Lomber manyetik rezonans görüntüleme erkeklerde osteoporozu tahmin etmek için kullanılabilir mi?

Year 2025, Volume: 16 Issue: 3, 452 - 458, 30.09.2025

Pınar Özge Başaran , Mehmet Büyükşireci

https://doi.org/10.18663/tjcl.1635556

Abstract

Amaç: Bu çalışmanın amacı, erkek hastalarda Dual Energy X-ray absorpsiyometrisi (DXA) ve manyetik rezonans görüntüleme (MRI) bulgularını karşılaştırmak ve osteoporozu teşhis etmede MRI'nin etkinliğini araştırmaktır
Gereç ve Yöntemler: Bu prospektif, kontrollü çalışmaya DXA ile osteoporoz tanısı konmuş 26 erkek ve osteoporozu olmayan 26 erkek dahil edildi; hepsinin lomber MRI ile sagital T1 ağırlıklı görüntüleri (T1WI) incelendi. Lomber vertebra 1–4'ün (L1–L4) sinyal-gürültü oranı (SNR) ölçümleri ve bu SNR değerlerinden türetilen M-skorları için T1WI görüntülerini kullanan yeni bir kantitatif yaklaşım hesaplandı ve DXA T skorlarıyla ilişkisi araştırıldı.
Bulgular: Osteoporozlu erkeklerde ortalama vertebra SNR değerleri şu şekilde bulundu: L1 vertebra 78.30 (18.16-185.98), L2 vertebra 77.47 (16.64-152.12), L3 vertebra 65.15 (16.34-151.72), L4 vertebra 63.53 (15.02-151.52), L1-L4 vertebra ortalaması ise 72.54 (16.49-161.24). Kontrol grubuyla karşılaştırıldığında tüm değerler istatistiksel olarak anlamlıydı. Osteoporozlu erkeklerde M değeri 1.66 (0.98-5.86) olarak ölçülürken, kontrol grubunda 0.77 (0.88-1.06) olarak bulundu (p = 0.018). Osteoporozlu erkek hastalarda M skorunun L1-L4 lomber vertebraların DXA değerleriyle negatif korelasyon gösterdiği bulundu (r = -0,408, p = 0,029). M skoru için optimal kesim değeri 0,38 iken bu değer ile duyarlılık %69,2 ve özgüllük %73,1 olarak saptandı.
Sonuç: M skoru, ek radyasyona gerek kalmadan ciddi komplikasyonlar gelişmeden önce yüksek riskli hastaların erken tanısı ve tedavisi için erkek hastalarda osteoporoz için bir tarama yöntemi olarak kullanılabilir.

Keywords

manyetik rezonans görüntüleme , dual energy X-ray absorpsiyometri , osteoporoz , erkekler

Ethical Statement

This study was reviewed and approved by The Human Institutional Ethics Committee of the Hitit University (14.12.2023 number 2023-171).

Can lumbar magnetic resonance imaging be used to predict osteoporosis in men?

Abstract

Aim: This study aims to compare the findings of Dual Energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) in male patients and investigate MRI's effectiveness in diagnosing osteoporosis
Material and Methods: This prospective, controlled study included 26 men diagnosed with osteoporosis by DXA and 26 men without osteoporosis, all of whom underwent lumbar MRI, with sagittal T1-weighted images (T1WI). A novel quantitative approach utilizing T1WI images for signal-to-noise ratio (SNR) measurements of lumbar vertebrae 1–4 (L1–L4) and M-scores derived from these SNR values has been calculated and the relationship with DXA T scores was investigated.
Results: In men with osteoporosis, the average vertebra SNR values were found as follows: L1 vertebra 78.30 (18.16-185.98), L2 vertebra 77.47 (16.64-152.12), L3 vertebra 65.15 (16.34-151.72), L4 vertebra 63.53 (15.02-151.52), and the average of L1-L4 vertebrae was 72.54 (16.49-161.24). Compared to the control group, all values were statistically significant. The M value was measured as 1.66 (0.98-5.86) in men with osteoporosis, while it was 0.77 (0.88-1.06) in the control group (p = 0.018). In male patients with osteoporosis, the M score was found to be negatively correlated with the DXA values of the L1-L4 lumbar vertebrae (r = -0.408, p = 0.029). The optimal cutoff value for the M score was 0.38, which yielded a sensitivity of 69.2% and a specificity of 73.1%.
Conclusion: The M score can be used as a screening method for osteoporosis in male patients for early diagnosis and treatment of high-risk patients before serious complications develop without additional radiation.

Keywords

magnetic resonance imaging , dual energy X-ray absorptiometry , osteoporosis , men

Ethical Statement

This study was reviewed and approved by The Human Institutional Ethics Committee of the Hitit University (14.12.2023 number 2023-171) and the study was carried out by the principles of the Declaration of Helsinki. Informed Consent Statement: Before enrolling, all participants completed an informed consent form

Supporting Institution

None

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