Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi

Öz

Majör depresif bozukluk, kişinin sosyal işlevlerini ve günlük yaşama dair etkinliklerini rahatsız edecek dereceye ulaşmış üzüntü, melankoli veya keder durumudur. İlaç ile tedavisi ise özellikle kişilerin tedaviye olumlu yanıt vermesi noktasında yetersiz ve iyileşme sürecinden uzakta kalmaktadır. Son zamanlarda yapılan çalışmalar insanlarda meydana çıkan bu depresif bozukluklarda beslenmede yer alan vitamin ve minerallerin önemli bir rolü olduğuna yönelik kanıtlar ortaya koymaktadır. Merkezi sinir sistemi üzerindeki etkileri sonucu Folat ve B12 vitamini bu noktada çalışmaların odağı olmaktadır. Çalışmamızda Eskişehir Osmangazi Üniversitesi psikiyatri servisine başvuran ayakta tedavi edilen hastaların Folat ve B12 vitamin düzeyleri incelendi. Bu amaçla 2016 yılında psikiyatri servisine başvuran, B12 vitamin düzeyleri ölçülen 343 hastanın ve Folat düzeyleri ölçülen 250 hastanın verileri retrospektif olarak belirlendi. Elde edilen tüm veriler, SPSS 21 paket programı ile istatistiksel olarak değerlendirildi. Değerlendirme sonucunda, Folat eksikliğinin prevelansı %15,6, B12 vitamin eksikliğinin pravelansı ise %15,45 olarak bulunmuştur. Literatür ile uyumlu çıkan sonuçlarımız için majör depresif bozukluk tanı ve tedavi sürecinde rutin olarak B12 vitamininin ve Folat düzeylerinin takip edilmesi gerektiği söylenebilir. Özellikle antidepresan kullanımının kısıtlanması ve semptomların giderilmesi noktasında yapılacak vitamin takviyeleri ile olumlu sonuçlar alınabileceği yorumu yapılabilir.

Anahtar Kelimeler

• B12,Depresyon,Folat,Psikolojik bozukluklar

Evaluation of Folate and B12 Vitamin Levels in Psychiatric Patients in Eskişehir

Abstract

Major depressive disorder is sadness, melancholy, or grief, which has reached a degree of disturbance for one's social functions and activities of daily living. Drug treatment is inadequate at the situation where people respond positively to treatment, and is far from the recovery process. Recent studies have shown evidence that vitamins and minerals in the diet play an important role in these depressive disorders that occur in humans. The effects on the central nervous system are the resultant Folate and B12 vitamins. In our study, Folate and vitamin B12 levels of outpatients treated with Eskişehir Osmangazi University psychiatric department were examined. For this purpose, 343 patients with vitamin B12 levels and 250 patients with Folate levels who were referred to a psychiatric service in 2016 were retrospectively determined. All the data obtained were evaluated statistically by SPSS 21 package program. As a result of the evaluation, the prevalence of folate deficiency was found to be 15.6% and that of vitamin B12 deficiency was found to be 15.45%. For our results consistent with the literature, it can be said that vitamin B12 and folate levels should be routinely monitored during the diagnosis and treatment of major depressive disorder. Especially, antidepressant use restriction and relieving symptoms can be interpreted as positive results with vitamin supplements.

Keywords

• B12,Depression,Folate,Psychological disorders

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