Clinical use of specific markers TAS, TOS, PON and IL-6 by the evaluation of kidney damage in patients receiving SWL treatment

Yıl 2018, , 173 - 178, 30.09.2018

Ercan Yuvanc , Devrim Tuglu , Serhan Gur Tunc Ozan , Üçler Kısa , Ertan Batislam Erdal Yılmaz

https://doi.org/10.18663/tjcl.432886

Öz

Aim: Beside efficacy of the shock wave
lithotripsy (SWL) procedure, also its negative effects on the kidneys, its relation
with the oxidant/antioxidant balance and the search after biomarkers for the
detection of this negative effect gained interest in the recent years. The aim
of the study is to investigate the possible usage of  total antioxidant status (TAS), total oxidant
status (TOS), oxidative stress index (OSI), Paraoxonase-1    (PON-1) and Interleukin 6 (IL-6) parameters
as biomarkers for renal injury/trauma  in
the early period by patients undergoing SWL due to kidney stones.

Material
and Methods: Forty patients receiving SWL therapy due to kidney stones were
included to study by collecting their blood samples
before and 2 hours after the procedure.

Results: It was observed that SWL therapy has
deteriorated the oxidant/antioxidant balance in terms of the oxidants by analyzing
the increase of IL-6 (P <0,01) and
decrease in PON-1 (P = 0.049). There
was no change observed in TAS (P =
0.178) and TOS (P = 0.175) and OSI (P = 0.551) parameters.

Conclusion:
This has shown
that IL-6 and PON-1 may be more sensitive markers of renal injury after SWL in
early period.

Anahtar Kelimeler

Shock Wave Lithotripsy (SWL), Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Paraoxonase-1 (PON-1), Interleukin-6 (IL-6)

SWL tedavisi alan hastalarda böbrek hasarının değerlendirilmesinde özel markırlar: TAS, TOS, PON ve IL-6

Öz

Amaç: Şok
dalga litotripsi (SWL) prosedürünün böbrek taşları üzerine açık etkinliğinin
yanı sıra böbrekler üzerindeki olumsuz etkileri, oksidan/antioksidan denge ile
ilişkisi ve bu olumsuz etkinin saptanması için biyomarkır arayışları son
yıllarda ilgi çekmektedir. Bu çalışmanın amacı böbrek taşı nedeniyle SWL
tedavisi uygulanan hastalarda erken dönemde böbrek hasarı/travma
belirlenmesinde biyomarkır olarak toplam antioksidan status (TAS), toplam
oksidan status (TOS), oksidatif stres indeksi (OSI), Paraoksonaz-1 (PON-1) ve
Interlökin-6 (IL-6) parametrelerinin olası kullanımını araştırmaktır.

Gereç ve Yöntemler: Böbrek
taşları nedeniyle SWL tedavisi alan 40 hasta işlemden önce ve 2 saat sonra kan
örnekleri toplanarak çalışmaya dahil edildiler.

Bulgular: SWL
tedavisinin oksidan/antioksidan dengesini, IL-6 artışı (P <0,01) ve PON-1
azalması (P = 0.049) ile oksidan parametreler yönünde bozduğu belirlenmiştir. TAS
(P = 0.178), TOS (P = 0.175) ve OSI (P = 0.551) parametrelerinde herhangi bir
değişiklik gözlenmemiştir.

Sonuç: IL-6
ve PON-1'in SWL sonrası erken dönemde renal hasarın belirlenmesinde daha hassas
belirteçler olabileceği gösterilmiştir.

Anahtar Kelimeler

Şok Dalga Litotripsi (SWL), Toplam Antioksidan Status (TAS), Toplam Oksidan Status (TOS), Oksidatif Stres İndeksi (OSI), Paraoksonaz-1 (PON-1), İnterlökin-6 (IL-6)

Kaynakça

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