Does High Blood Pressure Have an Effect on Intervertebral Fibrocartilage Histology?

Öz

Since the cartilage tissue is fed by the vessels in the surrounding connective tissue, it is a very difficult tissue to repair. Therefore, cardiovascular diseases primarily affect the cartilage tissue. In this study, the possible effects of high blood pressure on discus intervertebralis were examined histopathologically and histomorphometrically. Discus intervertebralis of 13 normotensive and 13 hypertensive patients were compared histopathologically and histomorphometrically. Demographic information of the patients was obtained from the patient registration system of the hospital. Hematoxylin-eosin-stained slices were used for histopathological evaluation. In histological sections, chondrocytes and lacunae diameters were measured at 400x magnification in 10 different areas with a computer morphometric measurement program. Discus intervertebralis of normotensive and hypertensive patients did not differ in terms of chondrocyte count and lacunae diameter. The mean age of hypertensive patients (61.69±13.55) was higher than the mean age of normotensive patients (42±8.84) (p<0.05). The gender ratio of the groups did not show a statistical difference (p>0.05). In this study, it was shown that the discus intervertebralis of normotensive and hypertensive patients who underwent lumbar discectomy were not different in terms of histopathologically and histomorphometrically (in terms of chondrocyte number and lacuna diameter).

Anahtar Kelimeler

• Fibrocartilage
• intervertebral disc
• High Blood Pressure
• Histopathology
• Histomorphometry

Yüksek Tansiyonun Omurlar Arası Fibröz Kıkırdak Histolojisi Üzerinde Etkisi Var Mıdır?

Öz

Kıkırdak doku, çevresindeki bağ dokusunda bulunan damarlarla beslendiğinden onarımı çok zor bir dokudur. Bu nedenle kardiyovasküler hastalıklar öncelikle kıkırdak dokusunu etkiler. Bu çalışmada, yüksek tansiyonun discus intervertebralis üzerindeki olası etkileri histopatolojik ve histomorfometrik olarak incelenmiştir. 13 normotansif ve 13 hipertansif hastanın discus intervertebralis'i histopatolojik ve histomorfometrik olarak karşılaştırılmıştır. Hastaların demografik bilgileri hastanenin hasta kayıt sisteminden elde edilmiştir. Histopatolojik değerlendirme için hematoksilen-eozin boyalı kesitler kullanılmıştır. Histolojik kesitlerde, kondrosit ve lakün çapları, morfometrik ölçüm programı ile 10 farklı alanda 400x büyütmede ölçülmüştür. Normotansif ve hipertansif hastaların discus intervertebralis'i kondrosit sayısı ve lakün çapı açısından farklılık göstermemiştir. Hipertansif hastaların yaş ortalaması (61.69±13.55), normotansif hastaların yaş ortalamasından (42±8.84) yüksekti (p<0.05). Grupların cinsiyet oranı istatistiksel olarak fark göstermedi (p>0.05). Bu çalışmada lomber disektomi uygulanan normotansif ve hipertansif hastaların discus intervertebralis'inin histopatolojik ve histomorfometri (kondrosit sayısı ve lakuna çapı açısından) açıdan farklı olmadığı gösterildi.

Anahtar Kelimeler

• Fibröz kıkırdak
• omurlar arası disk
• Yüksek Tansiyon
• Histopatoloji
• Histomorfometri.

Kaynakça

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