PRİMER SJÖGREN SENDROMLU BİREYLERDE İNTERFERANSİYEL AKIM TEDAVİSİNİN TÜKÜRÜK BEZİ FONKSİYONU ÜZERİNDEKİ ETKİNLİĞİ: TEK KÖR, RANDOMİZE, KONTROLLÜ ÇALIŞMA

Year 2025, Volume: 36 Issue: 2, 164 - 176, 22.09.2025

Aylin Keskin , Bilge Başakcı Çalık , Elif Gur Kabul , Murat Taşçı , Veli Çobankara

https://doi.org/10.21653/tjpr.1552795

Abstract

Amaç: Bu çalışma, interferans akımı (İFA) tedavisinin klinik Pilates egzersizleri (KPE) ile birlikte uygulanmasının primer Sjögren sendromu’nda (pSS) kısa, orta ve uzun vadeli etkilerini araştırmayı amaçladı.
Yöntem: Çalışmaya 36 pSS hastası dahil edildi. Katılımcılar rastgele iki gruba ayrıldı [müdahale grubu (aktif İFA tedavisi + KPE) n=18; kontrol grubu (sham İFA tedavisi + KPE) n=18]. Uyarılmamış tükürük akış hızı ölçümü (uyarılmamış TAHÖ), uyarılmış tükürük akış hızı ölçümü (uyarılmış TAHÖ), sağlık değerlendirme anketi (SDA), ağız sağlığı etki profili-14 (ASEP-14), ağız sağlığıyla ilgili yaşam kalitesi-Birleşik Krallık anketi (ASYK-BK), Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE), kısa form-36 (KF-36) ve Pittsburgh Uyku Kalitesi İndeksi (PUKİ) değerlendirme için kullanıldı. Değerlendirmeler tedavi öncesinde ve tedaviden sonra 8., 20., 32. ve 44. haftalarda yapıldı. Her iki tedavi de 8 hafta boyunca haftada 3 kez uygulandı.
Bulgular: Tedavi öncesi ve sonrası veriler karşılaştırıldığında, müdahale grubunda uyarılmamış ve uyarılmış TAHÖ değerlerinde iyileşme gözlendi (p<0,001). Her iki grupta da SDA, ASEP-14, ASYK-BK, BDE, BAE, KF-36 (fiziksel ve zihinsel bileşenler) ve PUKİ’de iyileşmeler kaydedildi (p<0,05). Tüm parametrelerin tedavi sonrası fark değerleri karşılaştırıldığında, sonuçlar müdahale grubu lehine anlamlıydı (p<0,05). Uyarılmış ve uyarılmamış TAHÖ, SDA, ASEP-14, ASYK-BK, BDE, BAE, KF-36 ve PUKİ analizlerinde, grup ve zaman-grup etkileşim etkileri anlamlı bulundu (p<0,05).
Sonuç: İFA tedavisi, hastalık aktivitesi ve semptomlarda kısa, orta ve uzun vadede güvenle uygulanabilecek etkili bir farmakolojik olmayan tedavi yöntemidir. KPE ise pSS’de psikososyal faktörlerin iyileşmesine olumlu katkı sağlamaktadır.

Keywords

Egzersiz , İnterferansiyel akım , Tükürük , Sjögren sendromu , Kserostomi

Ethical Statement

This study was approved by the Local Ethics Committee for Non-Interventional Clinical Research (Date: December 31, 2018; Number: 60116787-020/90548). All the participants were informed verbally, and informed consent forms were signed.

Supporting Institution

Pamukkale University

Project Number

This study was supported by Pamukkale University Project numbers 2019SABE007.

THE EFFECTIVENESS OF INTERFERENTIAL CURRENT THERAPY ON SALIVARY GLAND FUNCTION IN INDIVIDUALS WITH PRIMARY SJOGREN’S SYNDROME: SINGLE-BLIND RANDOMIZED, CONTROLLED TRIAL

Abstract

Purpose: This study aimed to investigate short-, mid-, and long-term effects of interferential current (IFC) therapy combined with clinical Pilates exercises (CPE) in primary Sjogren’s syndrome (pSS).
Methods: Thirty-six pSS were included. The participants were randomly divided into 2 groups [intervention group (active IFC therapy + CPE) n=18; control group (sham IFC therapy + CPE) n=18]. Unstimulated salivary flow rate measurement (unstimulated SFRM); Stimulated salivary flow rate measurement (stimulated SFRM); health assessment questionnaire (HAQ); Oral Health Impact Profile-14 (OHIP-14); oral health-related quality of life-United Kingdom questionnaire (OHRQOL-UK); Beck Depression Inventory (BDI); Beck Anxiety Inventory (BAI); short form-36 (SF-36), Pittsburgh Sleep Quality Index (PSQI) were used for evaluation. Assessments were conducted pre-treatment and at 8, 20, 32, and 44 weeks post-treatment. Both treatments were applied 3 times weekly for 8 weeks.
Results: When the pre- and post-treatment data were compared, improvement was observed in unstimulated SFRM and Stimulated SFRM values in the intervention group (p<0.001). The improvements were also recorded in HAQ, OHIP-14, OHRQOL-UK, BDI, BAI, SF-36 (physical and mental component), and PSQI in both groups (p<0.05). When the difference values of all parameters were compared post treatment, they were significant in favor of intervention group (p<0.05). Analysis of stimulated and unstimulated SFRM, HAQ, OHIP-14, OHRQOL-UK, BDI, BAI, SF-36, and PSQI revealed significant group and time-by-group interaction effects (p<0.05).
Conclusion: IFC therapy is an effective non-pharmacological treatment method that can be safely applied in the short-term, med-, and long-term in disease activity and symptoms. CPE contribute positively to the improvement of psychosocial factors in pSS.

Keywords

Exercise , Interferential current , Saliva , Sjogren’s syndrome , Xerostomia

Project Number

This study was supported by Pamukkale University Project numbers 2019SABE007.

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