Parsiyel ön çapraz bağ yırtığı olan hastalarda %5 dekstroz proloterapisinin etkinliğinin değerlendirilmesi

Year 2025, Volume: 16 Issue: 3, 432 - 438, 30.09.2025

İlker Solmaz

https://doi.org/10.18663/tjcl.1710550

Abstract

Amaç: Proloterapi, kas-iskelet yaralanmalarının iyileşmesini desteklemeyi amaçlayan rejeneratif bir enjeksiyon tedavisidir. Bu çalışma, ön çapraz bağ (ACL) yırtıkları olan hastalarda %5 dekstroz proloterapisinin ağrı seviyeleri ve fonksiyonel kapasite üzerindeki etkinliğini değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntemler: Bu retrospektif çalışmaya, yaş ve cinsiyete göre 1:1 eşleştirilmiş iki gruba ayrılmış 60 ACL yırtıkları olan hasta dahil edildi. Proloterapi grubu (n = 30) altı seans boyunca aylık %5 dekstroz solüsyonu enjeksiyonları alırken, kontrol grubu (n = 30) sadece fizik tedavi gördü. Ağrı yoğunluğu Görsel Analog Skala (VAS) kullanılarak değerlendirildi ve fonksiyonel sonuçlar başlangıçta ve 3. ve 6. tedavi seanslarından sonra Alt Ekstremite Fonksiyonel Skalası (LEFS) ile ölçüldü.
Bulgular: İki grup arasında temel demografik ve klinik özellikler benzerdi. Üçüncü seansta, proloterapi grubu kontrol grubuna kıyasla önemli ölçüde azalmış ağrı gösterdi (VAS: 5,2 ± 1,1'e karşı 7,9 ± 0,9; p < 0,001). Altıncı seansta, proloterapi grubunda kontrol grubuna kıyasla daha da önemli ağrı azalması gözlemlendi (VAS: 2,8 ± 1,2'ye karşı 7,3 ± 1,0; p < 0,001). Proloterapi grubunda fonksiyonel kapasite, kontrol grubuna kıyasla altıncı seansta önemli ölçüde iyileşti (LEFS: 68,6 ± 8,5'e karşı 52,4 ± 7,3; p < 0,001).
Sonuç: %5 dekstroz proloterapisi uygulaması, ACL yırtıkları olan hastalarda ağrıyı önemli ölçüde azalttı ve fonksiyonel kapasiteyi iyileştirdi. Proloterapi, dizdeki bağ yaralanmaları için etkili bir minimal invaziv tedavi seçeneği olarak hizmet edebilir.

Keywords

dekstroz , fonksiyonel kapasite , diz , bağ yaralanması , ağrı , proloterapi

Ethical Statement

Çalışma Helsinki Bildirgesi’ne uygun olarak yürütüldü ve Sağlık Bilimleri Üniversitesi, SBÜ Gülhane Eğitim ve Araştırma Hastanesi GETAT Klinik Araştırmalar Etik Kurulu’ndan onay alındı ​​(Tarih: 05.02.2025, Karar No: 2025/2).

Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears

Abstract

Aim: Prolotherapy is a regenerative injection treatment aimed at promoting the healing of musculoskeletal injuries. This study aimed to evaluate the effectiveness of 5% dextrose prolotherapy on pain levels and functional capacity in patients with partial anterior cruciate ligament (ACL) injuries.
Materials and Methods: This retrospective study reviewed medical records of 60 patients with partial ACL tears who were matched 1:1 based on age and sex into two groups: a prolotherapy group (n = 30), who had received monthly injections of 5% dextrose solution for six sessions, and a control group (n=30), who had undergone physical therapy alone. Pain intensity was retrospectively assessed using the Visual Analog Scale (VAS), and functional outcomes were evaluated using the Lower Extremity Functional Scale (LEFS) from baseline records and after the 3rd and 6th treatment sessions.
Results: Baseline demographic and clinical characteristics were similar between the two groups. By the third session, the prolotherapy group showed significantly reduced pain compared to the control group (VAS: 5.2 ± 1.1 vs. 7.9 ± 0.9, p < 0.001). By the sixth session, further significant pain reduction was observed in the prolotherapy group compared to controls (VAS: 2.8 ± 1.2 vs. 7.3 ± 1.0, p < 0.001). Functional capacity significantly improved in the prolotherapy group by the sixth session compared to the control group (LEFS: 68.6 ± 8.5 vs. 52.4 ± 7.3, p < 0.001).
Conclusion: Administration 5% dextrose prolotherapy significantly reduced pain and improved functional capacity in patients with ACL tears. Prolotherapy may serve as an effective minimally invasive treatment option for ligamentous injuries of the knee.

Keywords

dextrose , functional capacity , knee , ligament injury , pain , prolotherapy

Ethical Statement

The study was performed in accordance with the Declaration of Helsinki, and was approved by the Health Sciences University, SBU Gulhane Training and Research Hospital GETAT Clinical Research Ethics Committee (Date: 05.02.2025, Decision No: 2025/2).

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