Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar

Kerim Emre Yanar; M. Sinan Aktaş

doi:10.46810/tdfd.814544

Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar

Abstract

Subklinik metabolik hastalıklar, klinik bulgu göstermeksizin, üreticilerde yüksek miktarda mali kayıplara veya optimalin altında üretime neden olan, metabolik süreçlerin bir veya daha fazlasına yönelik bozukluklardır. Daha çok periparturent (geçiş) dönemde sıklıkla görülen subklinik metabolik hastalıkların en yaygın olanları; subakut rumen asidozu, subklinik ketozis ve subklinik hipokalsemidir. Prevalansı ve insidansı dünya genelinde oldukça yüksek olan bu hastalıkların hem kendileri, hem de yatkınlığı artırdığı diğer hastalıklar nedeniyle (metritis, abomazum deplasmanı, klinik ketozis, kistik ovaryum, laminitis ve ruminitis) ciddi anlamda ekonomik kayıplara neden olmaktadırlar. Bu derlemede subklinik metabolik hastalıkların etiyoloji ve patogenezi, prevelans ve seroprevalansları, periparturient dönem hastalıklarıyla ilişkili tanı yöntemleri, subklinik hastalıkların takip prosedürleri ve korunma yolları hakkında detaylı bilgi verilmesi amaçlanmıştır.

Keywords

References

Fleischer P, Metzner M, Beyerbach M, Hoedemaker M, Klee W. The relationship between milk yield and the incidence of some diseases in dairy cows. J. Dairy Sci. 2001:84(9):2025-35.
Pryce J, Gaddis KP, Koeck A, Bastin C, Abdelsayed M, Gengler N, et al. Invited review: Opportunities for genetic improvement of metabolic diseases. J. Dairy Sci. 2016:99(9):6855-73.
Kleen J, Cannizzo C. Incidence, prevalence and impact of SARA in dairy herds. Anim. Feed Sci. Tech. 2012:172(1-2):4-8.
Duffield TF. Minimizing subclinical metabolic diseases in dairy cows. Adv. Dairy Technol. 2006:18:43-55.
Mostert P, Bokkers E, Van Middelaar C, Hogeveen H, De Boer I. Estimating the economic impact of subclinical ketosis in dairy cattle using a dynamic stochastic simulation model. Anim.: an international journal of animal bioscience. 2018:12(1):145.
McArt J, Nydam D, Overton M. Hyperketonemia in early lactation dairy cattle: A deterministic estimate of component and total cost per case. J. Dairy Sci. 2015;98(3):2043-54.
Enemark JM. The monitoring, prevention and treatment of sub-acute ruminal acidosis (SARA): A review. Vet. J. 2008:176(1):32-43.
Liang D, Arnold L, Stowe C, Harmon R, Bewley J. Estimating US dairy clinical disease costs with a stochastic simulation model. J. Dairy Sci. 2017:100(2):1472-86.

Avci C, Kızıl Ö. Geçiş Dönemindeki İneklerde Stres Parametreleri Üzerine Mineral Uygulamasının Etkileri. F. Ü. Sağ. Bil. Vet. Derg. 2012:26(2):87-91.
Sundrum A. Metabolic disorders in the transition period indicate that the dairy cows’ ability to adapt is overstressed. Anim. 2015:5(4):978-1020.
Esposito G, Irons PC, Webb EC, Chapwanya A. Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows. Anim. Reprod. Sci. 2014:144(3-4):60-71.
Nigussie T. A Review on the Role of Energy Balance on Reproduction of Dairy Cow. J. Dairy Res. Tech. 2018:1(003).
Atalay H. Milk Fat/Protein Ratio in Ketosis and Acidosis. BAUN Sağ Bil Derg. 8(3):143-6.
White HM. The role of TCA cycle anaplerosis in ketosis and fatty liver in periparturient dairy cows. Anim. 2015:5(3):793-802.
Fiorentin EL, Zanovello S, Gato A, Piovezan AL, Alves MV, Rocha RX, et al. Occurrence of subclinical metabolic disorders in dairy cows from western Santa Catarina state, Brazil. Pesq. Vet. Bras. 2018:38(4):629-34.
Gül Y. Latent asidotik stres. F. Ü. Sağ. Bil. Vet. Derg. 2010:24(1):51-55.
Mutsvangwa T, Wright T. Subacute ruminal acidosis (SARA) in dairy cows. Ministry of Agriculture and Rural Affairs: 2003.
Plaizier J, Krause D, Gozho G, McBride B. Subacute ruminal acidosis in dairy cows: the physiological causes, incidence and consequences. Vet. J. 2008:176(1):21-31.
Allen MS. Effects of diet on short-term regulation of feed intake by lactating dairy cattle. J. Dairy Sci. 2000:83(7):1598-624.
Hook SE, Steele MA, Northwood KS, Dijkstra J, France J, Wright A-DG, et al. Impact of subacute ruminal acidosis (SARA) adaptation and recovery on the density and diversity of bacteria in the rumen of dairy cows. FEMS Microbiol. Ecol. 011:78(2):275-84.
Jaramillo-López E, Itza-Ortiz MF, Peraza-Mercado G, Carrera-Chávez JM. Ruminal acidosis: strategies for its control. AUSTRAL J Vet. Sci. 2017:49(3):139-48.
Smith B. Large animal internal medicine, 3rd edn, Mosby. ISBN: 0-323-00946-B. 2002.
George L, Smith B. Peripheral nerve disorders. LAIM, ed. 2009:3:1169-73.
Serbester U, Çinar M, Hayırlı A. Sütçü ineklerde negatif enerji dengesi ve metabolik indikatörleri. Kafkas Univ. Vet. Fak. Derg. 2012:18(4):705-11.
Batmaz H. Sığırların İç Hastalıkları, Semptomdan Tanıya, Tanıdan Sağaltıma. VETAR Bursa Ltd Şti Nilüfer, Bursa. 2010.
Kominiarek MA, Rajan P. Nutrition recommendations in pregnancy and lactation. Med. Clin. North Am. 2016:100(6):1199-215.
Ortega Cerrilla ME, Mendoza Martínez G. Starch digestion and glucose metabolism in the ruminant: A review. Interciencia. 2003:28(7):380-6.
Herdt TH. Ruminant adaptation to negative energy balance: Influences on the etiology of ketosis and fatty liver. Vet. Clin. North Am. Food Anim. 2000:16(2):215-30.
Duffield T. Subclinical ketosis in lactating dairy cattle. Vet. Clin. North Am. Food Anim. Pract. 2000:16(2):231-53.
Fedota O, Babalian V, Mitiohlo L, Mazniakov S, Valilshchikov M, Tyzhnenko T, et al. Bone mineral density in evaluation the productive traits and reproductive health of dairy cows. J. Vet. Med. Biotech. Biosafety. 2017:3(4):16-22.
Goff JP, Liesegang A, Horst R. Diet-induced pseudohypoparathyroidism: A hypocalcemia and milk fever risk factor. J. Dairy Sci. 2014:97(3):1520-8.
Goff JP. The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet. J. 2008:176(1):50-7.
Goff JP. Macromineral physiology and application to the feeding of the dairy cow for prevention of milk fever and other periparturient mineral disorders. Anim. Feed Sci. Technol. 2006:126(3-4):237-57.
Nasr MY, Elkhodary SA, Beder NA, Elshafey BG. Epidemiological and Diagnostic Studies on Subacute Ruminal Acidosis in Dairy Cows. Alex. J. Vet. Sci. 2017:53(2).
Stefańska B, Nowak W, Komisarek J, Taciak M, Barszcz M, Skomiał J. Prevalence and consequence of subacute ruminal acidosis in Polish dairy herds. J. Anim. Physiol. Anim. Nutr. (Berl) 2017:101(4):694-702.
Tajik J, Nadalian M, Raoufi A, Mohammadi GR, Bahonar AR. Prevalence of subacute ruminal acidosis in some dairy herds of Khorasan Razavi province, northeast of Iran. Iran. J. Vet. Res. 2009.10(1):28-32.
Vallejo-Timarán D, Reyes-Vélez J, VanLeeuwen J, Maldonado-Estrada J, Astaiza-Martínez J. Incidence and effects of subacute ruminal acidosis and subclinical ketosis with respect to postpartum anestrus in grazing dairy cows. Heliyon. 2020:6(4):e03712.
Garrett E, Nordlund K, Goodger W, Oetzel G. A cross-sectional field study investigating the effect of periparturient dietary management on ruminal pH in early lactation dairy cows. J. Dairy Sci. 1997:80(Suppl 1):169.
Kleen J, Hooijer G, Rehage J, Noordhuizen J. Rumenocentesis (rumen puncture): a viable instrument in herd health diagnosis. Dtw. Dtsch. Tierarztl. Wochenschr. 2004:111(12):458-62.
Kerem U, Örtlek O. Aydın İlinde Bazı Sütçü Sığır İşletmelerinde Subakut Ruminal Asidozis İnsidansının Belirlenmesi. MAE Vet. Fak. Derg. 2(1):25-39.
Daros RR, Hötzel MJ, Bran JA, LeBlanc SJ, von Keyserlingk MA. Prevalence and risk factors for transition period diseases in grazing dairy cows in Brazil. Prev. Vet. Med. 2017:145:16-22.
Garzón Audor AM, Oliver Espinosa OJ. Incidence and prevalence of clinical and subclinical ketosis in grazing dairy cattle in the Cundiboyacencian Andean plateau, Colombia. CES med. vet. zootec. 2018:13(2):121-36.
Duffield T, Lissemore K, McBride B, Leslie K. Impact of hyperketonemia in early lactation dairy cows on health and production. J. Dairy Sci. 2009:92(2):571-80.
McArt J, Nydam D, Ospina P, Oetzel G. A field trial on the effect of propylene glycol on milk yield and resolution of ketosis in fresh cows diagnosed with subclinical ketosis. J. Dairy Sci. 2011:94(12):6011-20.
McArt J, Nydam D, Oetzel G. Epidemiology of subclinical ketosis in early lactation dairy cattle. J. Dairy Sci. 2012:95(9):5056-66.
Dohoo IR, Martin S. Subclinical ketosis: prevalence and associations with production and disease. Comp. Med. 1984:48(1):1.
Reinhardt TA, Lippolis JD, McCluskey BJ, Goff JP, Horst RL. Prevalence of subclinical hypocalcemia in dairy herds. Vet. J. 2011:188(1):122-4.
Kimura K, Reinhardt T, Goff J. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J. Dairy Sci. 2006:89(7):2588-95.
Stone W. Nutritional approaches to minimize subacute ruminal acidosis and laminitis in dairy cattle. J. Dairy Sci. 2004:87:E13-E26.
Enemark JMD, Jorgensen R, Enemark PS. Rumen acidosis with special emphasis on diagnostic aspects of subclinical rumen acidosis: a review. Vet. ir Zootech. 2002:20(42):16-29.
Zhao C, Liu G, Li X, Guan Y, Wang Y, Yuan X, et al. Inflammatory mechanism of rumenitis in dairy cows with subacute ruminal acidosis. BMC Vet. Res. 2018:14(1):135.
Whitaker D, Smith E, Da Rosa G, Kelly J. Some effects of nutrition and management on the fertility of dairy cattle. Vet. Rec. 1993:133(3):61-4.
Uyarlar C, Çetingül S, Gültepe EE, Sial AR, Bayram İ. Effects of Subclinical and Clinical Ketosis on The Incidence of Mastitis, Metritis, Culling Rate and Some Hematological Parameters in Dairy Cows. Kocatepe Vet. J. 2018:11(2):186-93.
Chapinal N, Carson M, Duffield T, Capel M, Godden S, Overton M, et al. The association of serum metabolites with clinical disease during the transition period. J. Dairy Sci. 2011:94(10):4897-903.
LeBlanc S, Leslie K, Duffield T. Metabolic predictors of displaced abomasum in dairy cattle. J. Dairy Sci. 2005:88(1):159-70.
Martinez N, Risco C, Lima F, Bisinotto R, Greco L, Ribeiro E, et al. Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. J. Dairy Sci. 2012:95(12):7158-72.
Ducusin R, Uzuka Y, Satoh E, Otani M, Nishimura M, Tanabe S, et al. Effects of extracellular Ca2+ on phagocytosis and intracellular Ca2+ concentrations in polymorphonuclear leukocytes of postpartum dairy cows. Res. Vet. Sci. 2003:75(1):27-32.
Chapinal N, Carson M, LeBlanc S, Leslie K, Godden S, Capel M, et al. The association of serum metabolites in the transition period with milk production and early-lactation reproductive performance. J. Dairy Sci. 2012:95(3):1301-9.
Enemark JMD, Jørgensen RJ, Kristensen NB. An evaluation of parameters for the detection of subclinical rumen acidosis in dairy herds. Vet. Res. Commun. 2004:28(8):687-709.
Duffield T, Plaizier J, Fairfield A, Bagg R, Vessie G, Dick P, et al. Comparison of techniques for measurement of rumen pH in lactating dairy cows. J. Dairy Sci. 2004:87(1):59-66.
AlZahal O, Kebreab E, France J, Froetschel M, McBride B. Ruminal temperature may aid in the detection of subacute ruminal acidosis. J. Dairy Sci. 2008:91(1):202-7.
Brown M, Krehbiel C, Galyean M, Remmenga M, Peters J, Hibbard B, et al. Evaluation of models of acute and subacute acidosis on dry matter intake, ruminal fermentation, blood chemistry, and endocrine profiles of beef steers. J. Anim. Sci. 2000:78(12):3155-68.
Ruegg PL. Investigation of mastitis problems on farms. Vet. Clin. North Am. Food Anim. Pract. 2003:19(1):47-73.
Lachmann G, Siebert H. Bestimmung des Saure-Basen-Status in den Erythrozyten und im Lebergewebe beim Rind. Mh. Vet.-Med. 1980.
Gianesella M, Morgante M, Cannizzo C, Stefani A, Dalvit P, Messina V, et al. Subacute ruminal acidosis and evaluation of blood gas analysis in dairy cow. Vet. Med. Int. 2010:2010.
Atkinson O. Prevalence of subacute ruminal acidosis (SARA) on UK dairy farms. Cattle Pract. 2014:22(1):1-9.
Townsend J, editor Cowside tests for monitoring metabolic disease. Tri-State Dairy Nutrition Conference: 2011.
Samiei A, Liang J, Ghorbani G, Hirooka H, Yaakub H, Tabatabaei M. An evaluation of [Beta]-hydroxybutyrate in milk and blood for prediction of subclinical ketosis in dairy cows. Pol. J. Vet. Sci. 2010:13(2):349.
Mahrt A, Burfeind O, Voigtsberger R, Müller A, Heuwieser W. Evaluation of a new electronic handheld meter for measurement of β-hydroxybutyric acid in dairy cows. Tierarztl Prax. Ausg. G. Grosstiere Nutztiere 2014:42(1):5-10.
Voyvoda H, Erdogan H. Use of a hand-held meter for detecting subclinical ketosis in dairy cows. Res. Vet. Sci. 2010:89(3):344-51.
Weng X, Zhao W, Neethirajan S, Duffield T. Microfluidic biosensor for β-Hydroxybutyrate (βHBA) determination of subclinical ketosis diagnosis. J. Nanobiotechnology. 2015:13(1):13.
Huzzey J, Duffield T, LeBlanc S, Veira D, Weary D, Von Keyserlingk M. Haptoglobin as an early indicator of metritis. J. Dairy Sci. 2009:92(2):621-5.
Goldhawk C, Chapinal N, Veira D, Weary D, Von Keyserlingk M. Prepartum feeding behavior is an early indicator of subclinical ketosis. J. Dairy Sci. 2009:92(10):4971-7.
Gül Y. Geviş Getiren Hayvanların İç Hastalıkları (Sığır, Koyun-Keçi). II. Baskı Medipres Matbaacılık Ltd Şti, Malatya. 2006:452-4.
Alaçam E. Evcil hayvanlarda doğum ve infertilite. Medisan Yayınları, Ankara. 1997.
Hendriks S, Huzzey J, Kuhn-Sherlock B, Turner S-A, Mueller K, Phyn C, et al. Associations between lying behavior and activity and hypocalcemia in grazing dairy cows during the transition period. J. Dairy Sci. 2020.
Barraclough R, Shaw D, Thorup V, Haskell M, Lee W, Macrae A. The behavior of dairy cattle in the transition period: Effects of blood calcium status. J. Dairy Sci. 2020.
Venjakob P, Borchardt S, Thiele G, Heuwieser W. Evaluation of ear skin temperature as a cow-side test to predict postpartum calcium status in dairy cows. J. Dairy Sci. 2016:99(8):6542-9.
LeBlanc S. Monitoring metabolic health of dairy cattle in the transition period. J. Reprod. Dev. 2010:56(S):S29-S35.
Seifi HA, LeBlanc SJ, Leslie KE, Duffield TF. Metabolic predictors of post-partum disease and culling risk in dairy cattle. Vet J. 2011:188(2):216-20.
Walsh R, Walton J, Kelton D, LeBlanc S, Leslie K, Duffield T. The effect of subclinical ketosis in early lactation on reproductive performance of postpartum dairy cows. J. Dairy Sci. 2007:90(6):2788-96.
Duffield T, LeBlanc S, Bagg R, Leslie K, Ten Hag J, Dick P. Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. J. Dairy Sci. 2003:86(4):1171-6.
Quiroz-Rocha GF, LeBlanc S, Duffield T, Wood D, Leslie KE, Jacobs RM. Evaluation of prepartum serum cholesterol and fatty acids concentrations as predictors of postpartum retention of the placenta in dairy cows. J. Am. Vet. Med. A. 2009:234(6):790-3.
KENNERMAN E. Süt Sığırlarında Metabolik Profil Test. Turkiye Klinikleri J. Vet. Sci. 2011:2(2):96-101.
Weaver DM, Tyler JW, VanMetre DC, Hostetler DE, Barrington GM. Passive transfer of colostral immunoglobulins in calves. J. Vet. Intern. Med.2000:14(6):569-77.
Godden SM, Kelton D, Lissemore K, Walton J, Leslie K, Lumsden J. Milk urea testing as a tool to monitor reproductive performance in Ontario dairy herds. J. Dairy Sci. 2001:84(6):1397-406.
Kleen J, Hooijer G, Rehage J, Noordhuizen J. Subacute ruminal acidosis (SARA): a review. J. Vet. Med. A. 2003:50(8):406-14.
Souissi W, Bouraoui R. Relationship between Body Condition Score, Milk Yield, Reproduction, and Biochemical Parameters in Dairy Cows. Lactation in Farm Animals-Biology, Physiological Basis, Nutritional Requirements, and Modelization: IntechOpen: 2019.
Duffield T, Sandals D, Leslie K, Lissemore K, McBride B, Lumsden J, et al. Efficacy of monensin for the prevention of subclinical ketosis in lactating dairy cows. J. Dairy Sci. 1998:81(11):2866-73.
Thilsing T, Jørgensen RJ, Poulsen HD. In vitro binding capacity of zeolite A to calcium, phosphorus and magnesium in rumen fluid as influenced by changes in pH. J. Vet. Med. A. 2006:53(2):57-64.
Niu M, Ying Y, Bartell P, Harvatine K. The effects of feeding rations that differ in fiber and fermentable starch within a day on milk production and the daily rhythm of feed intake and plasma hormones and metabolites in dairy cows. J. Dairy Sci. 2017:100(1):187-98.
Roche J, Heiser A, Crookenden M, Burke C, Turner S, Kuhn-Sherlock B, et al. The effect of feeding synthetic zeolite A prepartum on indices of mineral and metabolic status, milk production and reproduction in grazing dairy cows. J. Dairy Sci. 2018:101:175.
Kerwin A, Ryan C, Leno B, Jakobsen M, Theilgaard P, Barbano D, et al. Effects of feeding synthetic zeolite A during the prepartum period on serum mineral concentration, oxidant status, and performance of multiparous Holstein cows. J. Dairy Sci. 2019:102(6):5191-207.
Lean I, Santos J, Block E, Golder H. Effects of prepartum dietary cation-anion difference intake on production and health of dairy cows: A meta-analysis. J. Dairy Sci. 2019:102(3):2103-33.
Santos J, Lean I, Golder H, Block E. Meta-analysis of the effects of prepartum dietary cation-anion difference on performance and health of dairy cows. J. Dairy Sci. 2019:102(3):2134-54.
Damir HA, Phillippo M, Thorp B, Milne J, Dick L, Inevison I. Effects of dietary acidity on calcium balance and mobilisation, bone morphology and 1, 25 dihydroxyvitamin D in prepartal dairy cows. Res. Vet. Sci. 1994:56(3):310-8.
Schonewille JT, Van't Klooster AT, Dirkzwager A, Beynen A. Stimulatory effect of an anion (chloride)-rich ration on apparent calcium absorption in dairy cows. Livest. Prod. Sci. 1994:40(3):233-40.
Roche JR, Dalley DE, O'Mara FP. Effect of a metabolically created systemic acidosis on calcium homeostasis and the diurnal variation in urine pH in the non-lactating pregnant dairy cow. J. Dairy Res. 2007:74(1):34-9.

Details

Primary Language

Turkish

Subjects

Veterinary Surgery

Journal Section

Review

Authors

Kerim Emre Yanar ^*
0000-0001-7302-7077
Türkiye

M. Sinan Aktaş
0000-0002-7206-5757
Türkiye

Publication Date

June 25, 2021

Submission Date

October 22, 2020

Acceptance Date

February 8, 2021

Published in Issue

Year 2021 Volume: 10 Number: 1

DOI

https://doi.org/10.46810/tdfd.814544

IZ

https://izlik.org/JA48MJ25ZT

Cite

RIS / Bibtex

APA

Yanar, K. E., & Aktaş, M. S. (2021). Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar. Türk Doğa Ve Fen Dergisi, 10(1), 304-315. https://doi.org/10.46810/tdfd.814544

AMA

1.Yanar KE, Aktaş MS. Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar. TJNS. 2021;10(1):304-315. doi:10.46810/tdfd.814544

Chicago

Yanar, Kerim Emre, and M. Sinan Aktaş. 2021. “Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar”. Türk Doğa Ve Fen Dergisi 10 (1): 304-15. https://doi.org/10.46810/tdfd.814544.

EndNote

Yanar KE, Aktaş MS (June 1, 2021) Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar. Türk Doğa ve Fen Dergisi 10 1 304–315.

IEEE

[1]K. E. Yanar and M. S. Aktaş, “Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar”, TJNS, vol. 10, no. 1, pp. 304–315, June 2021, doi: 10.46810/tdfd.814544.

ISNAD

Yanar, Kerim Emre - Aktaş, M. Sinan. “Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar”. Türk Doğa ve Fen Dergisi 10/1 (June 1, 2021): 304-315. https://doi.org/10.46810/tdfd.814544.

JAMA

1.Yanar KE, Aktaş MS. Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar. TJNS. 2021;10:304–315.

MLA

Yanar, Kerim Emre, and M. Sinan Aktaş. “Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar”. Türk Doğa Ve Fen Dergisi, vol. 10, no. 1, June 2021, pp. 304-15, doi:10.46810/tdfd.814544.

Vancouver

1.Kerim Emre Yanar, M. Sinan Aktaş. Periparturient Dönemde Süt Sığırlarında Sıklıkla Görülen Subklinik Metabolik Hastalıklara Güncel Yaklaşımlar. TJNS. 2021 Jun. 1;10(1):304-15. doi:10.46810/tdfd.814544

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https://doi.org/10.38137/vftd.1177485