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Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs

Year 2024, Issue: 1, 69 - 72, 01.10.2024
https://doi.org/10.46810/tdfd.1411970

Abstract

Statins work as inhibitors of the HMG-CoA reductase enzyme and are the most commonly prescribed cholesterol-lowering drug group for people with cardiovascular disease or risk. This study aimed to determine the pharmacokinetic parameters and toxicities of conventional and new-generation cholesterol drugs such as atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin, rosuvastatin and pitavastatin. Absorption, distribution, metabolism, and excretion (ADME) parameters and toxicity predictions of drugs were made using in silico modeling, which gives faster results than animal experiments and does not involve any laboratory costs. In calculations made using structural similarity, compounds' pharmacokinetic properties and toxicity predictions are obtained based on previously known structure-activity data. The study results showed that the toxicity classifications of the drugs were 5 (LD: 5000 mg/kg) for atorvastatin and 6 (LD: 8939 mg/kg) for pravastatin, respectively. The toxicity classes were found to be 4 for all the other statin group drugs. The results showed that pravastatin had the lowest toxicity among investigated cholesterol drugs, while pitavastatin and fluvastatin had the highest toxic effects. Accordingly, it is recommended that the consequences of using pravastatin and atorvastatin, cholesterol drugs with lower toxicity classes, should be investigated more seriously in terms of minimum toxic substance intake for patient groups requiring high doses of medication.

Ethical Statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Thanks

This study was presented as an oral presentation at the "6th International Conference on Life and Engineering Sciences (ICOLES 2023)" conference.

References

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Year 2024, Issue: 1, 69 - 72, 01.10.2024
https://doi.org/10.46810/tdfd.1411970

Abstract

References

  • Civek S. ve Akman M. Dünyada ve Türkiye’de kardiyovasküler hastalıkların sıklığı ve riskin değerlendirilmesi. Jour Turk Fam Phy 2022; 13 (1): 21-28. Doi: 10.15511/tjtfp.22.00121.
  • Alenghat FJ, Davis AM (February 2019). "Management of Blood Cholesterol". JAMA. 321 (8): 800–801. doi:10.1001/jama.2019.0015. PMC 6679800.
  • National Clinical Guideline Centre (UK) (July 2014). Lipid Modification: Cardiovascular Risk Assessment and the Modification of Blood Lipids for the Primary and Secondary Prevention of Cardiovascular Disease. National Institute for Health and Clinical Excellence: Guidance. London: National Institute for Health and Care Excellence (UK). PMID 25340243. NICE Clinical Guidelines, No. 181 – via NIH National Library of Medicine.
  • Endo, A. A gift from nature: the birth of the statins. Nat Med 14, 1050–1052 (2008). https://doi.org/10.1038/nm1008-1050
  • Sweetman SC, ed. (2009). "Cardiovascular drugs". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. pp. 1155–1434.
  • MarvinSketch
  • PreADMET, https://preadmet.qsarhub.com/, (2022).
  • ProTox-II- Prediction of Toxicity of Chemicals, (2022).
  • Yong-Jin Wu, Heterocycles and Medicine, Progress in Heterocyclic Chemistry, 2012
  • https://www.stereoelectronics.org/webDD/DD_05.html
  • Furuya, Y., Sekine, Y., Kato, H., Miyazawa, Y., Koike, H., & Suzuki, K. (2016). Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins. Prostate international, 4(2), 56-60.
  • Alan Talevi, Pablo A. M. Quiroga, (2018). ADME Processes in Pharmaceutical Sciences.
  • Olson, R. E., & Christ, D. D. (1996). Plasma protein binding of drugs. In Annual reports in medicinal chemistry (Vol. 31, pp. 327-336). Academic Press.
  • Libralato, G., Annamaria, V. G., & Francesco, A. (2010). How toxic is toxic? A proposal for wastewater toxicity hazard assessment. Ecotoxicology and Environmental Safety, 73(7), 1602-1611.
  • DePass, L. R. (1989). Alternative approaches in median lethality (LD50) and acute toxicity testing. Toxicology letters, 49(2-3), 159-170./
There are 15 citations in total.

Details

Primary Language English
Subjects Atomic and Molecular Physics
Journal Section Articles
Authors

Mustafa Tuğfan Bilkan 0000-0002-0306-1509

Çiğdem Bilkan 0000-0002-3347-673X

Publication Date October 1, 2024
Submission Date December 29, 2023
Acceptance Date April 17, 2024
Published in Issue Year 2024 Issue: 1

Cite

APA Bilkan, M. T., & Bilkan, Ç. (2024). Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs. Türk Doğa Ve Fen Dergisi(1), 69-72. https://doi.org/10.46810/tdfd.1411970
AMA Bilkan MT, Bilkan Ç. Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs. TJNS. October 2024;(1):69-72. doi:10.46810/tdfd.1411970
Chicago Bilkan, Mustafa Tuğfan, and Çiğdem Bilkan. “Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs”. Türk Doğa Ve Fen Dergisi, no. 1 (October 2024): 69-72. https://doi.org/10.46810/tdfd.1411970.
EndNote Bilkan MT, Bilkan Ç (October 1, 2024) Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs. Türk Doğa ve Fen Dergisi 1 69–72.
IEEE M. T. Bilkan and Ç. Bilkan, “Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs”, TJNS, no. 1, pp. 69–72, October 2024, doi: 10.46810/tdfd.1411970.
ISNAD Bilkan, Mustafa Tuğfan - Bilkan, Çiğdem. “Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs”. Türk Doğa ve Fen Dergisi 1 (October 2024), 69-72. https://doi.org/10.46810/tdfd.1411970.
JAMA Bilkan MT, Bilkan Ç. Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs. TJNS. 2024;:69–72.
MLA Bilkan, Mustafa Tuğfan and Çiğdem Bilkan. “Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs”. Türk Doğa Ve Fen Dergisi, no. 1, 2024, pp. 69-72, doi:10.46810/tdfd.1411970.
Vancouver Bilkan MT, Bilkan Ç. Determination of Pharmacokinetic and Toxicological Parameters of Some Commonly Used Statin Group Drugs. TJNS. 2024(1):69-72.

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