Yüksek Tansiyonun Omurlar Arası Fibröz Kıkırdak Histolojisi Üzerinde Etkisi Var Mıdır?

Year 2025, Volume: 14 Issue: 1, 192 - 196, 26.03.2025

Erhan Şahin , Damla Gül Fındık , Özlem Türelik

https://doi.org/10.46810/tdfd.1639045

Abstract

Kıkırdak doku, çevresindeki bağ dokusunda bulunan damarlarla beslendiğinden onarımı çok zor bir dokudur. Bu nedenle kardiyovasküler hastalıklar öncelikle kıkırdak dokusunu etkiler. Bu çalışmada, yüksek tansiyonun discus intervertebralis üzerindeki olası etkileri histopatolojik ve histomorfometrik olarak incelenmiştir. 13 normotansif ve 13 hipertansif hastanın discus intervertebralis'i histopatolojik ve histomorfometrik olarak karşılaştırılmıştır. Hastaların demografik bilgileri hastanenin hasta kayıt sisteminden elde edilmiştir. Histopatolojik değerlendirme için hematoksilen-eozin boyalı kesitler kullanılmıştır. Histolojik kesitlerde, kondrosit ve lakün çapları, morfometrik ölçüm programı ile 10 farklı alanda 400x büyütmede ölçülmüştür. Normotansif ve hipertansif hastaların discus intervertebralis'i kondrosit sayısı ve lakün çapı açısından farklılık göstermemiştir. Hipertansif hastaların yaş ortalaması (61.69±13.55), normotansif hastaların yaş ortalamasından (42±8.84) yüksekti (p<0.05). Grupların cinsiyet oranı istatistiksel olarak fark göstermedi (p>0.05). Bu çalışmada lomber disektomi uygulanan normotansif ve hipertansif hastaların discus intervertebralis'inin histopatolojik ve histomorfometri (kondrosit sayısı ve lakuna çapı açısından) açıdan farklı olmadığı gösterildi.

Keywords

Fibröz kıkırdak, omurlar arası disk, Yüksek Tansiyon, Histopatoloji, Histomorfometri.

Does High Blood Pressure Have an Effect on Intervertebral Fibrocartilage Histology?

Abstract

Since the cartilage tissue is fed by the vessels in the surrounding connective tissue, it is a very difficult tissue to repair. Therefore, cardiovascular diseases primarily affect the cartilage tissue. In this study, the possible effects of high blood pressure on discus intervertebralis were examined histopathologically and histomorphometrically.
Discus intervertebralis of 13 normotensive and 13 hypertensive patients were compared histopathologically and histomorphometrically. Demographic information of the patients was obtained from the patient registration system of the hospital. Hematoxylin-eosin-stained slices were used for histopathological evaluation. In histological sections, chondrocytes and lacunae diameters were measured at 400x magnification in 10 different areas with a computer morphometric measurement program.
Discus intervertebralis of normotensive and hypertensive patients did not differ in terms of chondrocyte count and lacunae diameter. The mean age of hypertensive patients (61.69±13.55) was higher than the mean age of normotensive patients (42±8.84) (p<0.05). The gender ratio of the groups did not show a statistical difference (p>0.05).
In this study, it was shown that the discus intervertebralis of normotensive and hypertensive patients who underwent lumbar discectomy were not different in terms of histopathologically and histomorphometrically (in terms of chondrocyte number and lacuna diameter).

Keywords

Fibrocartilage, intervertebral disc, High Blood Pressure, Histopathology, Histomorphometry

References

• Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA, Urban JP. Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am. 2006;88(2):30-5.
• Roberts S, Evans H, Trivedi J, Menage J. Histology and pathology of the human intervertebral disc. J Bone Joint Surg Am. 2006;88(2):10-4.
• Eygi E, Balkaya AN, Gurbet A, Şahin Ş. Non-Opere Tek Mesafe Lomber Disk Herniasyonlarinda Transforaminal Epidural Steroid Enjeksiyonu Etkinliğinin Değerlendirilmesi. Kocatepe Tıp Dergisi. 2023;24(2):148-53.
• Khamidov O, Khodzhanov IY, Mamasoliev B, Mansurov DS, Davronov A, Rakhimov A. The role of vascular pathology in the development and progression of deforming osteoarthritis of the joints of the lower extremities (Literature review). Annals of RSCB. 2021;25(1):214-25.
• Kabalyk M, Kovalenko T, Nevzorova V, Sukhanova G. Effect of Arterial Hypertension and Hyperlipidemia on the Remodeling of Articular Cartilage and the Development of Osteoarthritis (Experimental Study). Adv Gerontol 2020;10(1):79-85.
• Mazurov V, Stolov S, Vorobyeva O, Dolgikh S, Martynov ІV, Pobyegai O. Cardiovascular problems in rheumatology. Medical academic journal. 2009;9(1):59-65.
• Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223-37.
• Bilge O, Doral MN, Atesok K, Atay OA, Donmez G, Turhan E, et al. The effects of the synovium on chondrocyte growth: an experimental study. Knee Surg Sports Traumatol Arthrosc. 2011;19(7):1214-23.
• Ashmeik W, Joseph GB, Nevitt MC, Lane NE, McCulloch CE, Link TM. Association of blood pressure with knee cartilage composition and structural knee abnormalities: data from the osteoarthritis initiative. Skeletal Radiol. 2020;49(9):1359-68.
• Wang Y, Meng T, Ruan G, Zheng S, Zhu J, Cen H, et al. Associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis. Rheumatology (Oxford). 2021;60(10):4748-54.
• Yeater TD, Griffith JL, Cruz CJ, Patterson FM, Aldrich JL, Allen KD. Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner. Arthritis Research & Therapy. 2023;25(1):1-13.
• Maurer E, Klinger C, Lorbeer R, Hefferman G, Schlett CL, Peters A, et al. Association between cardiovascular risk factors and degenerative disc disease of the thoracolumbar spine in the general population: results from the KORA MRI Study. Acta Radiol. 2022;63(6):750-9.
• Samartzis D, Bow C, Karppinen J, Luk KDK, Cheung BMY, Cheung KMC. Hypertension is Independently Associated with Lumbar Disc Degeneration: A Large-Scale Population-Based Study. Global Spine Journal. 2014;4(1).