Distance learning has undergone great changes, especially since the advent of the Internet and communication and information technology. Questions have been asked following the growth of this mode of instructional activity. Researchers have investigated methods to assess the benefits of e-learning from a number of perspectives. This survey assesses the associations among the system quality, information quality, and service quality on student satisfaction and use of systems in virtual learning environments using the e-learning success model adapted by Holsapple and Lee-Post from the Delone and McLean (1992, 2003) model as a theoretical basis. The survey was carried out by means of an online program offered to 291 students from public and private institutions from several regions of Brazil. Confirmatory Factor Analysis and Structural Equation Modeling were used for data analysis in order to understand the student satisfaction process in virtual learning system. Findings show that variations in system quality, information quality, and service quality influence the use of the system, and the User Satisfaction construct had 89% of variance explained by Information Quality and Service Quality. Many of the benefits of distance learning programs are related to students’ satisfaction and the intensity with which they make use of the learning system. With awareness of the indicators that are antecedents of these variables, education executives can plan investments that meet the most significant demands and use the information to deal with one of the major problems in distance learning: the dropout rate. Future researches should study this subject longitudinally.