Enteral Yolla Verilen Krizotil Asbestin Ratların Mide Mukozasına Etkileri

Year 2007, Volume: 1 Issue: 1, 13 - 18, 20.03.2007

Adnan Hasanoğlu

Abstract

Çevresel ve mesleksel asbest maruziyetinin akciğer ve plevrada maligniteye kadar varan patolojiler oluşturduğu bilinmektedir. Oral yolla alınan asbestin oluşturduğu patolojileri inceleyen çalışma sayısı çok azdır. Bu çalışma oral olarak alınan asbestin sindirim sisteminde oluşturduğu etkileri göstermek amacı ile planlanmıştır

Wistar albino cinsi 60 rat çalışmaya alınmış ve 3 gruba ayrılmıştır. Grup A(n:24) daki ratlara l,5gr/lt krizotil asbest ve su kanşımı; grup B(n:24) ye 3gr/lt krizotil asbest ve su karışımı kontrol grubu olan grup C(n:12) ye ise sadece su biberonla verildi. Her 3 ayda bir grup A ve B’den 6 şar, grup C’den 3 er rat eter anestezi ile sakrifıye edildi. Karaciğer, dalak, bağırsak, mezenter lenf nodları ve mide mukozasından örnekler alınarak histopatolojik inceleme yapıldı.
Grup B’deki ratlarda 3. aydan itibaren incisura angularis’de mi¬de displazisi tesbit edildi. Birinci yılın sonunda grup A ve B deki ratlarda kontrol grubuna göre önemli ve şiddetli displazi ve dalakta asbest cisimcikleri görülmüştür(p<0.005). Ayrıca dalakta subkapsüler fıbrozis oluşumu belirlenmiştir.
Sonuç olarak; ağız yoluyla ratlara verilen asbestin maligniteye yol açacak şekilde gastrik mukozada patolojik değişikliklere sebep olduğu gösterilmiştir. Ayrıca dalakta görülen asbest cisimcikleri ve patolojik değişiklikler retiküloendotelyal sistemin de sürece katıldığını düşündürmüştür.

Abstract
Occupational and environmental asbestos exposure by inhalation causes pulmonary diseases such as asbestosis, pulmonary and pleural malignancies, pleural fibrosis and calcifications.
This study is designed to show the effects of orally taken asbestos to the gastric mucosa. Sixty Wistar-albino rats were separated into 3 groups. Group A(n:24) had taken 1.5 gr/lt chrysotile asbestos with water. Group B(n:24) had taken 3 gr/lt asbestos with water and Group C(n:12) as a control group had taken only water. Asbestos water solution or only water was given to the rats with baby’s bottle. At every 3 months 6 rats from group A and B; 3 rats from group C were sacrificed. Samples from their gastric mucosa, intestine, liver, spleen and mesenterial lymph nodes were taken for histopathological examination. Gastric dysplasia on incisura angularis was shown in the rats of group B at the end of third month. At the end of one year on the rats in group A and B significant dysplasia was demonstrated in comparison with control group(p<0.005). Asbestos bodies were coexisted with subcapsular fibrosis in the spleen.
As a conclusion; it is shown that orally taken asbestos fibers made some changes on gastric mucosa that might lead to malignancies. Asbestos bodies which were seen in the spleen are the evidence of the involvement of reticuloendothelial system.

Keywords

Asbest, krizotil, mide karsinomu

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