Deneysel diyabetin karaciğer dokusunda oluşturduğu bazı değişiklikler üzerine çam yağının etkisi

Yıl 2014, Cilt: 71 Sayı: 3, 113 - 124, 01.09.2014

Ersin Demir Ökkeş Yılmaz

Öz

Amaç: Bu çalışma; deneysel diyabet oluşturulan sıçanlarda çam yağının karaciğer dokusunda yağ asidi bileşimi, malondialdehit MDA , glutatyon GSH , total protein, ADEK vitaminleri, kolesterol ve bazı sterol parametreleri üzerinde etkisinin araştırılması için tasarlandı.Yöntem: Sıçanlar; kontrol K , streptozotosin STZ ve streptozotosin STZ + çam yağı ÇY olmak üzere üç grubu ayrıldı. STZ gruplarına intraperitoneal enjeksiyonla streptozotosin 45 mg/kg verilerek diyabet oluşturuldu. Çam yağı grubundaki sıçanlara haftada iki gün 1 mL/kg dozunda intraperitoneal enjeksiyonla çam yağı ve ayrıca 0,5 mL çam yağı 500 mL içme suyuna ilave edilerek verildi. Bu uygulamalar sekiz hafta boyunca sürdürüldü.Bulgular: Kontrol grubuna göre; STZ grubunun karaciğer dokusunda MDA ve total protein düzeyinin anlamlı bir şekilde p

Anahtar Kelimeler

Deneysel diyabet, lipit peroksidasyon, yağ asidi bileşimi, kolesterol, ADEK vitaminleri, sterol, karaciğer

The effect of pine oil on the some alterations in liver tissue of experimental diabetes

Öz

Objective: The present study was designed to evaluate the impact of pine oil on MDA malondialdehyde , GSH glutathione , total protein, fatty acid composition, ADEK vitamins, cholesterol and some sterols parameters in liver tissue of experimental diabetes in rats.Method: The rats were divided into three groups: control C streptozotocin STZ , streptozotocin STZ + pine oil PO groups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin 45 mg/kg . 1 mL/kg dose pine oil was intraperitoneally injected twice in a week to the streptozotocin STZ + pine oil PO , and additionally 0.5 mL /500 mL dose of pine oil was added to drinking water of this group. The experiment continued for eight weeks.Results: It was observed that MDA and total protein levels were significantly increased p

Anahtar Kelimeler

Experimental diabetes, lipid peroxidation, fatty acid composition, cholesterol, ADEK vitamins, sterols, liver

Kaynakça

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