Evaluation of the Relationship Between Obesity and Hematological Parameters Associated with Atherosclerosis

Abstract

Introduction: The aim of this study was to evaluate the relationship between obesity parameters and mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLO) and platelet-lymphocyte ratio (PLO), which are among the hemogram parameters shown to be associated with atherosclerosis. Method: The study enrolled 240 individuals admitted to the internal medicine outpatient clinic. Individuals were grouped according to their body-mass index. Obese individuals were divided into three groups as class I, class II and class III obese.
Results: 182 female and 58 male patients were included in the study. The mean age was 45.4±13.0 years and the median body-mass index was 31.4 (26.2–36.5) kg/m2. There was negative correlation between body-mass index and hemoglobin (r=-0.168, p=0.009) and hematocrit (r=-0.188, p=0.003), and a positive correlation was found between body-mass index and MPV (r=0.186, p=0.004). A negative correlation was found between weight and PLO (r=-0.143, p=0.027). There was a positive correlation between the hip circumference and MPV (r=0.155, p=0.016). There was no significant relationship between body-mass index, weight, waist circumference and, hip circumference and other hematological parameters. In the group with BMI ≥30 kg/m2, hemoglobin and hematocrit values were lower and MPV values were higher (p=0.007, p=0.002, p=0.009, respectively). MPV values were higher in class II and III obesity groups than in the class I obesity group. Conclusion: MPV and PLO values correlate with anthropometric measurements. Hemoglobin and hematocrit values decrease as the body-mass index increases.

Keywords

• Atherosclerosis
• complete blood count
• obesity

Project Number

Yok

Ateroskleroz ile İlişkili Hematolojik Parametrelerin Obezite ile İlişkisinin Değerlendirilmesi

Abstract

Giriş: Çalışmanın amacı, obezite parametreleri ile ateroskleroz ile ilişkili olduğu gösterilen hemogram parametrelerinden ortalama trombosit hacmi (MPV), nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranı (PLO) arasındaki ilişkinin değerlendirilmesidir. Yöntem: Çalışmaya İç Hastalıkları polikliniğine başvuran 240 birey alındı. Bireyler vücut-kitle indekslerine göre gruplandırıldı. Obez olan bireyler de kendi içinde sınıf I, sınıf II ve sınıf III obezite olarak 3 gruba ayrıldı. Bulgular: Çalışmaya 182 kadın ve 58 erkek hasta dahil edildi. Yaş ortalaması 45,4±13,0 yıl, vücut-kitle indeks ortancası 31,4 (26,2–36,5) kg/m2 idi. Vücut-kitle indeks ile hemoglobin (r=-0,168, p=0,009) ve hematokrit (r=-0,188, p=0,003) değerleri arasında negatif, vücut-kitle indeks ile MPV (r=0,186, p=0,004) arasında ise pozitif korelasyon bulundu. Kilo ile PLO arasında negatif korelasyon bulundu (r=-0,143, p=0,027). Kalça çevresi ile MPV arasında pozitif korelasyon bulundu (r=0,155, p=0,016). Vücut-kitle indeks, kilo, bel çevresi ve kalça çevresi ile diğer hematolojik parametreler arasında anlamlı bir ilişki bulunamadı. Vücut-kitle indeks ≥30 kg/m2 olan grupta, hemoglobin ve hematokrit değerleri daha düşük, MPV değerleri ise daha yüksek olarak bulundu (sırasıyla p=0,007, p=0,002, p=0,009). MPV değerleri, sınıf II ve III obezite gruplarında, sınıf I obezite grubuna göre daha yüksek bulundu. Sonuç: MPV ve PLO değerleri, antropometrik ölçümlerle korelasyon göstermektedir. Vücut-kitle indeks arttıkça hemoglobin ve hematokrit değerleri azalmaktadır.

Keywords

• Ateroskleroz
• tam kan sayımı
• obezite

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

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