Akut Civa Zehirlenmesi İle Başvuran Çocuklarda Biyokimyasal Parametreler Ve Lipoprotein ilişkili Fosfolipaz A2 (Lp-Pla2) Düzeyleri

Year 2011, Volume: 5 Issue: 3, 100 - 103, 26.12.2011

Ömer Yılmaz

Abstract

Amaç: Çalışmada, akut civa toksisitesi saptanan çocuklarda biyokimyasal parametrelerin ve lipoprotein ilişkili fosfolipaz A2 düzeylerinin saptanması amaçlanmıştır.
Materyal ve Metod: Çalışmaya okul laboratuarında gerçekleşen bir kaza nedeniyle akut elemental civa maruziyeti oluşmuş 27 çocuk ve maruziyet hikayesi olmayan 24 sağlıklı kontrol dahil edilmiştir. ALT, AST, GGT, amilaz, üre, kreatinin, magnezyum, fosfor, kalsiyum düzeyi gibi biyokimyasal parametreler ve lipoprotein ilişkili fosfolipaz A2 seviyeleri saptanarak iki grup arasında fark olup olmadığı araştırılmıştır.

Bulgular: Yapılan istatistiksel analizlerde çalışılan parametreler açısından iki grup arasında farklılığa rastlanmamıştır.
Sonuç: Çalışılan parametrelerin civa zehirlenmesi olan çocuklarda akut dönemde etkilenmediği ve çalışma sonuçlarının örneklem zamanı ile ilişkili olduğu sonucuna varılmıştır.
Akut maruziyetin kronik dönemdeki etkilerinin monitörize edilmesi, farklı zamanlarda alınan örneklerde yapılacak ileri çalışmalarla aydınlığa kavuşabilecektir.

ABSRACT
Purpose: In our study, our aim is to detect the lipoprotein associated phospholipase A2 and biochemical parameters in children with acute mercury toxicity.
Material and Method: 27 children, who have been exposed to elemental mercury due to an accident in school laboratory and 24 healthy controls were included in the study. The difference between the two groups was investigated with analysis of biochemical parameters, including ALT, AST, GGT, amilase, urea, creatinine, magnesium, phosphorus, calcium and
lipoprotein associated phospholipase A2.

Findings: No difference between groups was demonstrated statistically.
Results: It has been concluded that; the analyzed parameters were not affected in acute period and results of analysis were related to the sampling time. Biomonitoring of chronic
effects of acute exposure needs further studies including periodical analysis of parameters in different sampling times

Keywords

Civa toksisitesi, lipoprotein ilişkili fosfolipaz A2, karaciğer enzimleri, böbrek fonksiyonu, kalsiyum

References

• 1. Houston MC. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. J Clin Hypertens 2011; 13(8): 621-7.
• 2. Hong YS, Kim YM, Lee KE. Methylmercury exposure and health effects. J Prev Med Public Health 2012; 45(6): 353-63.
• 3. Tezer H, et al. Household poisoning cases from mercury brought from school. Eur J Pediatr 2011; 170(3): 397-400.
• 4. Monteiro DA, Rantin FT, Kalinin AL. Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxa, Brycon amazonicus (Spix and Agassiz, 1829). Ecotoxicology 2010; 19: 105-23.
• 5. Virtanen JK, Rissanen TH, Voutilainen S, Tuomainen TP. Mercury as a risk factor for cardiovascular diseases. J Nutr Biochem 2007; 18: 75-85.
• 6. MacPhee CH, Moores KE, Boyd HF, Dhanak D, Ife RJ, Leach CA et al. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor. Biochem J 1999; 338 : 479-87.
• 7. Dennis E, Rhee S, Billah M, Hannun YS. Role of phospholipases in generating lipid second messengers in signal transduction. FASEB 1991; 5: 2068- 2077 .
• 8. Divecha N, Irvine R. Phospholipid signaling. Cell 1995; 80:269–278.
• 9. Balsinde J, Winstead MV, Dennis EA. Phospholipase A2regulation of arachidonic acid mobilization. FEBS Lett 2000; 531: 2–6
• 10. Mazerik JN, Hagele T, Sherwani S, Ciapala V, Butler S, Kuppusamy ML et al. Phospholipase A 2 activationregulates cytotoxicity of methylmercury in vascular endothelial cells. Int J Toxicol 2007; 26:553–569.
• 11. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid IntimaMedia Thickness Task Force. J Am Soc Echocardiogr 2008; 21:93–111.
• 12. Yaginuma-Sakurai K, Murata K, Shimada M, Nakai K, Kurokawa N, Kameo S, et al. Intervention study on cardiac autonomic nervous effects of methylmercury from seafood. Neurotoxicol Teratol 2009; 32:240–245.
• 13. Guallar E, Sanz-Gallardo MI, van’t Veer P, Bode P, Aro A, Gómez-Aracena J, et al. 2002. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 347:1747–1754.
• 14. Clarkson TW. Mercury. J Am Coll Toxicol 1989; 8(7):1291-1296.
• 15. Koyun M, Akman S, Güven AG. Mercury intoxication resulting from school barometers in three unrelated adolescents. Eur J Pediatr 2004; 163(3):131- 4.