Kanser Dostu MEIS Proteinleri

Abstract

Miyeloid kanser türünden ismini alan MEIS; enerji üretimini teşvik eden, ROS seviyelerini minimum düzeye indirmeye çalışan, kalp kası gelişim evresinde görev alan bir proteindir. Kanserli hücreler MEIS proteini metastaz için kullanmaktadır. MEIS proteini kanserli hücrelerde durdurmak amacıyla ‘kanseri kendi silahıyla vurma’ olarak tanımlanan MEIS protein inhibitörleri (MEISi) Türk akademisyen Fatih KOCABAŞ tarafından keşfedilmiş ve bu çalışma Uluslararası Hemotoloji-Onkoloji ödülüne layık görülmüştür. Yapılan çalışmada MEIS protein inhibitörleri meme ve pankreas gibi kanser türlerinden, %75 ve %95 gibi ciddi oranda kanserli hücrelerin yayılımını engellediği belirtilmiştir. Bu derlemede MEIS proteinlerinin; kanser türleri ve hastalıklar üzerindeki etkisi, MEIS inhibitörlerinin (MEISi) keşfiyle ilgili bilgilerden bahsedilmektedir.

Keywords

• İnhibitör
• Kanser
• MeIs proteini
• Metastaz

Cancer Friendly MEIS Proteins

Abstract

MEIS, named after the type of myeloid cancer; It is a protein that promotes energy production, tries to minimize ROS levels, and takes part in the development phase of the heart muscle. Cancerous cells use the MEIS protein for metastasis. In order to stop the MEIS protein in cancerous cells, MEIS protein inhibitors (MEISi), which are defined as 'shooting the cancer with its own weapon', have been discovered. It has been determined that MEIS protein inhibitors prevent the spread of cancerous cells, such as 75% and 95%, from cancer types such as chest and pancreas. In this review, MEIS proteins; Information about the effects on cancer types and diseases, the discovery of MEIS inhibitors (MEISi), the importance of MEIS protein inhibitors in cancer treatment are mentioned.

Keywords

• Cancer
• Inhibitor
• MEIS proteins
• Metastasis

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