Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması

Sebahattin Karabulut; Ahmet Şevki Taşkıran

doi:10.46810/tdfd.761990

Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması

Abstract

Öz: Bu çalışmanın amacı, Ursodeksikolik asit (UDKA) ön tedavisinin PTZ ile indüklenen akut epilepsi fare modelinde nöbet davranışına ve hipokampal total oksidan status (TOS) ve kaspaz-3 ekpresyonlarına etkisini araştırmaktır. Çalışmada BALB-c türü 24 hayvan rastgele 4 gruba ayrıldı: Kontrol grubu, PTZ; PTZ ile nöbet indüklenen grup, UDKA-100; 5 gün boyunca UDKA 100 mg kg-1 verilen ve PTZ uygulanan grup, UDKA-200; 5 gün boyunca UDKA 200 mg kg-1 verilen ve PTZ uygulanan grup. UDKA ön tedavisinin nöbet davranışı üzerine istatistiksel olarak anlamlı bir etkisi bulunmadı. UDKA-200 grubunda daha belirgin olmak üzere, UDKA ön tedavisi hipokampal TOS ekspresyonunu anlamlı olarak azalttı. Benzer şekilde, hipokampal kaspaz-3 ekspresyonu UDKA alan gruplarda daha düşük bulundu. Sonuç olarak, UDKA antioksidatif ve antiapoptotik özellikleriyle epilepsi tedavisi için faydalı bir terapotik ajan olabilir.

Keywords

Supporting Institution

Herhangi bir kurumdan destek alınmamıştır.

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Sebahattin Karabulut ^*
0000-0002-3261-4125
Türkiye

Ahmet Şevki Taşkıran
0000-0002-5810-8415
Türkiye

Publication Date

December 30, 2020

Submission Date

July 1, 2020

Acceptance Date

December 18, 2020

Published in Issue

Year 2020 Volume: 9 Number: 2

DOI

https://doi.org/10.46810/tdfd.761990

IZ

https://izlik.org/JA54SK83ZJ

Cite

RIS / Bibtex

APA

Karabulut, S., & Taşkıran, A. Ş. (2020). Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması. Turkish Journal of Nature and Science, 9(2), 170-174. https://doi.org/10.46810/tdfd.761990

AMA

1.Karabulut S, Taşkıran AŞ. Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması. TJNS. 2020;9(2):170-174. doi:10.46810/tdfd.761990

Chicago

Karabulut, Sebahattin, and Ahmet Şevki Taşkıran. 2020. “Ursodeoksikolik Asit’in Farelerde Pentilentetrazol Ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması”. Turkish Journal of Nature and Science 9 (2): 170-74. https://doi.org/10.46810/tdfd.761990.

EndNote

Karabulut S, Taşkıran AŞ (December 1, 2020) Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması. Turkish Journal of Nature and Science 9 2 170–174.

IEEE

[1]S. Karabulut and A. Ş. Taşkıran, “Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması”, TJNS, vol. 9, no. 2, pp. 170–174, Dec. 2020, doi: 10.46810/tdfd.761990.

ISNAD

Karabulut, Sebahattin - Taşkıran, Ahmet Şevki. “Ursodeoksikolik Asit’in Farelerde Pentilentetrazol Ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması”. Turkish Journal of Nature and Science 9/2 (December 1, 2020): 170-174. https://doi.org/10.46810/tdfd.761990.

JAMA

1.Karabulut S, Taşkıran AŞ. Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması. TJNS. 2020;9:170–174.

MLA

Karabulut, Sebahattin, and Ahmet Şevki Taşkıran. “Ursodeoksikolik Asit’in Farelerde Pentilentetrazol Ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması”. Turkish Journal of Nature and Science, vol. 9, no. 2, Dec. 2020, pp. 170-4, doi:10.46810/tdfd.761990.

Vancouver

1.Sebahattin Karabulut, Ahmet Şevki Taşkıran. Ursodeoksikolik Asit’in Farelerde Pentilentetrazol ile Oluşturulan Akut Epileptik Nöbetler Üzerine Etkisinin Araştırılması. TJNS. 2020 Dec. 1;9(2):170-4. doi:10.46810/tdfd.761990