Effects of rheumatoid arthritis on hearing and vestibular system

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease which is characterized by the passage of primarily CD4 (+) T cells and monocytes into the intravenous inflamed synovial tissue and synovial fluid. The effect of RA on hearing is an issue being discussed. Hearing loss can be conductive, sensorineural or mixed. Conductive hearing loss occurs with the involvement of tympano-ossicular system. Sensorineural hearing loss may have arisen due to the neuritis, vasculitis or ototoxic effects of the drugs used during the treatment. In addition to hearing disorders, RA may also cause vestibular system disorders. Pathophysiology of the vestibular disorders are still unclear. In this review, the effects of RA on hearing and vestibular system were presented with the literature survey.

Key words: Rheumatoid artritis, hearing, conductive hearing loss, Sensorineural hearing loss, vasculitis, vestibular disorder

Keywords

• Rheumatoid artritis, hearing, conductive hearing loss, Sensorineural hearing loss, vasculitis, vestibular disorder

Romatoid Artrit’in işitme ve vestibüler sistem üzerine etkileri

Abstract

Romatoid artrit (RA), CD4 (+) T hücreleri ve monositlerin, damardan inflamasyonlu sinoviyal dokuya ve sinoviyal sıvıya geçmesiyle karakterize, otoimmün bir hastalıktır. RA’nın işitmeye olan etkisi tartışılmaya devam etmektedir. İşitme kaybı sadece sensörinöral veya iletim tipinde olabilir. Ayrıca mikst tip işitme kaybı şeklinde de görülebilmektedir. İletim tipi işitme kaybı, timpano-ossiküler sistemin etkilenmesi ile ortaya çıkmaktadır. Sensörinöral kayıp ise nörit, vaskülit veya hastalığın tedavisi sırasında kullanılan ilaçların ototoksik etkilerine bağlı olarak ortaya çıkabilmektedir. RA, işitme bozukluğuna ek olarak vestibuler sistem bozukluğuna da sebep olabilmektedir. Vestibuler bozukluğun fizyolojisi tam açıklanamamıştır. Bu derlemede, RA’nın işitme ve vestibüler sistem üzerindeki etkileri, literatür bilgileri ışığında sunulmuştur.

Anahtar kelimeler: Romatoid artrit, işitme, iletim tipi işitme kaybı, sensörinöral tip işitme kaybı, vaskülit, vestibüler bozukluk

Keywords

• Romatoid artrit, işitme, iletim tipi işitme kaybı, sensörinöral tip işitme kaybı, vaskülit, vestibüler bozukluk

References

1. Appelboom T, Halberg P. History. In: Hochberg M, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds). Rheumatology. 3rd Edition. Spain. The Mosby Company. 2003. p: 753-6.
2. Doğan M, Fişenk F. Romatoid Artritin Otorinolaringolojik Bulguları. K.B.B. ve Baş Boyun Cerrahisi Dergisi 1999; 7: 71-78.
3. Takatsu M, Higaki M, Kinoshita H, Mizushima Y, Koizuka I. Ear Involvement in Patients with Rheumatoid Arthritis. Otology & Neurotology 2005; 26: 755-761.
4. Colletti V, Fiorino FG, Bruni L, Biasi D. Middle earmechanics in subjects with rheumatoid arthritis. Audiology 1997; 36: 136-146.
5. Dikici O. Romatoid Artritli Hastalarda Odyolojik Testler ve Geçici Uyarılmış Otoakustik Emisyonlar. Uzmanlık tezi, Kırıkkale, 2008.
6. Rigual NR. Otolaryngologic manifestations of rheumatoid arthritis. Ear Nose Throat J 1987; 66: 18-22.
7. Heyworth T, Liyanage SP. A pilot survey of hearing loss in patients with rheumatoid arthritis. Scand J Rheumatol 1972; 1: 81-3.
8. Goodwill CJ, Lord IJ, Knill-Jones RP. Heraing in rheumatoid arthritis-result of audiometry in 76 patients. Ann Rheum Dis 1971; 30: 329-31.

9. Gussen R. Atypical ossicle joint lesions in rheumatoid arthritis with sicca syndrome (Sjögren’s syndrome). Arch Otolaryngol 1977; 103: 281-3.
10. Moffat DA, Ramsden RT, Rosenberg JN. Otoadmittance measurements in patients with rheumatoid arthritis. J Laryngol Otol 1977; 91: 917-27.
11. Biasi D, Fiorino F,Carletto A, Caramaschi P, Zeminian S. Milde ear function in rheumatoid arthritis: a multiple frequency tympanometric study. Clinical and Experimental Rheumatology1996; 14: 243-7.
12. Murdin L, Patel S, Walmsley J, Yeoh LH. Hearing difficulties are common in patients with rheumatoid arthritis. Clin Rheumatol 2008; 27: 637-40.
13. Elwany S, El Garf A, Kamel T. Hearing and middle earfunction in rheumatoid arthritis. J Rheumatol 1986; 13: 878-81.
14. Raut VV, Cullen J. Hearin Loss in Rheumatoid Arthritis. The Journal of Otolaryngology 2001; 30: 289-94.
15. Reiter D, Konkle DF, Mayers AR. Middle ear immitance in rheumatoid artritis. Arch Otolaryngol 1980; 106: 114-7.
16. Goodwill CJ, Lord IJ, Knill-Jones RP. Hearing in rheumatoid arthritis; a clinical and audometric survey. Ann Rheum Dis 1972; 31: 170-3.
17. Copeman WSC. Rheumatoid otoarthritis? Br Med J 1963; 2: 1526-7.
18. Rosenberg JN, Moffat DA, Ramsden RT. Milde ear functions in rheumatoid arthritis. Ann Rheum Dis 1978; 37: 522-4.
19. Kakani RS, Mehra YN, Deodhar SD, Mehta S. Audiovestibular functions in Rheumatoid Arthritis. The Journal of Otolaryngology 1990; 19: 100-2.
20. Etholm B, Belal A. Senile changes in the middle ear joints. Ann Otol Rhinol Laryngol 1974; 84: 49-54.
21. Tunçel İ, Özkarakaş H, Aydın Ö, Dursun N, Dursun E, Akdeniz Ö. Romatoid Artritin Ortakulak Kemikçik Eklemleri Üzerindeki Etkilerine Odyometrik ve İmpedansmetrik Yaklaşım. PTT Hastanesi Tıp Dergisi. 1999; 21: 145-8.
22. Magaro M, Zoli A, Altomonte L, et. al. Sensorineural hearing loss in rheumatoid arthritis. Clin Exp Rheumatol 1990; 8: 487-90.
23. Kastanioudakis I, Skevas A, Danielidis V, Tsiakou E, DrososA, Moustopoulos H. Inner ear involvement in rheumatoid arthritis: a prospective clinical study. J Laryngol Otol 1995; 109: 713-8.
24. Özcan M, Karakus MF, Gündüz OH, Tuncel Ü, Şahin H. Hearing loss and middle ear involvement in rheumatoid arthritis. Rheumatol Int 2002; 22: 16-9.
25. Salvinelli F, D'Ascanio L, Casale M, Vadacca M, Rigon A, Afeltra A. Auditory pathway in rheumatoid arthritis. A comparative study and surgical perspectives. Acta Otolaryngol. 2006; 126: 32-6.
26. Callejo FJG, TobíasNC, NM Fernández, CP Vernetta, IA Castañeira, JM Algarra. Hearing Impairment in Patients With Rheumatoid Arthritis. Acta Otorrinolaringol Esp. 2007; 58: 232-8.
27. Oztürk A, Yalçin S, Kaygusuz I, ve ark. High-frequency hearing loss and middle ear involvement in rheumatoid arthritis. Am J Otolaryngol. 2004; 25: 411-7.
28. Şahin L, Özdemir İ, Çallı Ç, Kopar A, Sezgin K, Pınar E. Romatoid Artritte Orta Kulak Eklemlerinin Tutulumunun Odyometrik Açıdan Değerlendirilmesi. Turkish Archives of Otolaryngology. 2004; 42: 204-9.
29. Baradaranfar MH, Doosti A. A survey of relationship between rheumatoid arthritis and hearing disorders. Acta Med Iran 2010; 48: 371-3.
30. Ashok Murthy V, Mohan Kumar J. Rheumatoid factor and hearing loss. Indian J Otolaryngol Head Neck Surg 2012; 64: 364-5.
31. Dikici O, Muluk NB, Tosun AK, Unlusoy I. Subjective audiological tests and transient evoked otoacoustic emissions in patients with rheumatoid arthritis: analysis of the factors affecting hearing levels. Eur Arch Otorhinolaryngol 2009; 266: 1719-26.
32. King J, Young C, Highton J, Smith PF, Darlington CL. Vestibulo-ocular, optokinetic and postural function in humans with rheumatoid arthritis. Neurosci Lett. 2002; 328: 77-80.
33. Ferrara P, Modica A, Adelfio M, Sallì L, Pappalardo A. Audio-vestibular changes in patients with rheumatoid arthritis. Minerva Med. 1988; 79: 1043-7.
34. Yilmaz S, Erbek S, Erbek SS, Ozgirgin N, Yucel E. Abnormal electronystagmography in rheumatoid arthritis. Auris Nasus Larynx. 2007; 34: 307-11.
35. Özkırış M, Kapusuz Z, Günaydın İ, Kubilay U, Pırtı İ, Saydam L. Does rheumatoid arthritis have an effect on audiovestibular tests? Eur Arch Otorhinolaryngol. 2014; 271: 1383-7.