An early-exercise-mediated adverse reaction associated with platelet-rich plasma therapy.

Abstract

PRP is a well-established autologous therapy with several indications in the musculoskeletal spectrum with a few reported complications. PRP pathophysiologic mechanism remains unclear so cause-effect relationships are difficult to be established. To our knowledge, acute inflammatory reactions associated with intra-articular PRP injection have never been reported. We herein present a rare case of adverse reaction in a patient who exercised after only 16 hours from PRP therapy. She was admitted to hospital with sensation of fever, pain and inflammation of the knee 8 hours after the training session and 24 hours after last PRP injection. Laboratory studies did not reveal any infection sign. Once the clinical picture was resolved, the patient was able to resume previous activity level. In this case an early exercise-mediated stimulus may have played a role as a causative factor.

Keywords

• Growth factors
• Adverse effect
• Knee joint
• Exercise

TROMBOSİTTEN ZENGİN PLAZMA TEDAVİSİNİ TAKİBEN ERKEN EGZERSİZLE İLİŞKİLİ YAN ETKİ: VAKA RAPORU

Abstract

Amaç: PRP, bildirilen birkaç komplikasyonla birlikte kas-iskelet sistemi spektrumunda çeşitli endikasyonları olan köklü bir otolog tedavidir. PRP'nin patofizyolojik mekanizması belirsizliğini koruyor, bu nedenle neden-sonuç ilişkilerinin kurulması zor. Bildiğimiz kadarıyla, eklem içi PRP enjeksiyonu ile ilişkili akut inflamatuar reaksiyonlar hiç bildirilmemiştir. Burada PRP tedavisinden sadece 16 saat sonra egzersiz yapan bir hastada nadir görülen bir advers reaksiyon vakasını sunuyoruz. Yöntem: Eğitim seansından 8 saat sonra ve son PRP enjeksiyonundan 24 saat sonra ateş, ağrı ve dizde iltihaplanma hissi ile hastaneye başvurdu. Sonuçlar: Laboratuvar çalışmaları herhangi bir enfeksiyon belirtisi göstermedi. Klinik tablo düzeldiğinde, hasta önceki aktivite seviyesine devam edebildi. Tartışma: Bu durumda, erken bir egzersiz aracılı uyaran nedensel bir faktör olarak rol oynamış olabilir. PRP tedavisini takiben erken egzersizle ilişkili advers reaksiyon, uyarana aracılık etme yoluyla nedensel bir faktör olarak rol oynamış olabilir.

Keywords

• Büyüme faktörü
• Yan etki
• Diz eklemi
• Egzersiz

References

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