Valerio G, Maffeis C, Saggese G, Ambruzzi MA, Balsamo A, Bellone S, et al. Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics. Ital J pediatr 2018; 44: 1-21.
There are 20 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section ORIGINAL ARTICLES
Authors

Selma Çakmakcı 0000-0002-4824-3023

Feyza Yıldız 0000-0002-8684-0101

Early Pub Date July 31, 2024
Publication Date November 18, 2024
Submission Date March 5, 2024
Acceptance Date May 22, 2024
Published in Issue Year 2024 Volume: 18 Issue: 6

Cite

Vancouver Çakmakcı S, Yıldız F. Evaluation of Secondary Dyslipidemia in Obese Children. Türkiye Çocuk Hast Derg. 2024;18(6):355-9.


The publication language of Turkish Journal of Pediatric Disease is English.


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