Ateroskleroz ile İlişkili Hematolojik Parametrelerin Obezite ile İlişkisinin Değerlendirilmesi

Year 2020, Volume: 14 Issue: 3, 377 - 383, 20.09.2020

Türkan Paşalı Kilit , Yasemin Kurtoğlu , Celal Kilit , Fatma Koçak , Özlem Genç

https://doi.org/10.21763/tjfmpc.654382

Abstract

Giriş: Çalışmanın amacı, obezite parametreleri ile ateroskleroz ile ilişkili olduğu gösterilen hemogram parametrelerinden ortalama trombosit hacmi (MPV), nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranı (PLO) arasındaki ilişkinin değerlendirilmesidir. Yöntem: Çalışmaya İç Hastalıkları polikliniğine başvuran 240 birey alındı. Bireyler vücut-kitle indekslerine göre gruplandırıldı. Obez olan bireyler de kendi içinde sınıf I, sınıf II ve sınıf III obezite olarak 3 gruba ayrıldı. Bulgular: Çalışmaya 182 kadın ve 58 erkek hasta dahil edildi. Yaş ortalaması 45,4±13,0 yıl, vücut-kitle indeks ortancası 31,4 (26,2–36,5) kg/m2 idi. Vücut-kitle indeks ile hemoglobin (r=-0,168, p=0,009) ve hematokrit (r=-0,188, p=0,003) değerleri arasında negatif, vücut-kitle indeks ile MPV (r=0,186, p=0,004) arasında ise pozitif korelasyon bulundu. Kilo ile PLO arasında negatif korelasyon bulundu (r=-0,143, p=0,027). Kalça çevresi ile MPV arasında pozitif korelasyon bulundu (r=0,155, p=0,016). Vücut-kitle indeks, kilo, bel çevresi ve kalça çevresi ile diğer hematolojik parametreler arasında anlamlı bir ilişki bulunamadı. Vücut-kitle indeks ≥30 kg/m2 olan grupta, hemoglobin ve hematokrit değerleri daha düşük, MPV değerleri ise daha yüksek olarak bulundu (sırasıyla p=0,007, p=0,002, p=0,009). MPV değerleri, sınıf II ve III obezite gruplarında, sınıf I obezite grubuna göre daha yüksek bulundu. Sonuç: MPV ve PLO değerleri, antropometrik ölçümlerle korelasyon göstermektedir. Vücut-kitle indeks arttıkça hemoglobin ve hematokrit değerleri azalmaktadır.

Keywords

Ateroskleroz, tam kan sayımı, obezite

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

Evaluation of the Relationship Between Obesity and Hematological Parameters Associated with Atherosclerosis

Abstract

Introduction: The aim of this study was to evaluate the relationship between obesity parameters and mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLO) and platelet-lymphocyte ratio (PLO), which are among the hemogram parameters shown to be associated with atherosclerosis. Method: The study enrolled 240 individuals admitted to the internal medicine outpatient clinic. Individuals were grouped according to their body-mass index. Obese individuals were divided into three groups as class I, class II and class III obese.
Results: 182 female and 58 male patients were included in the study. The mean age was 45.4±13.0 years and the median body-mass index was 31.4 (26.2–36.5) kg/m2. There was negative correlation between body-mass index and hemoglobin (r=-0.168, p=0.009) and hematocrit (r=-0.188, p=0.003), and a positive correlation was found between body-mass index and MPV (r=0.186, p=0.004). A negative correlation was found between weight and PLO (r=-0.143, p=0.027). There was a positive correlation between the hip circumference and MPV (r=0.155, p=0.016). There was no significant relationship between body-mass index, weight, waist circumference and, hip circumference and other hematological parameters. In the group with BMI ≥30 kg/m2, hemoglobin and hematocrit values were lower and MPV values were higher (p=0.007, p=0.002, p=0.009, respectively). MPV values were higher in class II and III obesity groups than in the class I obesity group. Conclusion: MPV and PLO values correlate with anthropometric measurements. Hemoglobin and hematocrit values decrease as the body-mass index increases.

Keywords

Atherosclerosis, complete blood count, obesity

Project Number

Yok

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