Production of Nanofibrous Wound Dressings Via Solution Blowing

Abstract

In this study, thermoplastic polyurethane (TPU) nanofibers were produced via a novel technique: solution blowing. Smoke tree oil was obtained with soxhlet extraction and according to GC-MS analysis; it was shown that obtained extract includes constituents with high antimicrobial activity. Therefore, TPU nanofibers coated with smoke tree oil at different amounts using drop casting in order to obtain antibacterial nanofibers. All coated nanofibers showed antibacterial activity against to S.Aureus and E.Coli. On the other hand, SEM images show that increase of amount of smoke tree oil effect to fiber morphology negatively. Thus, air permeability of nanofibers mats decreased significantly. 

Keywords

• Nanofiber,solution blowing,antibacterial activity,wound dressing

Antibakteriyel Nanolif Yapılarının Çözeltiden Üfleme Sistemi ile Üretimi ve Karakterizasyonu

Abstract

Bu çalışmada termoplastik poliüretan (TPU) nanolifler, yenilikçi bir yöntem olan çözeltiden üfleme ile üretilmiştir. Duman ağacı özütü, sokslet ekstraksiyonu ile elde edilmiş ve GC-MS analizine göre elde edilen özütün antimikrobiyal etkinliğe sahip bileşenleri içerdiği görülmüştür. Dolayısıyla TPU nanolifler, antibakteriyel etkinlik kazandırılmak için farklı miktarlarda (2-10 mg/cm2) duman ağacı özütü ile mikro döküm yöntemiyle kaplanmıştır. Kaplanan tüm numuneler difüzyon agar testinde S. Aureus ve E.Coli bakterilerine karşı etkinlik göstermişlerdir. Ancak, SEM görüntülerine göre artan duman ağacı özütü miktarının nanolif morfolojisini olumsuz etkilediği görülmüştür. Bunun sonucunda da nanolif yapılarının hava geçirgenlik değerleri düşmüştür. 

Keywords

• Nanolifler,çözeltiden üfleme,antibakteriyel etkinlik,yara örtüsü

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