KRONİK EOZİNOFİLİK PNÖMONİ TEDAVİSİNDE İNHALE KORTİKOSTEROİDLER

Abstract

Kronik eozinofılik pnömoni (KEP) kortikosteroidlere iyi cevap veren nadir görülen bir hastalıktır. Bununla birlikte kortikosteroid (KS) başlangıç dozları ve tedavi süresini belirleyen ortak görüş yoktur. En önemli komplikasyon ks dozu azaltılırken veya kesildiğinde gelişen nükslerdir. KEP ile birlikte astımı olduğu için inhale KS alan hastalarda nüks sıklığının daha az olduğu bildirilmekle birlikte KEP hastalarında inhale KS’lerin rolü belli değildir. Uzun süreli takipte relaps gelişen 7 KEP hastasına oral KS ile beraber inhale KS verilmesi planlandı. inhale KS tedavisi nüksleri ve obstrüktif solunum fonksiyon bozukluğunu artırmadan oral KS ihtiyacını azaltmıştır. Inhale ve oral KS’ler birlikte kullanılarak en düşük oral KS dozu kullanılabilir ve nükslerde uzun dönem izlem planlanmalıdır.

Keywords

• Kronik eozinofilik pnömoni
• tedavi
• inhale kortikosteroidler

INHALED CORTICOSTEROIDS IN THE TREATMENT OF CHRONIC EOSINOPHILIC PNEUMONIA

Abstract

Chronic eosinophilic pneumonia (CEP) is a rare disease which responds favourably to corticosteroid (CS) treatment. However, there is no consensus regarding the initial CS dose and duration of treatment. The major complication is the relapse of the disease upon tapering or discontinuation of CS treatment. The role of inhaled corticosteroids in CEP patients has not been evaluated, although a decreased frequency of relapse has been previously reported in CEP patients with asthma receiving inhaled corticosteroids. We decided to administer oral plus inhaled CS therapy in seven patients with CEP in whom relapse occurred during long-term follow-up. Inhaled CS treatment resulted in a reduced need for oral CS without causing an increase in relapse rate or obstructive lung function defect. By using inhaled and oral CS combination, the lowest dose of oral CS should be determined individually, and a long-term follow up should be planned in relapses.

Keywords

• Chronic eosinophilic pneumonia
• treatment
• inhaled corticosteroids

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