Effect of mediterranean diet on breast cancer: meta-analysis
Abstract
Objective: In this meta-analysis, we have assessed the effects of Mediterranean Diet on breast cancer.
Methods: Case-control and cross-sectional studies were searched using PubMED, SpringerLink, and Taylor & Francis databases for inclusion in the meta-analysis. We confined our search to the studies conducted and published after year 2000. From all the included studies, geography, sample size, study design, study evaluation method, outcome, risk factors (lowest and highest limit and OR values), and 95% confidence interval data were extracted. Eleven studies with 26361 participants were included of which 10 were case-control studies and 1 was cross-sectional study.
Results: Following the analysis according to the random effects model, it was observed that compliance with the Mediterranean Diet or the high consumption amount of olive oil, seafood, whole grains, vegetables, and fruits in the Mediterranean Diet has a positive effect on breast cancer. The effect size was found to be OR 0.77 (0.68-0.88).
Conclusion: This meta-analysis, including the studies evaluating the effect of Mediterranean diet on breast cancer, concluded that the Mediterranean Diet has positive effects on breast cancer. The risk of breast cancer was found to be decreased with the increased compliance of the Mediterranean Diet.
Keywords
References
- Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941-1953.
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of in-cidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
- Nindrea RD, Aryandono T, Lazuardi L. Breast cancer risk from modifiable and non-modifiable risk factors among women in Southeast Asia: a meta-analysis. Asian Pac J Cancer Prev. 2017;18(12):3201-3206.
- Winters S, Martin C, Murphy D, Shokar NK. Breast Cancer Epidemiology, Prevention, and Screening. Prog Mol Biol Transl Sci. 2017;151:1-32.
- Ferlay JF. GLOBOCAN 2000. Cancer incidence, mortality and prevalence worldwide, version 1.0. IARC Cancerbase. 2001.
- Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975–2018. National Cancer Institute. 2021.
- Turnbull C, Rahman N. Genetic predisposition to breast cancer: past, present, and future. Annu Rev Genomics Hum Genet. 2008;9:321-345.
- Key T, Appleby P, Barnes I, Reeves G; Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst. 2002;94(8):606-616.
- De Cicco P, Catani MV, Gasperi V, Sibilano M, Quaglietta M, Savini I. Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence. Nutrients. 2019;11(7):1514.
- Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer. 2015;112(3):580-593.