Deneysel diyabetin karaciğer dokusunda oluşturduğu bazı değişiklikler üzerine çam yağının etkisi

Year 2014, Volume: 71 Issue: 3, 113 - 124, 01.09.2014

Ersin Demir Ökkeş Yılmaz

Abstract

Amaç: Bu çalışma; deneysel diyabet oluşturulan sıçanlarda çam yağının karaciğer dokusunda yağ asidi bileşimi, malondialdehit MDA , glutatyon GSH , total protein, ADEK vitaminleri, kolesterol ve bazı sterol parametreleri üzerinde etkisinin araştırılması için tasarlandı.Yöntem: Sıçanlar; kontrol K , streptozotosin STZ ve streptozotosin STZ + çam yağı ÇY olmak üzere üç grubu ayrıldı. STZ gruplarına intraperitoneal enjeksiyonla streptozotosin 45 mg/kg verilerek diyabet oluşturuldu. Çam yağı grubundaki sıçanlara haftada iki gün 1 mL/kg dozunda intraperitoneal enjeksiyonla çam yağı ve ayrıca 0,5 mL çam yağı 500 mL içme suyuna ilave edilerek verildi. Bu uygulamalar sekiz hafta boyunca sürdürüldü.Bulgular: Kontrol grubuna göre; STZ grubunun karaciğer dokusunda MDA ve total protein düzeyinin anlamlı bir şekilde p

Keywords

Deneysel diyabet, lipit peroksidasyon, yağ asidi bileşimi, kolesterol, ADEK vitaminleri, sterol, karaciğer

The effect of pine oil on the some alterations in liver tissue of experimental diabetes

Abstract

Objective: The present study was designed to evaluate the impact of pine oil on MDA malondialdehyde , GSH glutathione , total protein, fatty acid composition, ADEK vitamins, cholesterol and some sterols parameters in liver tissue of experimental diabetes in rats.Method: The rats were divided into three groups: control C streptozotocin STZ , streptozotocin STZ + pine oil PO groups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin 45 mg/kg . 1 mL/kg dose pine oil was intraperitoneally injected twice in a week to the streptozotocin STZ + pine oil PO , and additionally 0.5 mL /500 mL dose of pine oil was added to drinking water of this group. The experiment continued for eight weeks.Results: It was observed that MDA and total protein levels were significantly increased p

Keywords

Experimental diabetes, lipid peroxidation, fatty acid composition, cholesterol, ADEK vitamins, sterols, liver

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