İlaçların Neden Olduğu Tat ve Koku Alma Bozuklukları

Abstract

Odor and taste are important in vital functions. With taste-taking, human social life and dietary habits are affected all kinds. Besides, odor and taste have quite complex structures at the molecular level. It is claimed that most of the drugs used in the treatment of different diseases lead to disturbances in taste and smell as an undesirable effect. Changes in smell and taste sensations are not considered as medical necessity. This situation does not only cause the patient to live with taste or smell disorder, but also make person to be disaffected by the food and not to enjoy the social aspects of the person's life. The purpose of this review is to describe the effects of drugs on taste and smell sensations and to provide information about the drugs that can cause these effects.

Keywords

• drug,taste,smell,olfactory disorder

References

1. 1. Ackerman BH, Kasbekar N. Disturbances of taste and smell induced by drugs. Pharmacotherapy. 1997; 17(3): 482-496.
2. 2. Kinch MS, Haynesworth A, Kinch SL, Hoyer D. An overview of FDA-approved new molecular entities: 1827–2013. Drug Discovery Today. 2014; 19(8): 1033-1039.
3. 3. Schiffman S. Taste and smell in disease. Part I and Part II. N The New England Journal of Medicine. 1983; 38: 1275-1279.
4. 4. Schiffman SS, Zervakis J. Taste and smell perception in the elderly: Effect of medications and disease. Advances in Food and Nutrition Research. 2002; 44: 247-346.
5. 5. Doty RL, Shah M, Bromley SM. Drug-induced taste disorders. Drug Safety. 2008; 31(3): 199-215.
6. 6. Lötsch J, Knothe C, Lippmann C, Ultsch A, Hummel T, Walter C. Olfactory drug effects approached from human-derived data. Drug Discovery Today. 2015; 20(11): 1398-1406.
7. 7. Schiffman SS. Influence of drugs on taste function. Handbook of Olfaction and Gustation. 2015: 911-926.
8. 8. Schiffman SS. Influence of medications on taste and smell. World Journal of Otorhinolaryngology - Head and Neck Surgery. 2018; 4(1): 84-91.

9. 9. Mann, NM. Management of smell and taste problems. Cleveland Clinic Journal of Medicine. 2002; 69(4): 329-336.
10. 10. Satoh-Kuriwada S, Shoji N, Miyake H, Watanabe C, Sasano T. Effects and Mechanisms of Tastants on the Gustatory-Salivary Reflex in Human Minor Salivary Glands.Biomed Res Int. 2018; 3847075.
11. 11. Kobayashi M, Sasabe T, Shigihara Y, Tanaka M, Watanabe Y. Gustatory Imagery Reveals Functional Connectivity from the Prefrontal to Insular Cortices Traced with Magnetoencephalography. 2011; 6(7): e21736.
12. 12. Bartel DL, Sullivan SL, Lavoie EG, Sévigny J, Finger TE .Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. Journal of Comparative Neurology. 2006; 497(1):1-12.
13. 13. Vandenbeuch A, Tizzano M, Anderson CB, Stone LM, Goldberg D, Kinnamon SC. Evidence for a role of glutamate as an efferent transmitter in taste buds. BMC Neuroscience. 2010; 11: 77.
14. 14. Hussain A, Zhang M, Ucounar HK, Svensson T, Quillery E, Gompel N, Ignell R, Kadow CG. Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines. PLoS Biology. 2016; 14(5): e1002454.
15. 15. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ. Coding of of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003; 112(3): 293-301. 16. Roper SD. Signal transduction and information processing in mammalian taste buds. Pflugers Archiv. 2007; 454(5): 759–776.
16. 17. Naik BS, Shetty N, Maben E. Drug-induced taste disorders. European Journal of Internal Medicine. 2008; 21(3): 240-243.
17. 18. Çırpar Ö, Muluk NB, Arıkan OK. Koku Bozuklukları. Bidder Tıp Bilimleri Dergisi 2012; 4(1): 37-44.
18. 19. Doty RL, Bromley SM, Panganiban WD. Koku Alma Duyusu ve Fonksiyon Bozuklukları. Bölüm 21;Baş & Boyun Cerrahisi Otolarengoloji. eda Bailey BJ, Johnson JT, Newlands SD. Çeviri ed. Korkut N. 4. Baskı; 2011; Ankara, Güneş Tıp Kitabevi
19. 20. Schwartz BS, Doty RL, Monroe C, et al. Olfactory function in chemical workers exposed to acrylate and methacrylate vapors. Am J Pub Health. 1989;79:613-18.
20. 21. Kurtuldu E, Miloğlu Ö, Derindağ G, Özdoğan A. Tat Duyu Bozukluklarına Genel Bakış. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2018; 28(2): 277-283.
21. 22. Tuccori, M, Lapi F, Testi A, Ruggiero E, Moretti U, Vannacci A, Bonaiuti R, Antonioli L, Fornai M and Giustarini G. Drug-induced taste and smell alterations. Drug Safety. 2011; 34(10): 849-859.
22. 23. Loesche W, Bromberg J, Terpenning M, Bretz W, Dominguez B, Grossman N, Langmore S. Xerostomia, xerogenic medications and food avoidances in selected geriatric groups. Journal of the American Geriatrics Society. 1995; 43(4): 401-407.
23. 24. Jackson B, Maher D, Matthews P, McGrath B, Johnston CI. Lack of cross sensitivity between captopril and enalapril. Australian and New Zealand Journal of Medicine . 1988; 18(1): 21-27.
24. 25. Ljunggren Ö, Fredholm BB, Nordstedt C, Ljunghall S, Lerner UH. Role of protein kinase C in bradykinin-induced prostaglandin formation in osteoblasts. European Journal of Pharmacology: Molecular Pharmacology. 1993; 244(2): 111-117.
25. 26. Coulter DM. Eye pain with nifedipine and disturbance of taste with captopril: a mutually controlled study showing a method of postmarketing surveillance. British Medical Journal. 1988; 296(6629): 1086-1088.
26. 27. Briggs, E. Taste disturbances related to medication use. The Consultant Pharmacist. 2009; 24(7): 538-543.
27. 28. Strasser F, Demmer R, Böhme C, Schmitz SFH, Thuerlimann B, Cerny T, Gillessen S. Prevention of docetaxel-or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study. The Oncologist. 2008; 13(3): 337-346.
28. 29. Chen J, Korostyshevsky D, Lee S, Perlstein EO. Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy. PLoS One. 2012; 7(4): e34024.
29. 30. Zubare-Samuelov M, Shaul ME, Peri I, Aliluiko A, Tirosh O, Naim M. Inhibition of signal-termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste-signal termination. American Journal of Physiology-Cell Physiology. 2005; 289(2): C483-C492.
30. 31. Naim M, Shaul ME, Spielman AI, Huang L, Peri I. Permeation of Amphipathic Sweeteners into Taste-Bud Cells and Their Interactions with Post-Receptor Signaling Components: Possible Implications for Sweet-Taste Quality. Sweetness and Sweeteners, American Chemical Society. 2008; 979: 241-255.
31. 32. Gao N, Lu M, Echeverri F, Laita B, Kalabat D, Williams ME, Hevezi P, Zlotnik A, Moyer BD. Voltage-gated sodium channels in taste bud cells. BMC Neuroscience. 2009; 10(1): 20.
32. 33. Persson RE, Izutsu KT, Truelove EL, Persson R. Differences in salivary flow rates in elderly subjects using xerostomatic medications. Oral Surgery, Oral Medicine, Oral Pathology. 1991; 72(1): 42-46.
33. 34. Ercetin S, Haznedaroglu IC, Mevlut K, Aktaş A, Goker H, Ozdemir O, Kirazlı S, Fırat HC. Safety and efficacy of Ankaferd Blood Stopper in dental surgery. International Journal of Hematology and Oncology. 2010; 27(4): 001-005.
34. 35. Riera CE, Vogel H, Simon SA, Coutre J. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2007; 293(2): R626-R634.
35. 36. Xu H, Tian W, Fu Y, Oyama TT, Anderson S, Cohen DM. Functional effects of non-synonymous polymorphisms in the human TRPV1 gene. American Journal of Physiology-Renal Physiology. 2007; 293(6): F1865-F1876.
36. 37. Schiffman SS. Effects of aging on the human taste system. Annals of the new york Academy of Sciences. 2009; 1170(1): 725-729.
37. 38. Schiffman SS. Critical illness and changes in sensory perception. Proceedings of the Nutrition Society. 2007; 66(3): 331-345.
38. 39. Lötsch J, Daiker H, Hähner A, Ultsch A, Hummel T. Drug-target based cross-sectional analysis of olfactory drug effects. European Journal of Clinical Pharmacology. 2015; 71(4): 461-471.
39. 40. Del ABR, Nobre GF, Baglie S, Lopes RM, Simões R, Rosalen P, Franco L, Moreno R, Abib JE, Groppo F. A PK/PD approach on the effects of clarithromycin against oral and nasal microbiota of healthy volunteers. International journal of clinical pharmacology and therapeutics. 2009; 47(2): 96-103.
40. 41. Doty RL. Measurement of chemosensory function. World Journal of Otorhinolaryngology Head and Neck Surgery. 2018; 4(1): 11–28.
41. 42. Settle R.G. The alcoholic's taste perception of alcohol: preliminary findings. Alcohol Research:Current Reviews. 1979; 5: 257–267.
42. 43. Doty RL, Treem J, Tourbier I, Mirza N. A double-blind study of the influences of eszopiclone on dysgeusia and taste function. Pharmacology Biochemistry and Behavior. 2009; 94: 312e318.
43. 44. Altundag A, Cayonu M, Kayabasoglu G, Salihoglu M, Tekeli H, Saglam O, Hummel T. Modified olfactory training in patients with postinfectious olfactory loss. Laryngoscope. 2015; 125(8):1763-6.