Clinical use of specific markers TAS, TOS, PON and IL-6 by the evaluation of kidney damage in patients receiving SWL treatment

Abstract

Aim: Beside efficacy of the shock wave lithotripsy (SWL) procedure, also its negative effects on the kidneys, its relation with the oxidant/antioxidant balance and the search after biomarkers for the detection of this negative effect gained interest in the recent years. The aim of the study is to investigate the possible usage of  total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), Paraoxonase-1    (PON-1) and Interleukin 6 (IL-6) parameters as biomarkers for renal injury/trauma  in the early period by patients undergoing SWL due to kidney stones.

Material and Methods: Forty patients receiving SWL therapy due to kidney stones were included to study by collecting their blood samples before and 2 hours after the procedure.

Results: It was observed that SWL therapy has deteriorated the oxidant/antioxidant balance in terms of the oxidants by analyzing the increase of IL-6 (P <0,01) and decrease in PON-1 (P = 0.049). There was no change observed in TAS (P = 0.178) and TOS (P = 0.175) and OSI (P = 0.551) parameters.

Conclusion: This has shown that IL-6 and PON-1 may be more sensitive markers of renal injury after SWL in early period.

Keywords

• Shock Wave Lithotripsy (SWL)
• Total Antioxidant Status (TAS)
• Total Oxidant Status (TOS)
• Oxidative Stress Index (OSI)
• Paraoxonase-1 (PON-1)
• Interleukin-6 (IL-6)

SWL tedavisi alan hastalarda böbrek hasarının değerlendirilmesinde özel markırlar: TAS, TOS, PON ve IL-6

Abstract

Amaç: Şok dalga litotripsi (SWL) prosedürünün böbrek taşları üzerine açık etkinliğinin yanı sıra böbrekler üzerindeki olumsuz etkileri, oksidan/antioksidan denge ile ilişkisi ve bu olumsuz etkinin saptanması için biyomarkır arayışları son yıllarda ilgi çekmektedir. Bu çalışmanın amacı böbrek taşı nedeniyle SWL tedavisi uygulanan hastalarda erken dönemde böbrek hasarı/travma belirlenmesinde biyomarkır olarak toplam antioksidan status (TAS), toplam oksidan status (TOS), oksidatif stres indeksi (OSI), Paraoksonaz-1 (PON-1) ve Interlökin-6 (IL-6) parametrelerinin olası kullanımını araştırmaktır.

Gereç ve Yöntemler: Böbrek taşları nedeniyle SWL tedavisi alan 40 hasta işlemden önce ve 2 saat sonra kan örnekleri toplanarak çalışmaya dahil edildiler.

Bulgular: SWL tedavisinin oksidan/antioksidan dengesini, IL-6 artışı (P <0,01) ve PON-1 azalması (P = 0.049) ile oksidan parametreler yönünde bozduğu belirlenmiştir. TAS (P = 0.178), TOS (P = 0.175) ve OSI (P = 0.551) parametrelerinde herhangi bir değişiklik gözlenmemiştir.

Sonuç: IL-6 ve PON-1'in SWL sonrası erken dönemde renal hasarın belirlenmesinde daha hassas belirteçler olabileceği gösterilmiştir.

Keywords

• Şok Dalga Litotripsi (SWL)
• Toplam Antioksidan Status (TAS)
• Toplam Oksidan Status (TOS)
• Oksidatif Stres İndeksi (OSI)
• Paraoksonaz-1 (PON-1)
• İnterlökin-6 (IL-6)

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