Abstract
Lithium is a mood stabilizer frequently used in bipolar disorder. Because of its narrow therapeutic range, even small fluctuations in serum levels may cause toxicity. As lithium is mainly excreted by the kidneys, disturbances in sodium or fluid balance significantly increase the risk of intoxication (1). This report presents a case of cardiac arrest secondary to lithium toxicity associated with hyponatremia.
Keywords
Lithium intoxication Hyponatremia Cardiac arrest Central pontine myelinolysis Cardiopulmonary resuscitation
References
- Gitlin M. Lithium side effects and toxicity: prevalence and management. Int J Bipolar Disord. 2016;4(1):27.
- Waring WS. Clinical use and toxicity of lithium: pharmacokinetic and toxicokinetic perspectives. Toxicol Rev. 2006;25(4):221–230.
- Grandjean EM, Aubry JM. Lithium: updated human knowledge using an evidence-based approach. Part III: Clinical safety. CNS Drugs. 2009;23(5):397–418.
- Sterns RH. Disorders of plasma sodium—causes, consequences, and correction. N Engl J Med. 2015;372(1):55–65.
- Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581–1589.
- Mannheimer B, Falhammar H, Skov J, Rydén A, Melander O. Drug-induced hyponatremia in clinical care. Eur J Intern Med. 2025;115:106–118. doi:10.1016/j.ejim.2025.04.034.
Abstract
Lityum, bipolar bozukluk tedavisinde sık kullanılan bir duygu durum düzenleyicisidir. Dar terapötik aralığı nedeniyle serum düzeyindeki küçük değişiklikler toksisiteye yol açabilir. Lityum atılımı büyük oranda böbreklerden gerçekleştiğinden, sodyum dengesindeki bozukluklar toksisite riskini artırır (1). Bu olgu, hiponatremi zemininde gelişen lityum intoksikasyonuna bağlı kardiyak arrest nedeniyle sunulmuştur.
Keywords
Lityum intoksikasyonu Hiponatremi Kardiyak arrest Santral pontin miyelinolizis Kardiyopulmoner resüsitasyon
References
- Gitlin M. Lithium side effects and toxicity: prevalence and management. Int J Bipolar Disord. 2016;4(1):27.
- Waring WS. Clinical use and toxicity of lithium: pharmacokinetic and toxicokinetic perspectives. Toxicol Rev. 2006;25(4):221–230.
- Grandjean EM, Aubry JM. Lithium: updated human knowledge using an evidence-based approach. Part III: Clinical safety. CNS Drugs. 2009;23(5):397–418.
- Sterns RH. Disorders of plasma sodium—causes, consequences, and correction. N Engl J Med. 2015;372(1):55–65.
- Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581–1589.
- Mannheimer B, Falhammar H, Skov J, Rydén A, Melander O. Drug-induced hyponatremia in clinical care. Eur J Intern Med. 2025;115:106–118. doi:10.1016/j.ejim.2025.04.034.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Anaesthesiology |
| Journal Section | Short Communication |
| Authors | |
| Submission Date | November 3, 2025 |
| Acceptance Date | November 9, 2025 |
| Publication Date | December 29, 2025 |
| Published in Issue | Year 2025 Volume: 4 Issue: S2 |