Sıçan Aortik Endotelyumunun İnce Yapısı Üzerine Sigara Dumanının Etkisi

Öz

Bu çalışmada deney grubundaki farelere sigara dumanı-hava karışımı 1/9 oranında 60 gün boyunca günde ikisaat verildi. Kontrol sıçanlar ise oda havasına maruz bırakıldı. Sigara dumanına maruz bırakılan sıçanlarınendotelyum hücrelerinin apikal yüzeyinde microvillus benzeri yapıların meydana geldiği gözlenmiştir. Bu safhadahücreler poligonal bir yapıya dönüşmüşlerdir. Bununla beraber endotel hücrelerinin yüzeyinde küçük partiküllerinbiriktiği ve endositozun arttığı tespit edilmiştir. Subendotelyal tabakanın da düzensizleştiği gözlenmiştir

Anahtar Kelimeler

• Endotelyum, sigara dumanı, ultrastrüktür

Effects Of Cigarette Smoking On The Ultrastructure Of Rat Aortic Endothelium

Abstract

In this study, rats in experimental group were exposed to smoke-air mixture 1/9 volume two hours/day,consecutively 60 days. Control animals exposed to room air. It was observed at the 60thday that microvilli-likestructures formed on the apical surface of endothelium cells of the rats exposed to cigarette smoke. At this stage,cells had polygonal structure. However, it was established that small particles accumulated on the surface of theendothelium cells and endocytosis increased. It was also observed that subendothelial layer became irregular

Keywords

• Endothelium, cigarette smoke, ultrastructure

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