Kronik obstrüktif akciğer hastalığının akut alevlenmesi ile nötrofil-lenfosit oranı ve serum ürik asit düzeyleri arasındaki ilişki

Year 2017, , 105 - 112, 01.06.2017

Nalan Ogan Sezen Bağlan Uzunget , Berkay Ekici

https://doi.org/10.18663/tjcl.286607

Abstract

Amaç: Kronik inflamasyon,
kronik obstrüktif akciğer hastalığında (KOAH) patojenik bir rol oynamaktadır.
Dolaşımdaki nötrofil-lenfosit oranı (N / L oranı), serum ürik asit ve
gama-glutamil transferaz (GGT) düzeylerindeki artış, sistemik bir iltihabın
göstergesi olabilir.

Bu çalışmanın amaı KOAH'lı hastalarda biyolojik belirteç olarak kan
nötrofil-lenfosit (N / L) oranı ile serum ürik asit ve gama-glutamil transferaz
(GGT) düzeylerinin muhtemel rolü üzerindeki olası değerini değerlendirmektir.

Gereç ve Yöntemler: Retrospektif bir
çalışma.Gereç ve Yöntem: Örneklem, KOAH'ın stabil ve akut alevlenmesi için
göğüs hastalıkları bölümümüze başvuran 260 hastadan (stabil KOAH, n = 68,
KOAH'ın akut alevlenişi, n = 192) oluşturuldu.

Bulgular: KOAH hastalarının akut
alevlenmesinde yüksek N / L oranları ve serum ürik asit seviyeleri tespit
edildi (p <0.01). Sigara (paket-yıllar) ile N / L oranı ve C-reaktif
protein düzeyleri arasında pozitif korelasyon bulundu (sırasıyla p = 0.014; r =
0.153 ve p = 0.001; r = 0.252).

Sonuçlar: Çalışmamız, akut
 KOAH alevlenmesi olan hastalarda N / L oranı ve serum ürik asit
düzeylerinin belirgin olarak daha yüksek olduğunu göstermiştir. Kronik
obstrüktif akciğer hastalığı ile bu parametreler arasındaki ilişkilerle ilgili
olarak, rutin klinik uygulamada diğer risk faktörlerinin yanında hastalık
yükünü belirlemek için kullanılabilirler. 

Keywords

kronik obstriktif akciğer hastalığı, nötrofil lenfosit oranı inflamasyon, C reaktif protein, serum ürik asit, inflamasyon

The relationship between acute exacerbation of chronic obstructive pulmonary disease and neutrophile-to-lymphocyte ratio, serum uric acid and gamma-glutamyl transferase levels

Abstract

Aim: Chronic inflammation
plays a pathogenic role in chronic obstructive 
pulmonary disease. Increase in the ratio of circulating neutrophil to
lymphocyte ratio (NLR), serum uric acid and gamma-glutamyl transferase (GGT) levels  may serve as a marker of systemic
inflammation. The aim of this study is to evaluate the potential predictive
value of blood neutrophil-to- lymphocyte NLR and possible role of serum uric
acid and gamma-glutamyl transferase levels as biomarkers in chronic obstructive
pulmonary disease patients.

Material and Methods: The sample was derived from a population
of 276 patients admitted for acute exacerbation of chronic obstructive
pulmonary disease to our respiratory medicine department.

Results: Higher N/L ratios,
uric acid and GGT levels were detected in chronic obstructive pulmonary disease
patients than in the controls (P < 0.001). Positive correlations between
smoking (pack-years) and NLR, serum GGT, uric acid, and C- reactive protein
levels were found (P < 0.001; r = 0.339, P < 0.001; r = 0.224, P < 0.001;r
= 0.242,and P < 0.001; r = 0.563, respectively).

Conclusion: Our study demonstrated
that NLR, serum GGT and uric acid levels are significantly higher in patients
with chronic obstructive  pulmonary
disease. With regard to the associations between chronic obstructive pulmonary
disease and these parameters, they can be used to determine disease burden
besides other risk factors in routine clinical practice.

Keywords

inflammation, C- reactive protein, Chronic obstructive pulmonary disease, neutrophil/lymphocyte ratio, serum uric acid

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