Systemic Immunological Changes in Seborrheic Blepharitis

Year 2008, Volume: 2 Issue: 1, 227 - 230, 23.03.2008

Fatma Yulek

Abstract

The aim of the study is to evaluate the systemic immunological changes in seborrheic blepharitis. Twenty seven patients with seborrheic blepharitis and 24 patients without blepharitis were evaluated in terms of Schirmer and fluorescein break -up time (FBUT) scores, serum levels of CRP, Ig M and Ig E. The tear function tests of the groups were significantly different. Schirmer scores of the blepharitis group and of the control group were 15.75±5.20 mm and 18.15±3.02 mm respectively (p value: 0.006). FBUT score of the blepharitis group was 5.02+1.69 seconds and that of the control group was 9.90+2.25 seconds (p: 0.000). Serum levels of CRP was 4.73±2.36 mg/L in the blepharitis group and it was 3.13±1.32 mg/L in the control group. This was a statistically significant difference (p: 0.005). Ig M levels were higher in blepharitis group (1.31±0.62 g/L) than in the control group (0.95±0.27 g/L) This was statistically significant too (p:0.01). Serum levels of Ig E were not significantly different between the two groups. Seborrheic blepharitis may be associated with subclinical systemic immunologic problems. Detailed immunological tests may be helpful in the evaluation of this pathology.

Keywords

Blepharitis, CRP, Ig M, Ig E, inflammation

Seboreik Blefaritte İmmünolojik Tablo

Abstract

Çalışmamızda Seboreik blefaritli olgularda sistemik immünolojik enflamatuar değişikliklerin araştırılması planlandı. Seboreik blefariti olan 27 hasta ile blefarit şikayet ve bulguları olmayan 24 kontrol vakasının Schirmer testi değerleri, flöresein kırılma zamanı (FKZ), serum kantitatif C reaktif protein (CRP), Ig M ve Ig E düzeyleri değerlendirildi. Göz yaşı testlerinden Schirmer değerleri; blefarit grubunda ortalama 15.75±5.20 mm, kontrol grubunda 18.15+3.02 mm olarak ölçülmüştür. FKZ ise blefarit grubunda 5.02+1.69 saniye; kontrol grubunda 9.90±2.25 saniye olarak saptanmış olup iki grup arasından göz yaşı testleri açısından anlamlı bir fark saptanmıştır (Schirmer için p: 0.006, FKZ için p: 0.000). CRP düzeyleri; blefarit grubunda ortalama 4.73±2.36 mg/L ve kontrol grubunda 3.13±1.32 mg/L’dir ve aradaki fark istatistiksel olarak anlamlı bulunmuştur (p: 0.005). Ig M düzeyleri, blefarit grubunda 1.31+0.62 g/L, kontrol grubunda 9510.27 g/L olup, aradaki fark yine istatistiksel olarak anlamlı saptanmıştır (p: 0.01). Ig E düzeyleri açısından ise iki grup arasında anlamlı bir fark bulunmamıştır. Seboreik blefarit hastalarında sistemik enflamasyona bağlı olarak immünolojik tabloda değişiklikler görülebilir. Bu konuda daha fazla immünolojik göstergenin incelenmesi gerektiği kanaatindeyiz.

Keywords

lefarit, CRP, Ig M, Ig E, enflamasyon

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