CARDIAC ARREST DUE TO LITHIUM INTOXICATION ACCOMPANIED BY HYPONATREMIA: A CASE REPORT

Öz

Lithium is a mood stabilizer frequently used in bipolar disorder. Because of its narrow therapeutic range, even small fluctuations in serum levels may cause toxicity. As lithium is mainly excreted by the kidneys, disturbances in sodium or fluid balance significantly increase the risk of intoxication (1). This report presents a case of cardiac arrest secondary to lithium toxicity associated with hyponatremia.

Anahtar Kelimeler

• Lithium intoxication
• Hyponatremia
• Cardiac arrest
• Central pontine myelinolysis
• Cardiopulmonary resuscitation

HİPONATREMİNİN EŞLİK ETTİĞİ LİTYUM İNTOKSİKASYONUNA BAĞLI KARDİYAK ARREST: OLGU SUNUMU

Öz

Lityum, bipolar bozukluk tedavisinde sık kullanılan bir duygu durum düzenleyicisidir. Dar terapötik aralığı nedeniyle serum düzeyindeki küçük değişiklikler toksisiteye yol açabilir. Lityum atılımı büyük oranda böbreklerden gerçekleştiğinden, sodyum dengesindeki bozukluklar toksisite riskini artırır (1). Bu olgu, hiponatremi zemininde gelişen lityum intoksikasyonuna bağlı kardiyak arrest nedeniyle sunulmuştur.

Anahtar Kelimeler

• Lityum intoksikasyonu
• Hiponatremi
• Kardiyak arrest
• Santral pontin miyelinolizis
• Kardiyopulmoner resüsitasyon

Kaynakça

1. Gitlin M. Lithium side effects and toxicity: prevalence and management. Int J Bipolar Disord. 2016;4(1):27.
2. Waring WS. Clinical use and toxicity of lithium: pharmacokinetic and toxicokinetic perspectives. Toxicol Rev. 2006;25(4):221–230.
3. Grandjean EM, Aubry JM. Lithium: updated human knowledge using an evidence-based approach. Part III: Clinical safety. CNS Drugs. 2009;23(5):397–418.
4. Sterns RH. Disorders of plasma sodium—causes, consequences, and correction. N Engl J Med. 2015;372(1):55–65.
5. Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581–1589.
6. Mannheimer B, Falhammar H, Skov J, Rydén A, Melander O. Drug-induced hyponatremia in clinical care. Eur J Intern Med. 2025;115:106–118. doi:10.1016/j.ejim.2025.04.034.