Antibacterial effect of amoxicillin trihydrate and Cupresus sempervirens leaf extract on gram negative bacteria

Year 2024, , 43 - 48, 28.06.2024

Alican Bahadır Semerci Tuğba Ongun Sevindik

https://doi.org/10.46810/tdfd.1417900

Abstract

Difficulties in the treatment of infections caused by Gram-negative bacteria have led to studies in recent years directed towards improving the effectiveness of existing antibacterial agents. In our study, the antibacterial activities of the combined use of Cupressus sempervirens leaf extract and amoxicillin trihydrate on Escherichia coli ATCC 8739, Escherichia coli ATCC 25922 Salmonella typhimurium ATCC 14028, Salmonella abony NCTC 6017 bacteria and 4 coliform bacteria isolated from Karaman wastewater facility were investigated using the disc diffusion method. It was determined that the mixture of amoxicillin trihydrate and C. sempervirens leaf extract caused a synergistic effect on S. typhmurium and E. coli ATCC 8739. In general, it was observed that C. sempervirens leaf extracts contributed to the existing antibacterial activity of the antibiotic amoxicillin trihydrate. In addition, three of the bacteria isolated from wastewater were found to be sensitive to the antibiotic amoxicillin trihydrate, while one was found to be resistant.

Keywords

antibacterial activity, coliform bacteria, synergistic effect, wastewater

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