Thyrotoxicosis and perinuclear antineutrophil cytoplasmic Antibody (p-anca) associated vasculitis: case report

Year 2007, Volume: 1 Issue: 3, 191 - 194, 20.11.2007

Reyhan Ersoy

Abstract

Leucocytoclastic vasculitis is the most common form of cutaneous vasculitic syndromes, it occupies the small vessels. It may appear as a primary form or secondary to drugs, autoimmune diseases and infections. Typical findings are skin lesions like palpable purpura and hemorrhagic vesicules. In this paper we reported two patients. One patient had Graves disease presented initially as vasculitic syndrome and the other one had vasculitic lesions under the propylthiouracil treatment. In both cases perinuclear antineutrophilic cytoplasmic antibody (p-ANCA) was detected. We described these rare forms of leucocytoclastic vasculitic syndromes based on thyrotoxicosis linked to different etiologies.

Keywords

Graves disease, antithyroid drugs, vasculitis, ANCA

Tirotoksikoz ve Perinükleer Antinötrofil Sitoplazmik Antikorla (p-ANCA) İlişkili Vaskülit: Olgu Sunumu

Abstract

Lökositoklastik vaskülit, küçük çaplı damarların tutulduğu bir tablo olup en sık görülen kutane vaskülit formudur. Primer bir hastalık olarak ortaya çıkabildiği gibi bazı ilaçlar, otoimmün hastalıklar ve enfeksiyonlar vaskülit gelişiminden sorumlu olabilir. Palpe edilebilen purpura ve hemorajik veziküllerden oluşan döküntü hastalığın en tipik görünümünü oluşturur.

Bu bildiride, biri Graves hastalığının ilk belirtisi olarak ortaya çıkan, diğeri propiltiyourasil (PTU) kullanımına bağlı gelişen ve perinükleer antinötrofil stoplazmik antikor (p-ANCA) pozitifliği saptanan iki lökositoklastik vaskülit olgusu, tablonun tirotoksikoz zemininde farklı etiyolojilerle gelişmesi ve nadir görülmesi nedeniyle sunulmuştur.

Keywords

Graves hastalığı, antitiroid ilaçlar, ANCA, vaskülit

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