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Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

Year 2023, , 99 - 104, 27.09.2023
https://doi.org/10.46810/tdfd.1291880

Abstract

Alzheimer's disease affects all tissues negatively. In this study, it was aimed to determine the effects of TQ on testicular toxicity in rats with experimental Alzheimer's disease. In the study, 33 Wistar Albino rats weighing 190-230 gr were used. Rats were 11 rats in each group; were divided into 3 equal groups as control, ALZ and ALZ+TQ. The control group was given saline by IP route for 28 days daily. The ALZ group was given 60 mg/kg D-gal + 40 mg/kg AlCl3 IP for 28 days daily. The ALZ+TQ group was given 60 mg/kg D-gal + 40mg/kg AlCl3 for 28 days by IP + 20 mg/kg TQ by oral gavage for last 14 days daily. According to the findings of our study, a decrease in SOD, CAT, GPx activity and GSH levels and an increase in MDA levels were determined in the ALZ group. In the ALZ+TQ group, while SOD, GPx, CAT activities and GSH levels increased, MDA levels decreased. Semen analyzes showed that there was a decrease in sperm motility and sperm density in the ALZ group, and an increase in the rate of abnormal sperm and dead spermatozoa. In the ALZ+TQ group, sperm motility, abnormal sperm rate and dead spermatozon rate improved. As a result, it was determined that the decrease in semen quality and increase in oxidative stress induced by AlCl3+D-Gal were suppressed by TQ, protecting the testicular tissue from oxidative damage and increasing semen quality.

References

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  • [3] Ahmed SA, Mohammed WI. Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats. Biomedicine & Pharmacotherapy. 2021;139:111594.
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  • [7] Klein J, Mold M, Mery L, Cottier M, Exley C. Aluminum content of human semen: Implications for semen quality. Reproductive Toxicology. 2014;50:43-8.
  • [8] Güvenç M, Cellat M, Gökçek İ, Arkalı G, Uyar A, Tekeli İO, et al. Tyrosol prevents AlCl3 induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway. Andrologia. 2020;52(2):e13499.
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  • [21] Gökçe A, Oktar S, Koc A, Yonden Z. Protective effects of thymoquinone against methotrexate-induced testicular injury. Human & experimental toxicology. 2011;30(8):897-903.
  • [22] Gür FM, Timurkaan S, Taskin E, Guven C, Gur HE, Senturk M, et al. Thymoquinone improves testicular damage and sperm quality in experimentally varicocele‐induced adolescent rats. Andrologia. 2021;53(5):e14033.
  • [23] Hassan E, El-Neweshy M, Hassan M, Noreldin A. Thymoquinone attenuates testicular and spermotoxicity following subchronic lead exposure in male rats: Possible mechanisms are involved. Life sciences. 2019;230:132-40.
  • [24] Akarsu GD, Çetin A. The Effect of Thymoquinone on Oxidative Stress Parameters and Apolipoprotein E in Alzheimer Model in Rats. Dementia and Geriatric Cognitive Disorders. 2022;51(4):297-309.
  • [25] Omur A, Kirbas A, Aksu E, Kandemir FM, Dorman E, Kaynar O, et al. Effects of antioxidant vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) on some metabolic and reproductive profiles in dairy cows during transition period. Polish journal of veterinary sciences. 2016.
  • [26] Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clinical chemistry. 1988;34(3):497-500.
  • [27] Aebi H. Catalase. Methods of enzymatic analysis. Elsevier; 1974. p. 673-84.
  • [28] Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochemical and biophysical research communications. 1976;71(4):952-8.
  • [29] Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical biochemistry. 1968;25:192-205.
  • [30] Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clinica chimica acta. 1991;196(2-3):143-51.
  • [31] Türk G, Ateşşahin A, Sönmez M, Çeribaşi AO, Yüce A. Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertility and sterility. 2008;89(5):1474-81.
  • [32] Aksu EH, Akman O, Özkaraca M, Ömür A, Ucar Ö. Effect of Maclura pomifera extract on cisplatin-induced damages in reproductive system of male rats. Kafkas Univ Vet Fak Derg. 2015;21:397-403.
  • [33] Tuncer SÇ, Akarsu SA, Küçükler S, Gür C, Kandemir FM. Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue. Environmental toxicology. 2023.
  • [34] Bal R, Naziroğlu M, Türk G, Yilmaz Ö, Kuloğlu T, Etem E, et al. Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats. Cell biochemistry and function. 2012;30(6):492-9.
  • [35] Aksu E, Akman O, Ömür A, Karakuş E, Can I, Kandemir F, et al. 3, 3 diindolylmethane leads to apoptosis, decreases sperm quality, affects blood estradiol 17 β and testosterone, oestrogen (α and β) and androgen receptor levels in the reproductive system in male rats. Andrologia. 2016;48(10):1155-65.
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  • [37] Caglayan C, Demir Y, Kucukler S, Taslimi P, Kandemir FM, Gulçin İ. The effects of hesperidin on sodium arsenite‐induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. Journal of food biochemistry. 2019;43(2):e12720.
  • [38] Kandemir FM, Caglayan C, Darendelioğlu E, Küçükler S, İzol E, Kandemir Ö. Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation. Life Sciences. 2021;277:119610.
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  • [43] Aksu EH, Kandemir FM, Küçükler S. Ameliorative effect of hesperidin on streptozotocin‐diabetes mellitus‐induced testicular DNA damage and sperm quality degradation in Sprague–Dawley rats. Journal of Food Biochemistry. 2021;45(10):e13938.
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  • [46] El-Shenawy NS. Effects of insecticides fenitrothion, endosulfan and abamectin on antioxidant parameters of isolated rat hepatocytes. Toxicology in vitro. 2010;24(4):1148-57.
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Timokinonun sıçanlarda D-galaktoz ve alüminyum klorür kaynaklı testis fonksiyon bozukluğuna karşı etkileri.

Year 2023, , 99 - 104, 27.09.2023
https://doi.org/10.46810/tdfd.1291880

Abstract

Alzheimer hastalığı tüm dokularda olumsuz etkilemektedir. Bu çalışmada deneysel alzheimer hastalığı oluşturulan ratlarda testis toksisitesi üzerine TQ etkileri belirlenmesi amaçlanmıştır. Çalışmada ağırlıkları 190-230 gr arasında değişen 33 adet Wistar Albino cinsi rat kullanıldı. Sıçanlar, her grupta 11 sıçan olmak üzere kontrol, ALZ ve ALZ+TQ olarak 3 eşit gruba ayrıldı. Kontrol grubuna, 28 gün boyunca IP yoluyla serum fizyolojik günlük olarak verildi. ALZ grubuna 28 gün boyunca günlük olarak 60 mg/kg D-gal+40 mg/kg AlCl3 IP verildi. ALZ+TQ grubuna 28 gün 60 mg/kg D-gal +40mg/kg AlCl3 IP+20 mg/kg TQ son 14 gün oral sonda ile günlük olarak verildi. Çalışmamızın bulgularına göre ALZ grubunda SOD, CAT, GPx aktivitesi ve GSH düzeylerinde azalma, MDA düzeylerinde ise artış saptanmıştır. ALZ+TQ grubunda SOD, GPx, CAT aktiviteleri ve GSH seviyeleri artarken MDA seviyeleri azaldı. Sperma analizleri, ALZ grubunda sperm motilite ve sperm yoğunluğunda azalma, anormal sperm ve ölü canlı spermatozoa oranında artış olduğunu göstermiştir. ALZ+TQ tedavi grubunda sperm hareketliliği, anormal sperm oranı ve ölü sperm oranı düzeldi. Sonuç olarak, AlCl3+D-Gal'in neden olduğu semen kalitesindeki azalma ve oksidatif stres artışının TQ tarafından baskılandığı, testis dokusunu oksidatif hasardan koruduğu ve semen kalitesini arttırdığı belirlendi.

References

  • [1] Supnet C, Bezprozvanny I. Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell calcium. 2011;50(3):303-9.
  • [2] Zhang Y, Pi Z, Song F, Liu Z. Ginsenosides attenuate d-galactose-and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer's disease. Journal of ethnopharmacology. 2016;194:188-95.
  • [3] Ahmed SA, Mohammed WI. Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats. Biomedicine & Pharmacotherapy. 2021;139:111594.
  • [4] Exley C. Does antiperspirant use increase the risk of aluminium-related disease, including Alzheimer's disease? Molecular Medicine Today. 1998;4(3):107-9.
  • [5] Sood PK, Nahar U, Nehru B. Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain. Neurotoxicity research. 2011;20:351-61.
  • [6] Tahari FZ, Lablack M, Hamadouche NA, Tahari Z, Aoues A. Protective effect of Haloxylon salicornicum on hepatic and renal functions of Wistar rats exposed to aluminium. African Journal of Biotechnology. 2016;15(9):293-302.
  • [7] Klein J, Mold M, Mery L, Cottier M, Exley C. Aluminum content of human semen: Implications for semen quality. Reproductive Toxicology. 2014;50:43-8.
  • [8] Güvenç M, Cellat M, Gökçek İ, Arkalı G, Uyar A, Tekeli İO, et al. Tyrosol prevents AlCl3 induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway. Andrologia. 2020;52(2):e13499.
  • [9] Guo C-H, Huang C-J, Chen S-T, Hsu G-SW. Serum and testicular testosterone and nitric oxide products in aluminum-treated mice. Environmental toxicology and pharmacology. 2001;10(1-2):53-60.
  • [10] Türk E, Ozan Tekeli I, Özkan H, Uyar A, Cellat M, Kuzu M, et al. The protective effect of esculetin against aluminium chloride‐induced reproductive toxicity in rats. Andrologia. 2021;53(2):e13930.
  • [11] Huang C-C, Chiang W-D, Huang W-C, Huang C-Y, Hsu M-C, Lin W-T. Hepatoprotective effects of swimming exercise against D-galactose-induced senescence rat model. Evidence-Based Complementary and Alternative Medicine. 2013.
  • [12] Hakimizadeh E, Hassanshahi J, Kaeidi A, Nematollahi MH, Taghipour Z, Rahmani M, et al. Ceftriaxone improves hepatorenal damages in mice subjected to D-galactose-induced aging. Life Sciences. 2020;258:118-9.
  • [13] Mohamed NE-S, Abd El-Moneim AE. Ginkgo biloba extract alleviates oxidative stress and some neurotransmitters changes induced by aluminum chloride in rats. Nutrition. 2017;35:93-9.
  • [14] Gezici S, Koçum D. Nörodejeneratif Hastalıkların Tedavisinde Nöroprotektif Ajan Olarak Tıbbi Bitkiler ve Fitokimyasallar. Türk Doğa ve Fen Dergisi. 2021;10(2):325-37.
  • [15] Varisli B, Caglayan C, Kandemir F, Gür C, Bayav I, Genc A. The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6 /IRE1/ PERK/ GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats. Molecular Biology Reports. 2022;49(10).
  • [16] Gür C, Kandemir O, Kandemir FM. Investigation of the effects of hesperidin administration on abamectin‐induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, and JAK2/STAT3 pathways. Environmental Toxicology. 2022;37(3):401-12.
  • [17] Gür C, Kandemir FM, Genç A. Bortezomib ile kalp hasarı oluşturulan ratlarda berberinin oksidatif ve nitrozatif stres üzerine etkisi. Türk Doğa ve Fen Dergisi. 2020;9(2):118-26.
  • [18] Imran M, Rauf A, Khan IA, Shahbaz M, Qaisrani TB, Fatmawati S, et al. Thymoquinone: A novel strategy to combat cancer: A review. Biomedicine & Pharmacotherapy. 2018;106:390-402.
  • [19] Ahmad N, Ahmad R, Al-Layly A, Al-Shawi H, Al-Ali A, Amir M, et al. Ultra-high-performance liquid chromatography-based identification and quantification of thymoquinone in Nigella sativa extract from different geographical regions. Pharmacognosy Magazine. 2018;14.
  • [20] Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of pharmaceutical and biomedical analysis. 1999;19(5):757-62.
  • [21] Gökçe A, Oktar S, Koc A, Yonden Z. Protective effects of thymoquinone against methotrexate-induced testicular injury. Human & experimental toxicology. 2011;30(8):897-903.
  • [22] Gür FM, Timurkaan S, Taskin E, Guven C, Gur HE, Senturk M, et al. Thymoquinone improves testicular damage and sperm quality in experimentally varicocele‐induced adolescent rats. Andrologia. 2021;53(5):e14033.
  • [23] Hassan E, El-Neweshy M, Hassan M, Noreldin A. Thymoquinone attenuates testicular and spermotoxicity following subchronic lead exposure in male rats: Possible mechanisms are involved. Life sciences. 2019;230:132-40.
  • [24] Akarsu GD, Çetin A. The Effect of Thymoquinone on Oxidative Stress Parameters and Apolipoprotein E in Alzheimer Model in Rats. Dementia and Geriatric Cognitive Disorders. 2022;51(4):297-309.
  • [25] Omur A, Kirbas A, Aksu E, Kandemir FM, Dorman E, Kaynar O, et al. Effects of antioxidant vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) on some metabolic and reproductive profiles in dairy cows during transition period. Polish journal of veterinary sciences. 2016.
  • [26] Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clinical chemistry. 1988;34(3):497-500.
  • [27] Aebi H. Catalase. Methods of enzymatic analysis. Elsevier; 1974. p. 673-84.
  • [28] Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochemical and biophysical research communications. 1976;71(4):952-8.
  • [29] Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical biochemistry. 1968;25:192-205.
  • [30] Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clinica chimica acta. 1991;196(2-3):143-51.
  • [31] Türk G, Ateşşahin A, Sönmez M, Çeribaşi AO, Yüce A. Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertility and sterility. 2008;89(5):1474-81.
  • [32] Aksu EH, Akman O, Özkaraca M, Ömür A, Ucar Ö. Effect of Maclura pomifera extract on cisplatin-induced damages in reproductive system of male rats. Kafkas Univ Vet Fak Derg. 2015;21:397-403.
  • [33] Tuncer SÇ, Akarsu SA, Küçükler S, Gür C, Kandemir FM. Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue. Environmental toxicology. 2023.
  • [34] Bal R, Naziroğlu M, Türk G, Yilmaz Ö, Kuloğlu T, Etem E, et al. Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats. Cell biochemistry and function. 2012;30(6):492-9.
  • [35] Aksu E, Akman O, Ömür A, Karakuş E, Can I, Kandemir F, et al. 3, 3 diindolylmethane leads to apoptosis, decreases sperm quality, affects blood estradiol 17 β and testosterone, oestrogen (α and β) and androgen receptor levels in the reproductive system in male rats. Andrologia. 2016;48(10):1155-65.
  • [36] Akarsu SA, Türk G, Arkalı G, Çeribaşı AO, Yüce A. Changes in heavy metal levels, reproductive characteristics, oxidative stress markers and testicular apoptosis in rams raised around thermal power plant. Theriogenology. 2022;179:211-22.
  • [37] Caglayan C, Demir Y, Kucukler S, Taslimi P, Kandemir FM, Gulçin İ. The effects of hesperidin on sodium arsenite‐induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. Journal of food biochemistry. 2019;43(2):e12720.
  • [38] Kandemir FM, Caglayan C, Darendelioğlu E, Küçükler S, İzol E, Kandemir Ö. Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation. Life Sciences. 2021;277:119610.
  • [39] Li S, Han B, Wu P, Yang Q, Wang X, Li J, et al. Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis. Environmental Toxicology. 2022;37(1):69-78.
  • [40] PT Manfo F, A Nantia E, P Mathur P. Effect of environmental contaminants on mammalian testis. Current molecular pharmacology. 2014;7(2):119-35.
  • [41] Radmehr V, Ahangarpour A, Khorsandi L, Omidi M. Protective Effects of Myricitrin and Vitamin E on Nephropathy of Aging Mice Model Induced By D-Galactose. Duzce Medical Journal. 2021;23(3):270-5.
  • [42] Gülcin I. Antioxidant activity of food constituents: an overview. Archives of toxicology. 2012;86:345-91.
  • [43] Aksu EH, Kandemir FM, Küçükler S. Ameliorative effect of hesperidin on streptozotocin‐diabetes mellitus‐induced testicular DNA damage and sperm quality degradation in Sprague–Dawley rats. Journal of Food Biochemistry. 2021;45(10):e13938.
  • [44] Drasga RE, Einhorn LH, Williams SD, Patel DN, Stevens EE. Fertility after chemotherapy for testicular cancer. Journal of Clinical Oncology. 1983;1(3):179-83.
  • [45] Çağlayan C, Taslimi P, Demir Y, Küçükler S, Kandemir FM, Gulcin I. The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes. Journal of biochemical and molecular toxicology. 2019;33(10):e22381.
  • [46] El-Shenawy NS. Effects of insecticides fenitrothion, endosulfan and abamectin on antioxidant parameters of isolated rat hepatocytes. Toxicology in vitro. 2010;24(4):1148-57.
  • [47] Belhan S, Özkaraca M, Kandemir FM, Gülyüz F, Yildirim S, Ömür AD, et al. Effectiveness of hesperidin on methotrexate-induced testicular toxicity in rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2017;23(5).
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There are 56 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Articles
Authors

Serkan Ali Akarsu 0000-0003-4450-6540

Gökhan Doğukan Akarsu 0000-0002-6586-5748

Aysun Çetin 0000-0003-4959-7955

Early Pub Date September 27, 2023
Publication Date September 27, 2023
Published in Issue Year 2023

Cite

APA Akarsu, S. A., Akarsu, G. D., & Çetin, A. (2023). Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats. Türk Doğa Ve Fen Dergisi, 12(3), 99-104. https://doi.org/10.46810/tdfd.1291880
AMA Akarsu SA, Akarsu GD, Çetin A. Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats. TDFD. September 2023;12(3):99-104. doi:10.46810/tdfd.1291880
Chicago Akarsu, Serkan Ali, Gökhan Doğukan Akarsu, and Aysun Çetin. “Effects of Thymoquinone Against D- Galactose and Aluminum Chloride Induced Testicular Dysfunction in Rats”. Türk Doğa Ve Fen Dergisi 12, no. 3 (September 2023): 99-104. https://doi.org/10.46810/tdfd.1291880.
EndNote Akarsu SA, Akarsu GD, Çetin A (September 1, 2023) Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats. Türk Doğa ve Fen Dergisi 12 3 99–104.
IEEE S. A. Akarsu, G. D. Akarsu, and A. Çetin, “Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats”., TDFD, vol. 12, no. 3, pp. 99–104, 2023, doi: 10.46810/tdfd.1291880.
ISNAD Akarsu, Serkan Ali et al. “Effects of Thymoquinone Against D- Galactose and Aluminum Chloride Induced Testicular Dysfunction in Rats”. Türk Doğa ve Fen Dergisi 12/3 (September 2023), 99-104. https://doi.org/10.46810/tdfd.1291880.
JAMA Akarsu SA, Akarsu GD, Çetin A. Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats. TDFD. 2023;12:99–104.
MLA Akarsu, Serkan Ali et al. “Effects of Thymoquinone Against D- Galactose and Aluminum Chloride Induced Testicular Dysfunction in Rats”. Türk Doğa Ve Fen Dergisi, vol. 12, no. 3, 2023, pp. 99-104, doi:10.46810/tdfd.1291880.
Vancouver Akarsu SA, Akarsu GD, Çetin A. Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats. TDFD. 2023;12(3):99-104.