Sıçan Aortik Endotelyumunun İnce Yapısı Üzerine Sigara Dumanının Etkisi

Öz

Bu çalışmada deney grubundaki farelere sigara dumanı-hava karışımı 1/9 oranında 60 gün boyunca günde ikisaat verildi. Kontrol sıçanlar ise oda havasına maruz bırakıldı. Sigara dumanına maruz bırakılan sıçanlarınendotelyum hücrelerinin apikal yüzeyinde microvillus benzeri yapıların meydana geldiği gözlenmiştir. Bu safhadahücreler poligonal bir yapıya dönüşmüşlerdir. Bununla beraber endotel hücrelerinin yüzeyinde küçük partiküllerinbiriktiği ve endositozun arttığı tespit edilmiştir. Subendotelyal tabakanın da düzensizleştiği gözlenmiştir

Anahtar Kelimeler

• Endotelyum, sigara dumanı, ultrastrüktür

Effects Of Cigarette Smoking On The Ultrastructure Of Rat Aortic Endothelium

Abstract

In this study, rats in experimental group were exposed to smoke-air mixture 1/9 volume two hours/day,consecutively 60 days. Control animals exposed to room air. It was observed at the 60thday that microvilli-likestructures formed on the apical surface of endothelium cells of the rats exposed to cigarette smoke. At this stage,cells had polygonal structure. However, it was established that small particles accumulated on the surface of theendothelium cells and endocytosis increased. It was also observed that subendothelial layer became irregular

Keywords

• Endothelium, cigarette smoke, ultrastructure

Kaynakça

1. Murphy EA, Mustard JF. Tobacco and thrombosis. Am J Pub Health 1966; 56: 1061-1073.
2. Dawber TR, Kannel WB, Revotskie N, Stokes J, Kagan A, Gordon T. Some factors associated with the development of coronary heart disease: Six years follow-up experience in the Framingham study. Am J Pub Health. ; 49: 1349-1356.
3. Spain DM, Bradess VA. Sudden death from coronary heart disease: Survival time, frequency of thrombi and cigarette smoking. Chest 1970; 58: 107-110.
4. Strong JP, Richards ML. Cigarette smoking and atherosclerosis in autopsied men. Atherosclerosis. 1976; : 451-476.
5. Ross R Glomset JA. The pathogenesis of atherosclerosis. N. Eng. J. Med., 1976; 295: 420.
6. Report of the surgeon general smoking and Health, US Department of Health Education and Welfare, Cardiovascular Disease. 1979; pp 4-77.
7. Bazin M, Turcotte H, Lagace R, Boutet M. Effect cardiovasculiares de la fumee de cigarette chez le rat. Rev. Can. Biol. 1981; 40: 263-276.
8. Pittilo RM, Bull HA, Gulati S, Rowles PM, Blow CM , Machin SJ, Woolf N. Nicotine and cigarette smoking: Effects on the ultrastructure of aortic endothelium. Int J Exp Path 1990; 71: 573-586.

9. Assusmen I. Chromatin changes of endothelial cells in umbilical arteries in smokers. Clin Cardiol 1982; 5: 656.
10. Asmussen I. Ultrastructure of the umbilical arteries from new-born delivered at term by a mother who smoked cigarettes per day. Acta Path Scand 1982; 90: 397-404.
11. Boutet M, Bazin M, Turcotte H, Lagace R. Effects of cigarette smoke on rat thoracic aorta. Artery. 1980; : 56-72.
12. Booyse FM, Osikowicz G, Quarfoot AJ. Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium. Am J Pathol 1981; 2: 229-238.
13. Royal College of Physicians, Smoking and Health Now. A new report and summary on smoking and its effects on health. Pitman, London, 1971; pp 9-148.
14. Zimmerman M, McGeachie J. The effect of nicotine on aortic endothelium: A quantitative ultrastructural study. Atherosclerosis 1987; 63: 33-41.
15. Watanabe T, Hirata M. Atherosclerosis. Sogo Rinsho 1984; 33: 647-655.
16. Watanabe T, Tokunaga O, Fan J. Atherosclerosis and Macrophages. Acta Pathologica Japonica. 1989; (8): 473-486.
17. Yardımcı S, Atan A, Taştan H, Kalender Y, Kalender S, Sunguroğlu K, Avunduk MC. Effects of cigarette smoke exposure on spermatogenesis in rat. Journal of Ankara Medical School. 1996; 18 (4): 181-186.