HEMATOPOIETIK KÖK HÜCRE NAKLI OLAN HASTALARDA ANEMI VARLIĞININ FIZIKSEL FONKSIYONLAR ÜZERINE ETKISI VAR MIDIR?

Abstract

Amaç: Anemi, hematolojik malignitesi olan hastalarda fiziksel fonksiyonları etkileyebilen bağımsız bir faktör olarak bulunmuştur. Çalışmamızda, hematopoietik kök hücre nakli (HKHN) ile tedavi edilen hastalarda aneminin fiziksel fonksiyonlar üzerine etkisinin belirlenmesi amaçlandı. Yöntem: HKHN ile tedavi edilen toplam 82 hasta retrospektif olarak analiz edildi. Anemi varlığı, WHO standardına göre belirlendi. Fiziksel değerlendirmeler; yorgunluk, el kavrama ve periferik kas kuvveti, fonksiyonel performans ve günlük yaşam aktivitelerini (GYA) içermekteydi. Kaydedilen değişkenler anemisi olan ve olmayan hastalar arasında karşılaştırıldı. Ek olarak, transplantasyon tipi ve HKHN'den bu yana geçen sürenin sonuçlarımız üzerindeki etkisi analiz edildi. Sonuçlar: Anemisi olan hastalarda kuadriseps femoris kas kuvveti, fonksiyonel performans ve GYA düzeyi anemisi olmayan hastalara göre anlamlı olarak daha düşüktü (sırasıyla p=0.025, p=0.001 ve p=0.009). Ek olarak, HKHN'den bu yana geçen süre her iki grupta kontrol edildiğinde, anemi olan ve olmayan hastalar arasında fonksiyonel performans ve GYA'da hala anlamlı fark vardı. Tartışma: HKHN ile tedavi edilen hastalarda anemi varlığının kas gücü, fonksiyonel performans ve GYA düzeyi üzerinde olumsuz pek çok etkileri vardır. Sağlık profesyonelleri, anemili hastaların fonksiyonel sorunları olabileceğinin farkında olmalıdır.

Keywords

• Anemi
• Fonksiyonel performans
• Hematopoietik kök hücre nakli
• Fiziksel fonksiyon

Does the presence of anemia have an impact on physical functions in patients treated with hematopoietic stem cell transplantation?

Abstract

Purpose: Anemia has been found as an independent factor that may influence physical functions in patients with hematological malignancy. We aimed to determine impact of anemia on physical functions in patients treated with hematopoietic stem cell transplantation (HSCT). Methods: A total of 82 patients treated with HSCT were retrospectively analyzed. The presence of anemia was determined in accordance with the WHO standard. Physical examinations were included fatigue, hand grip and peripheral muscle strength, functional performance, and activities of daily living (ADL). We compared recorded variables between patients with and without anemia. Additionally, impact of transplantation type and duration since HSCT on our results were analyzed. Results: Patients with anemia had significantly poorer quadriceps femoris muscle strength, functional performance, and ADL level than patients without anemia (p=0.025, p=0.001, and p=0.009, respectively). Additionally, the duration since HSCT were adjusted in two groups, there was still significant difference in functional performance and ADL between patients with and without anemia (p˂0.05). Conclusion: The presence of anemia in patient treated with HSCT have negative impact on muscle strength, functional performance, and ADL level. Health care professionals should be aware that patients with anemia may have functional problems.

Keywords

• Anemia
• functional performance
• hematopoietic stem cell transplantation
• physical function

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