ELECTROSPINNING OF PVP/CARVACROL/LANOLIN COMPOSITE NANOFIBERS

Year 2023, , 302 - 309, 31.12.2023

Hülya Kesici Güler , Mustafa Geysoğlu , Funda Cengiz Çallıoğlu

https://doi.org/10.7216/teksmuh.1406047

Abstract

In this study, it was aimed to produce and characterize various concentrations of carvacrol and lanolin loaded PVP nanofibers via electrospinning. Various concentrations of carvacrol:lanolin were added to the PVP polymer solutions such as 2.5, 5, 7.5, 10, 12.5 and 15 wt %. Solution properties such as viscosity, conductivity, and surface tension were measured. In terms of characterization studies, SEM, FT-IR, TGA and DSC analysis were carried out. According to the results of the study, viscosity increased and conductivity decreased with carvacrol:lanolin concentration increasement. However, surface tension was not affected from carvacrol:lanolin concentration. Nanowebs quality improved with carvacrol:lanolin concentrations. Generally, nanofibers are quite fine, smooth, and uniform. FT-IR spectrums verified that PVP, carvacrol and lanolin exist in the structure of nanofibers chemically. DSC and TGA results demonstrated that the thermal stability of carvacrol and lanolin, which have poor thermal stability, was enhanced by incorporating them into the PVP nanofiber structures. Considering antibacterial properties of carvacrol and wound healing properties of lanolin, these composite nanofiber surfaces have a high potential for use in the biomedical field, especially as a wound dressing.

Keywords

Polyvinylpyrrolidone, carvacrol, lanolin, electrospinning, nanofiber.

Supporting Institution

Süleyman Demirel University Scientific Research Project Funding Unit

Project Number

FYL-2018-5824

Thanks

This research was supported by Süleyman Demirel University Scientific Research Project Funding Unit, Project No: Project No: FYL-2018-5824. The authors would like to thank Süleyman Demirel University Natural Products Application and Research Center for supplying carvacrol.

References

• 1. Bhardwaj, N., & Kundu, S. C. (2010). Electrospinning: a fascinating fiber fabrication technique. Biotechnology advances, 28(3), 325-347.
• 2. Haghi, A. K. (2011). Advances in nanofibre research. Smithers Rapra.
• 3. Altundag, S., Aslim, B., and Ozturk, S., (2011). In vitro antimicrobial activities of essential oils from origanum minutiflorum and sideritis erytrantha subsp. Erytrantha on phytopathogenic bacteria. J. Essent. Oil Res., 23, 4–8.
• 4. Erler, F. and Cetin, H. (2009). Components from the essential oils from two Origanum species as larvicides against Euproctis chrysorrhoea (Lepidoptera: Lymantriidae). Journal of Agricultural and Urban Entomology. 26, 31–41.
• 5. Paster, N., Menasherov, M., Ravid, U., & Juven, B. (1995). Antifungal activity of oregano and thyme essential oils applied as fumigants against fungi attacking stored grain. Journal of food protection, 58(1), 81-85.
• All references were included in the article file.