Genetic Inheritance of Developmental Dysplasia of the Hip: Case Report

Abstract

Developmental dysplasia of the hip (DDH) is a disease in which the dynamics of the hip structures deteriorates due to various reasons. It may develop in the prenatal, natal, or postnatal period. Genetic inheritance is an important risk factor. The diagnosis of the disease is important, especially in the primary care. Herein, we present a mother and a daughter with DDH to emphasize the genetic inheritance of the disease.

Gelişimsel kalça displazisi, kalçayı oluşturan yapıların çeşitli nedenlerle yapısal bozulma gösterdiği dinamik bir hastalıktır. Prenatal, natal veya postnatal gelişebilmektedir. Genetik geçişi önemlidir. Özellikle birinci basamakta hastalığın tespiti gerekmektedir. Bu çalışmada, gelişimsel kalça displazisi tanılı anne ve kız hasta sunulmuştur. Hastalığın özellikle genetik geçişi üzerinde durulmuştur.

 

Keywords

• Developmental dysplasia,hip,genetic inheritance

References

1. 1. Murray KJ, Azari MF. Chiropractic management of low back pain in a 75-year- old man with bilateral developmental hip dysplasia. J Chiropr Med 2015;14(1):46-50.
2. 2. Yıldız K, Ezirmik N. Multifaktöriyel bir hastalık olarak gelişimsel kalça displazisi. Uludağ Üniversitesi Tıp Fakültesi Dergisi 2014;40(1):41-47.
3. 3. Bilgen S, Sarısözen B. Gelişimsel kalça displazisi. Güncel Pediatri 2005; 2:18-21.
4. 4. Filipe G, Carlos H. Use of the pavlik harness in treating conge-nital dislocation of the hip. J Pediatr Orthop 1982; 20:357-62.
5. 5. Ege R. Dkç’de belirtiler ve bulgular. Ege R (editör). Kalça Cerrahisi Ve Sorunları. Ankara: Thk Basımevi;1994. p.217-35.
6. 6. Cady RB. Developmental dysplasia of the hip: definition, recognition, and prevention of late sequeale. Pediatric Ann 2006; 35:92-101.
7. 7. Sewell M, Rosendahl K, Eastwood D. Developmental dysplasia of the hip clinical review. British Medical Journal 2009;339: b4454.
8. 8. Kaya T. Kas iskelet-yumuşak doku radyolojisi. 1.baskı. İstanbul: Nobel & Güneş Kitap Basım; 2008. p.12:343.

9. 9. Wang K, Shi D, Zhu P, Dai J, Zhu L, Zhu H, et al. Association of a single nucleotide polymorphism in tbx4 with developmental dysplasia of the hip: a case-control study. Osteoarthritis and Cartilage 2010;18(12):1592–5. 10. Shi D, Dai J, Zhu P, Qin J, Zhu L, Zhu H, et al. Association of the d repeat polymorphismin the aspn gene with developmental dysplasia of the hip: a case-control study in han chinese. Arthritis Research &Therapy 2011;13(1): R27.
10. 11. Jia J, Li L, Zhao Q, Zhang L, Ru J, Liu X, et al. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-a2 with developmental dysplasia of the hip: a case-control study. Osteoarthritis Cartilage 2012;20(1):60–63. 12. Shi D, Sun W, Xu X, Hao Z, Dai J, Xu Z, et al. A replication study for the association of rs726252 in pappa2 with developmental dysplasia of the hip in chinese han population. Biomed Res Int 2014; 2014:979520.
11. 13. Hao Z, Dai J, Shi D, Xu Z, Chen D, Zhao B, et al. Association of a single nucleotide polymorphism in hoxb9 with developmental dysplasia of the hip: a case-control study. J Orthop Res 2014;32(2):179-82.
12. 14. Fitch RD. Ultrasound for screening and management of developmental dysplasia of the hip. N C Med J 2014;75(2):142–5.
13. 15. Şen MG, Kartal M, Özçakar N. Management of developmental dysplasia of the hip. Turkish Family Physician 2012;3(4):21-25.
14. 16. Liu T, Zhang X, Li Z, Zeng W. Reconstruction with tibial lengthening for limb length discrepancy in crowe type ıv developmental dysplasia of hip in adulthood. Eur J Orthop Surg Traumatol 2013;23(2):225–31.
15. 17. Ezirmik N, Yıldız K. Önemli bir halk sağlığı problemi olarak gelişimsel kalça displazisi. ADÜ Tıp Fakültesi Dergisi 2013;14(2):13-17.